A5072289691- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Infant Nutrition and Health
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Cardiovascular Conditions and Treatments
- Congenital Diaphragmatic Hernia Studies
- Mechanical Circulatory Support Devices
- Neonatal and Maternal Infections
- Child Nutrition and Feeding Issues
- Preterm Birth and Chorioamnionitis
- Breastfeeding Practices and Influences
- Respiratory Support and Mechanisms
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Health, Medicine and Society
- Respiratory viral infections research
- Infant Health and Development
- Assisted Reproductive Technology and Twin Pregnancy
- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Emergency and Acute Care Studies
Nantes Université
2016-2025
PhysioPathologie des Adaptations Nutritionnelles
2016-2025
Inserm
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Centre Hospitalier Universitaire de Nantes
2015-2024
Centre d'Investigation Clinique de Nantes
2015-2024
Hôpital Mère-Enfant
2006-2022
IMT Atlantique
2018-2021
Université Paris-Est Créteil
2021
Centre Val de Loire
2020
<h3>Importance</h3> Up-to-date estimates of the health outcomes preterm children are needed for assessing perinatal care, informing parents, making decisions about and providing evidence clinical guidelines. <h3>Objectives</h3> To determine survival neonatal morbidity infants born from 22 through 34 completed weeks’ gestation in France 2011 compare these with a comparable cohort 1997. <h3>Design, Setting, Participants</h3> The EPIPAGE-2 study is national, prospective, population-based...
We compared the frequency of behavioral problems in very preterm and term children at 5 years age. hypothesized that would be associated with cognitive impairment environmental factors differences between 2 groups reduced but persist after adjusting for performance factors.The Etude Epidémiologique sur les Petits Ages Gestationnels (EPIPAGE) study was a prospective population-based cohort included all births occurring 22 32 weeks' gestation control group infants born 39 to 40 1997 9 French...
Context Supplementation of breast milk is difficult once infants suckle the and often discontinued at end hospitalisation after discharge. Thus, breastfed preterm are exposed to an increased risk nutritional deficit with a possible consequence on neurodevelopmental outcome. Objective To assess relationship between feeding time discharge, weight gain during Design Observational cohort study. Setting Two large, independent population-based cohorts very infants: Loire Infant Follow-up Team...
Abstract Objectives To describe neurodevelopment at age 5 among children born preterm. Design Population based cohort study, EPIPAGE-2. Setting France, 2011. Participants 4441 aged 5½ 24-26, 27-31, and 32-34 weeks Main outcome measures Severe/moderate neurodevelopmental disabilities, defined as severe/moderate cerebral palsy (Gross Motor Function Classification System (GMFCS) ≥2), or unilateral bilateral blindness deafness, full scale intelligence quotient less than minus two standard...
A randomised double blind study was designed to evaluate haemodynamic response dobutamine and dopamine in 20 hypotensive preterm infants of less than 32 weeks' gestation. Neonates initially received or 5 micrograms/kg/min. If mean arterial pressure (MAP) remained below 31 mm Hg, the infusion rate increased increments micrograms/kg/min initial drug failed achieve a MAP above 30 it discontinued other administered at same rate. Left ventricular output (LVO) measured by pulsed Doppler...
To determine whether neonatal infections are associated with a higher risk of adverse neurodevelopment at 5 years age in population-based cohort very preterm children.We included all live births between 22 and 32 weeks gestation, from 9 regions France, 1997 (EPIPAGE study). Of the 2665 births, 2277 were eligible for follow-up evaluation age: 1769 had medical examination 1495 underwent cognitive assessment. Cerebral palsy impairment studied as function early-onset sepsis (EOS) late-onset...
Aim The aim of this study was to assess the independent role cerebral lesions on ultrasound scan, and several other neonatal obstetric factors, as potential predictors palsy (CP) in a large population‐based cohort very preterm infants. Method As part EPIPAGE, prospective study, perinatal data outcome at 5 years age were recorded for 1812 infants born before 33 weeks gestation nine regions France 1997. Results group comprised 942 males (52%) 870 females with mean gestational 30 (SD 2wks;...
