A5074597440- Cannabis and Cannabinoid Research
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Diabetes Treatment and Management
- Ginger and Zingiberaceae research
- Connexins and lens biology
- Eating Disorders and Behaviors
- Alcohol Consumption and Health Effects
- Neuroscience of respiration and sleep
- Diet and metabolism studies
- Heme Oxygenase-1 and Carbon Monoxide
- Sirtuins and Resveratrol in Medicine
- Neuropeptides and Animal Physiology
- Pharmacology and Obesity Treatment
- Cardiovascular Disease and Adiposity
University of Copenhagen
2009-2021
Novo Nordisk Foundation
2017-2021
Rigshospitalet
2011
Dietary fat is thought to stimulate release of incretin hormones via activation fatty acid receptors in the intestine. However, dietary (triacylglycerol) digested 2-monoacylglycerol and acids. Activation G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) from intestinal L-cells. We aimed investigate if 2-oleoyl glycerol (2OG) can activate GPR119 vitro GLP-1 secretion vivo.Agonist activity for various lipids was tested on transiently expressed human COS-7...
This study was undertaken to investigate the link between dietary fat content and intestinal levels of anorectic AŁacylethanolamines (NAEs), including oleoyleth-anolamide (OEA), palmitoylethanolamide (PEA), lino-leoylethanolamide (LEA). Male rats were fed high-fat diets (HFDs) with variable percentages [20–45% total energy (E%)] for 1–7 d;afterward, jejunums isolated, jejunal NAE measured by liquid-chromatography mass spectrometry. Enzyme activities mRNA expression two synthesizing enzymes,...
Significance Obesity is a major health threat of the twenty-first century, impacting individual patients and healthcare expenditure. Due to safety concerns, few antiobesity treatments with only moderate effect remain on market. The ghrelin receptor an attractive target for development novel drugs, since increases both fat accumulation food intake. However, also modulates variety additional physiological functions. Thus, drugs targeting may induce unacceptable side effects have limited...
Neurons in the arcuate nucleus of hypothalamus are involved regulation food intake and energy expenditure, dysregulation signalling these neurons promotes development obesity. The role rate-limiting enzyme NAD+ salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT), for homeostasis by has not been extensively studied.We determined whether Nampt mRNA or protein levels mice were affected diet-induced obesity, fasting re-feeding, leptin ghrelin treatment. Primary hypothalamic treated...
Obesity is a complex disease associated with high risk of comorbidities. Gastric bypass surgery, an invasive procedure low patient eligibility, currently the most effective intervention that achieves sustained weight loss. This beneficial effect attributed to alterations in gut hormone signaling. An attractive alternative pharmacologically mimic effects bariatric surgery by targeting several hormonal axes. The G protein-coupled receptor 39 (GPR39) expressed gastrointestinal tract has been...
Oleoylethanolamide and several other N-acylethanolamines (NAEs), e.g. linoleoylethanolamide palmitoylethanolamide, have anorectic properties in rats, prolonged intake of a high-fat diet decreases the levels NAEs jejunum. Jejunal are thought to add control food via activation PPARalpha vagus nerve. The fat-induced decrease may explain part hyperphagic effect diets. In present study, we investigated 1) whether reduced were reversible 2) mice respond dietary fat (olive oil) by reducing NAEs, 3)...