A5020642212- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Thermal Regulation in Medicine
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Venous Thromboembolism Diagnosis and Management
- Trauma Management and Diagnosis
- Central Venous Catheters and Hemodialysis
- Pneumonia and Respiratory Infections
- Climate Change and Health Impacts
- Renal Transplantation Outcomes and Treatments
- Complement system in diseases
- Ultrasound in Clinical Applications
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Antimicrobial Resistance in Staphylococcus
Institut Gustave Roussy
2023-2025
Hôpital Saint-Antoine
2015-2024
Sorbonne Université
2015-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Hôpital Saint-Louis
2014-2024
Inserm
2010-2023
Sorbonne Paris Cité
2022-2023
Centre Hospitalier Intercommunal de Poissy
2020
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2019
Centre de Recherche Saint-Antoine
2019
<h3>Importance</h3> High-flow nasal oxygen therapy is increasingly used for acute hypoxemic respiratory failure (AHRF). <h3>Objective</h3> To determine whether high-flow decreases mortality among immunocompromised patients with AHRF compared standard therapy. <h3>Design, Setting, and Participants</h3> The HIGH randomized clinical trial enrolled 776 adult (Pao<sub>2</sub><60 mm Hg or Spo<sub>2</sub><90% on room air, tachypnea >30/min labored breathing distress, need ≥6 L/min) at 32...
<h3>Importance</h3> Keeping a diary for patients while they are in the intensive care unit (ICU) might reduce their posttraumatic stress disorder (PTSD) symptoms. <h3>Objectives</h3> To assess effect of an ICU on psychological consequences hospitalization. <h3>Design, Setting, and Participants</h3> Assessor-blinded, multicenter, randomized clinical trial 35 French ICUs from October 2015 to January 2017, with follow-up until July 2017. Among 2631 approached patients, 709 adult (with 1 family...
Chronic kidney disease (CKD) is a growing public health problem and end stage renal (ESRD) represents large human economic burden. It important to identify patients at high risk of ESRD. In order determine whether Doppler resistive index (RI) may discriminate those patients, we analyzed RI was associated with identified prognosis factors CKD, in particular histological findings, outcome.RI measured the 48 hours before biopsy 58 CKD patients. Clinical biological data were collected...
Abstract Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase (NOS) inhibitor, is accumulated in plasma during chronic kidney disease (CKD). It considered independent mortality and cardiovascular risk factor CKD patients. To test the involvement of ADMA progression, we investigated effects administration on renal structure compared these with $N^{\rm{G}}$ ‐nitro‐ L ‐arginine methyl ester (L‐NAME) treatment, a widely used exogenous inhibitor NOS that induces CKD. Three...
Thyroid storm represents a rare but life-threatening endocrine emergency. Only data are available on its management and the outcome of most severe forms requiring ICU admission. We aimed to describe clinical manifestations, in-ICU 6-month survival rates patients with those thyroid admission.Retrospective, multicenter, national study over an 18-year period (2000-2017).Thirty-one French ICUs.The local medical records from each participating were screened using International Classification...
Mottling score has been reported to be a strong predictive factor during septic shock. However, the pathophysiology of mottling remains unclear.In patients admitted in ICU for shock, we measured on same area mean skin perfusion by laser Doppler, score, and variations both indices between T1 (6 hours after vasopressors were started) T2 (24 later).Fourteen included, SAPS II was 56 [37-71] SOFA at 10 [7-12]. The surface analyzed 4108 ± 740 mm2; 1184 141 measurements performed over each defined...
Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate clinical features, management, and outcomes critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). This an observational study VZV-CAP admitted 29 intensive care units (ICUs) from January 1996 2015. One hundred two were included. Patients young (age 39 years (interquartile range 32–51)) 53 (52%) immunocompromised....
Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and other parameters remains unknown.
Microcirculatory disorders leading to tissue hypoperfusion play a central role in the pathophysiology of organ failure severe sepsis and septic shock. As microcirculatory have been identified as strong predictive factors unfavourable outcome, there is need develop accurate parameters at bedside evaluate perfusion. We evaluated whether different body temperature gradients could relate severity predict outcome critically ill patients with shock.We conducted prospective observational study...
Vitamin C has potential protective effects through antioxidant and anti-inflammatory properties. However, the effect of vitamin supplementation on microvascular function peripheral tissue perfusion in human sepsis remains unknown. We aimed to determine endothelial dysfunction septic shock patients.Patients with were prospectively included after initial resuscitation. Bedside skin reactivity response acetylcholine iontophoresis forearm area measured before 1 h intravenous (40 mg/kg)....
Given the high risk of thrombosis and anticoagulation-related bleeding in patients with hypoxemic COVID-19 pneumonia, identifying lowest effective dose anticoagulation therapy for these is imperative.To determine whether therapeutic (TA) or high-dose prophylactic (HD-PA) decreases mortality and/or disease duration compared standard-dose (SD-PA), TA outperforms HD-PA; to compare net clinical outcomes among 3 strategies.The ANTICOVID randomized open-label trial included pneumonia requiring...
Abstract Background Delayed intubation is associated with high mortality. There a lack of objective criteria to decide the time intubation. We assessed recently described combined oxygenation index (ROX index) predict in immunocompromised patients. The study secondary analysis randomized trials patients, including all patients who received high-flow nasal cannula (HFNC). first was evaluate accuracy ROX for acute respiratory failure. Results In study, 302 HFNC. Acute failure mostly related...
Severe hypothyroidism (SH) is a rare but life-threatening endocrine emergency. Only few data are available on its management and outcomes of the most severe forms requiring ICU admission. We aimed to describe clinical manifestations, management, in-ICU 6-month survival rates these patients. conducted retrospective, multicenter study over 18 years in 32 French ICUs. The local medical records patients from each participating were screened using International Classification Disease 10th...
Abstract Background Intensive care units (ICU) are characterized by high medical assistance costs and great complexity. Recommendations to determine the needs of staff scarce, generating appreciable variability. The French Care Society (FICS) National Council Medicine (CNP MIR, Conseil Professionel de Médecine Réanimation) have established a technical committee experts, purposes which were draft recommendations regarding staffing in ICUs propose optimal organisation work hours, key objective...
Among the numerous renal diseases observed in human immunodeficiency virus (HIV) patients, HIV-associated nephropathy (HIVAN) is a major cause of end-stage disease (ESRD). The purpose our study was to describe presentation and outcome HIVAN era highly active antiretroviral therapy (HAART).We analysed clinical features 57 patients with histologically proven diagnosed between 2000 2009 four teaching hospitals Paris, France.This series characterized by median age 41 years (18-58), frequent...
Background. Characteristics and outcomes of adult patients with disseminated toxoplasmosis admitted to the intensive care unit (ICU) have rarely been described. Methods. We performed a retrospective study on consecutive who were from January 2002 through December 2012 ICUs 14 university-affiliated hospitals in France. Disseminated was defined as microbiological or histological evidence disease affecting >1 organ immunosuppressed patients. Isolated cases cerebral excluded. Clinical data...