A5026644495- Cannabis and Cannabinoid Research
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Forensic Toxicology and Drug Analysis
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Electrolyte and hormonal disorders
- Esophageal Cancer Research and Treatment
- Metabolomics and Mass Spectrometry Studies
- Thyroid Cancer Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
University of Copenhagen
2013-2024
Rigshospitalet
1990-2014
Copenhagen University Hospital
1990-2013
Capital Region of Denmark
2013
Friedrich-Ebert-Krankenhaus
2008-2012
Bispebjerg Hospital
2010
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
1995-2009
Aarhus University Hospital
2009
Odense University Hospital
1989-2009
Aalborg University Hospital
2009
Dietary fat is thought to stimulate release of incretin hormones via activation fatty acid receptors in the intestine. However, dietary (triacylglycerol) digested 2-monoacylglycerol and acids. Activation G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) from intestinal L-cells. We aimed investigate if 2-oleoyl glycerol (2OG) can activate GPR119 vitro GLP-1 secretion vivo.Agonist activity for various lipids was tested on transiently expressed human COS-7...
Endogenous cannabinoid receptor ligands (endocannabinoids) may rescue neurons from glutamate excitotoxicity. As these substances also accumulate in cultured immature following neuronal damage, elevated endocannabinoid concentrations be interpreted as a putative neuroprotective response. However, it is not known how glutamatergic insults affect vivo homeostasis, i.e. N ‐arachidonoylethanolamine (anandamide) and 2‐arachidonoylglycerol (2‐AG), well other constituents of their lipid families,...
A joint Danish-Finnish-Swedish case-referent investigation was initiated in 1977 order to study the connection between nasal and sinonasal cancer various occupational exposures. All new cases of were collected from national registers (Finland Sweden) or hospitals (Denmark). Those still alive who agreed an interview (N = 167) individually matched for age sex with patients colonic rectal cancer. detailed telephone made according standardized forms. Both referents thought that their condition...
The availability of useful animal models reflecting the human obesity syndrome is crucial in search for novel compounds pharmacological treatment obesity. In current study, we have performed an extensive characterization a polygenetic model, namely selectively bred diet-induced obese (DIO) and diet-resistant (DR) rat strains. We show that they constitute syndrome. DIO DR rats were fed either high-energy (HE) or standard chow (Chow) diet from weaning to 9 months age. Metabolic including blood...
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, relative importance FFA1 (G Protein-coupled Receptor [GPR] 40), FFA4 (GPR120), and GPR119, which all recognize TG metabolites, ie, long-chain fatty acid 2-monoacylglycerol, respectively, is still unclear. Here, we find 3 receptors to be highly expressed enriched in fluorescence-activated cell sorting-purified GLP-1 GIP cells isolated from transgenic reporter mice. In vivo, TG-induced increase...
This study was undertaken to investigate the link between dietary fat content and intestinal levels of anorectic AŁacylethanolamines (NAEs), including oleoyleth-anolamide (OEA), palmitoylethanolamide (PEA), lino-leoylethanolamide (LEA). Male rats were fed high-fat diets (HFDs) with variable percentages [20–45% total energy (E%)] for 1–7 d;afterward, jejunums isolated, jejunal NAE measured by liquid-chromatography mass spectrometry. Enzyme activities mRNA expression two synthesizing enzymes,...
Abstract Focal cerebral ischaemia has an initial phase of inflammation and tissue injury followed by a later resolution repair. Mass spectrometry imaging (desorption electrospray ionization matrix assisted laser desorption ionization) was applied on brain sections from mice 2 h, 24 5d, 7d, 20d after permanent focal ischaemia. Within N -acyl-phosphatidylethanolamines, lysophosphatidylcholine, ceramide accumulated, while sphingomyelin disappeared. At the stages, bis(monoacylglycero)phosphate...