A5062999636- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Birth, Development, and Health
- Pesticide Exposure and Toxicity
- Chemical Analysis and Environmental Impact
- Prenatal Substance Exposure Effects
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Urological Disorders and Treatments
- Climate Change and Health Impacts
- Pregnancy and Medication Impact
- Congenital Anomalies and Fetal Surgery
- Prenatal Screening and Diagnostics
- Maternal Mental Health During Pregnancy and Postpartum
- Per- and polyfluoroalkyl substances research
- Folate and B Vitamins Research
- Tracheal and airway disorders
- Gestational Diabetes Research and Management
- Neonatal and fetal brain pathology
- Breastfeeding Practices and Influences
- Environmental Justice and Health Disparities
École des Hautes Études en Santé Publique
2018-2025
Centre Hospitalier Universitaire de Rennes
2016-2025
Institut de Recherche en Santé, Environnement et Travail
2016-2025
Inserm
2016-2025
Université de Rennes
2016-2025
Triangle
2023
Indianapolis Zoo
2023
Committee on Publication Ethics
2023
University Medical Center Groningen
2023
University of Groningen
2023
<h3>Importance</h3> Up-to-date estimates of the health outcomes preterm children are needed for assessing perinatal care, informing parents, making decisions about and providing evidence clinical guidelines. <h3>Objectives</h3> To determine survival neonatal morbidity infants born from 22 through 34 completed weeks’ gestation in France 2011 compare these with a comparable cohort 1997. <h3>Design, Setting, Participants</h3> The EPIPAGE-2 study is national, prospective, population-based...
Background: Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies—and fewer epidemiologic investigations—have examined the potential effects prenatal exposure.Objectives: We assessed association between adverse birth outcomes and urinary biomarkers exposure, while taking into account exposures to other herbicides used on corn crops (simazine, alachlor, metolachlor, acetochlor).Methods: This study a case-cohort design nested prospective cohort...
Chlordecone (Kepone) is an organochlorine insecticide that has been used as and fungicide. In the French West Indies, Guadeloupe Martinique, it was intensively applied to banana fields from 1973 1993 control root borers. This pesticide undergoes no significant biotic or abiotic degradation in environment still present soils where applied. It only 1999 health environmental authorities became aware of extent chlordecone pollution media, including soils, waterways, food chain. Earlier...
<h3>Objective</h3> The potential impact of environmental exposure to pyrethroid insecticides on child neurodevelopment has only just started receive attention despite their widespread use. We investigated the associations between prenatal and childhood behavioural skills in 6-year-olds. <h3>Methods</h3> PELAGIE cohort enrolled 3421 pregnant women from Brittany, France 2002 2006. 428 mothers were randomly selected for study when children turned 6, 287 (67%) agreed participate. Children9s...
To assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AEDs) during first 2 months of pregnancy and risk 23 major congenital malformations (MCMs). This nationwide cohort study, based on French health care databases, included all pregnancies ≥20 weeks ending January 2011 March 2015. Women were considered be exposed when an AED had been dispensed 1 month before after beginning pregnancy. The reference group pregnant women no reimbursement for AEDs....
ABSTRACT Background In Europe, the prevalence of congenital ocular anomaly (COA) is estimated at 3.7 per 10,000 births. While certain COAs have a genetic origin, cause for most patients remains unknown. The role medications administered during pregnancy in COA genesis humans unclear. Objective To investigate any association between fetal exposure first trimester to and occurrence COA. Methods We conducted case‐malformed‐control study using data on 298,351 cases registered as having anomalies...
Objective: To study the relations between maternal occupational exposure to solvents during pregnancy and risk of congenital malformations. Methods: A prospective population-based cohort, specifically designed impact on malformations, began in 2002 three districts Brittany (France). 3421 pregnant women were recruited until end 2005 by physicians before 19 weeks gestation followed through birth. Information outcomes was obtained from hospital. Occupational at beginning assessed women’s...
Although prenatal exposure to water disinfection by-products does not appear affect the duration of gestation, its impact on fetal growth remains an open question. The authors studied associations between and restriction (FGR) preterm birth in PELAGIE cohort, a French cohort comprising 3,421 pregnant women recruited 2002 2006. Exposure was assessed by estimating levels trihalomethanes (THMs) tap during pregnancy maternal use measuring urinary trichloroacetic acid (TCAA) early nested...