OBJECTIVE: To determine whether mild and severe growth restriction at birth among preterm infants is associated with neonatal mortality cerebral palsy cognitive performance 5 years of age school 8 age. METHODS: All 2846 live births between 24 32 weeks' gestation from 9 regions in France 1997 were included a prospective observational study (the EPIPAGE [Étude Epidémiologique sur les Petits Ages Gestationnels] study) followed until Infants classified as “small-for-gestational-age” (SGA) if...
The aim of this study was to demonstrate a possible correlation between bone microarchitecture and primary implant stability.Twenty-two implants (Ankylos((R)) Straumann((R))) were inserted into the maxillae mandibles human cadavers. Bone structure determined by computed tomography in three specimens (male, age 53; female, 67; 80). A strict clinical protocol used for implantation. Primary stability measured resonance frequency analysis (Osstell Mentor). analyzed micro-computed (CT)....
In Brief OBJECTIVE: To evaluate the rates of in-hospital death, neonatal complications, and 5-year outcomes infants born at 30–34 weeks gestation. METHODS: nine regions France, all 2,020 stillbirths live births 30, 31, 32 in 1997 457 33 34 April October were recorded. Survivors evaluated 5 years age. RESULTS: Increasing gestational age from 30 to was associated with progressive decreases mortality (from 8.1% 0.4%) complications (respiratory distress syndrome, 43.8% 2.6%; maternofetal...
Objective To investigate the association of motor and cognitive/learning deficiencies overall disabilities in very preterm (VPT) children their relations to gestational age (GA) brain lesions. Design, Setting, Participants EPIPAGE is a longitudinal population-based cohort study born before 33 weeks' gestation (WG) 9 French regions 1997–1998. Cumulating data from all follow up stages, neurodevelopmental outcomes were available for 90% 2480 VPT survivors at 8 years. Main cognitive existence...
<h3>Importance</h3> There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants. Less pharmacological closure more supportive management have been observed without evidence to support these changes. <h3>Objective</h3> To evaluate association between early echocardiography PDA in-hospital mortality. <h3>Design, Setting, Participants</h3> Comparison screened not infants enrolled EPIPAGE 2 national prospective population-based...
Our goals were to (1) validate the parental Ages and Stages Questionnaires (ASQ) as a screening tool for psychomotor development among cohort of ex-premature infants reaching 2 years, (2) analyse influence socio-economic status maternal education on efficacy questionnaire. A regional population 703 very preterm (<35 weeks gestational age) born between 2003 2006 evaluated at years by their parents who completed ASQ, pediatric clinical examination, revised Brunet Lezine psychometric test with...
Objectives To evaluate the risk of very preterm birth (22–32 weeks gestation) associated with previous induced abortion according to complications leading delivery in singletons. Design Multicentre, case‐control study (the French EPIPAGE study). Setting Regionally defined population births France. Sample The sample consisted 1943 live‐born singletons (<33 gestation), 276 moderate (33–34 weeks) and 618 unmatched full‐term controls (39–40 weeks). Methods Data from were analysed using...
To describe the long-term outcome of very preterm infants receiving prolonged sedation and/or analgesia and examine relationship between this outcome.A prospective population-based study (Etude EPIdémiologique sur les Petits Ages GEstationnels [EPIPAGE]). reduce bias, propensity score method was used.Nine regions France.The population included fewer than 33 weeks' gestational age, born in 1997, who received mechanical ventilation surgery. Main Exposure Prolonged exposure to sedative...
Abstract Aim: To assess cerebral lesions and other medical as well social characteristics predictors of risk mild severe cognitive deficiencies in very preterm infants. Methods: As part the EPIPAGE population‐based prospective cohort study, perinatal data outcome at 5 years age were recorded for 1503 infants born before 33 weeks gestation nine regions France 1997. Mild deficiency was defined a Mental Processing Composite score on Kaufman Assessment Battery Children test between 70 84,...