Persistent organic pollutants have not been conclusively associated with length of gestation or preterm birth. Chlordecone is an organochlorine pesticide that has extensively used to control the banana root borer population in French West Indies. Data from Timoun Mother–Child Cohort Study conducted Guadeloupe between 2004 and 2007 were examine associations chlordecone concentrations maternal plasma rate birth 818 pregnant women. analyzed using multivariate linear regression for a Cox model...
Abstract Background Evidence on the direction and strength of association between maternal age prevalence congenital heart defects (CHD) in different group categories is conflicting. Some studies have illustrated trends with an increase younger older groups while other reported a linear relationship. Given over recent years, it important to study CHD by age. Objectives To examine Europe 1995 2015 using population‐based data from 24 registries belonging European Surveillance Congenital...
Recommendations about risks and benefits of seafood intake during pregnancy have been published in the last decade, but specific health effects different categories remain unknown. Fish shellfish may differ according to their fatty acid content concentration chemical pollutants toxins. Not taking these particularities into account result underestimating both positive negative on birth outcomes partly explains inconsistent results subject. In PELAGIE cohort study, including 2398 pregnant...
Abstract Background Recent studies suggest that a M editerranean dietary pattern during pregnancy may influence outcomes. The aim of this study was to evaluate the effect adherence diet ( MD ) on fetal growth restriction FGR and preterm delivery PTD in F rench C aribbean island where population is largely A frican descent presents patterns similar . Methods Using data from TIMOUN Mother–Child Cohort Study conducted G uadeloupe W est I ndies) between 2004 2007, we analysed for 728 pregnant...
Background:Several studies suggest that exposure to organophosphate insecticides (OP) during pregnancy impairs neurodevelopment in children.Objectives:We evaluated associations between biomarkers of prenatal and postnatal OP cognitive function 6-year-olds a French longitudinal birth cohort.Methods:In 2002–2006, the PELAGIE mother–child cohort enrolled pregnant women from Brittany. For random subcohort, we measured nonspecific dialkylphosphate metabolites (DAP) one maternal urine sample,...
Abstract Background An association between education and preterm delivery has been observed in populations across E urope, but differences methodology limit comparability. We performed a direct cross‐cohort comparison of educational disparities based on individual‐level birth cohort data. Methods The study included data from 12 uropean cohorts D enmark, ngland, F rance, L ithuania, the N etherlands, orway, I taly, P ortugal, S pain. 2434 99 655 pregnancies. maternal (22–36 completed weeks...
Abstract Achondroplasia is a rare genetic disorder resulting in short‐limb skeletal dysplasia. We present the largest European population‐based epidemiological study to date using data provided by Surveillance of Congenital Anomalies (EUROCAT) network. All cases achondroplasia notified 28 EUROCAT registries (1991–2015) were included study. Prevalence, birth outcomes, prenatal diagnosis, associated anomalies, and impact paternal maternal age on de novo presented. The population consisted 434...
Objective: Thirty years ago it was demonstrated that folic acid taken before pregnancy and in early reduced the risk of a neural tube defect (NTD). Despite Public Health Initiatives across Europe recommending women take 0.4 mg becoming pregnant during first trimester, prevalence NTD pregnancies has not materially decreased EU since 1998, contrast to dramatic fall observed USA. This study aimed estimate number would have been prevented if flour had fortified with from 1998 as Design Setting:...
Abstract Purpose Antiretroviral drugs are recommended during pregnancy to achieve HIV viral suppression and reduce mother-to-child transmission. Congenital anomaly signals were reported after fetal exposure antiretroviral in several studies warranting further investigation. We aimed evaluate the risk of congenital anomalies using European registry data. Methods A case/non-case study was performed, EUROmediCAT central database. All anomalies, exposed any drugs, included from 1995 2019....
Pesticide use is widespread in agriculture. Several studies have shown that pesticides used agricultural fields can contaminate the domestic environment and thus be an important source of pesticide exposure populations residing nearby. Epidemiological examined health effects utero from residence near activities suggest adverse effects, but results are inconsistent. Our purpose was to investigate effect on intrauterine growth such due residential municipality. A prospective birth cohort...