A5019071319- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Complement system in diseases
- Potassium and Related Disorders
- Neurological and metabolic disorders
- Health, Medicine and Society
- Erythropoietin and Anemia Treatment
- Muscle and Compartmental Disorders
- Healthcare Systems and Practices
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pharmacological Effects and Toxicity Studies
- Renal and Vascular Pathologies
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pharmaceutical Economics and Policy
- COVID-19 Clinical Research Studies
- Physical Activity and Health
Hôpitaux Universitaires de Strasbourg
2013-2024
Université de Strasbourg
2009-2024
Assistance Publique – Hôpitaux de Paris
2020
Agence de la Biomédecine
2020
Hôpital d'Hautepierre
2017
Hôpital Civil, Strasbourg
2013-2016
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy. However, value of anti-PLA2R1 antibody titers predicting patient outcomes unknown. Here, we screened serum samples from 50 patients positive for PLA2R1 immunoreactivity against a series deletion mutants covering extracellular domains. We identified reactive epitopes cysteine-rich (CysR), C-type lectin domain 1 (CTLD1), and 7 (CTLD7) domains confirmed reactivity with soluble forms each...
Acute renal failure (ARF) in critically ill patients is currently very frequent and requires replacement therapy (RRT) many patients. During the last 15 years, several studies have considered important issues regarding use of RRT ARF, like time to initiate therapy, dialysis dose, types catheter, choice technique, anticoagulation. However, despite an abundant literature, conflicting results do not provide evidence on implementation. We present herein recommendations for adult pediatric...
Rhabdomyolysis is a life-threatening disease that can lead to severe hyperkalemia, acute kidney injury (AKI) and hypovolemic shock. The predictive factors of AKI chronic (CKD) transition remain poorly described.This multicenter retrospective study enrolled 387 patients with rhabdomyolysis (CPK > 5000 U/L). Primary end-point was the development AKI, defined as stage 2 or 3 KDIGO classification. Secondary end-points included incidence CKD transition.Among patients, 315 (81.4%) developed...
The true cause of death in severe hyponatraemic patients remains controversial. present study aimed to analyse the relationship between comorbidity, medical management and prognosis patients. Medical records all hospitalised our institution 2012 with a plasma sodium ≤120 mmol/l were retrospectively analysed. One hundred forty-seven 64 723 adult (0.2 %) identified hyponatraemia. In-hospital mortality rate was 24.5 50.3 % after median follow-up 431 days. Patients <110 had less comorbidity...
Previous studies comparing the outcomes in haemodialysis (HD) with those peritoneal dialysis (PD) have yielded conflicting results.The aim of study was to compare survival planned HD versus PD patients a cohort adult incident who started renal replacement therapy (RRT) between 2006 and 2008 nationwide REIN registry (Réseau Epidémiologie et Information en Néphrologie). Patients RRT emergency or stopped within 2 months were excluded. Adjusted Cox models, propensity score matching marginal...
To the Editor, Recent randomized trials [1 , 2 ] have demonstrated renal and cardiovascular benefit of sodium-glucose cotransporter inhibitors ( SGLT2i) in chronic kidney disease CKD) patients, irrespective diabetes status.However, real-world data on their use advanced CKD stages remain scarce.This study aims to assess safety discontinuation reasons SGLT2i this demographic.We conducted a retrospective analysis 271 patients with stage 4 non-dialysed 5 CKD, from January 2020 December 2022,...
The prevalence of HTLV antibody was similar to that reported for HIV in the same population at time. 4With appropriate counselling, screening should be accepted light as testing HIV, which has recently been recommended part routine antenatal programme. 5However, unlike infection, infection with is less likely become clinically apparent, and factors conferring a high risk developing associated disease have not defined.In meantime, could help limit vertical transmission.We thank Dr Jennifer...
Renal angiomyolipomas (AMLs) are frequent in tuberous sclerosis and responsible for a significant proportion of the morbidity adulthood, mainly from bleeding complications, which correlated to size AMLs. We describe case 19-year-old female with multiple bilateral renal angiomyolipomas.The AMLs measured up 6 cm size. She was first treated low dose mammalian target rapamycin (mTOR) inhibitor sirolimus (up 3 mg/day over 12-month period) following AML reduction, percutaneous cryoablation...
Abstract Background The effect of dialysis dose on mortality remains unsettled. Current guidelines recommend targeting a single-pool Kt/V (spKt/V) at 1.20–1.40 per thrice-weekly session. However, the optimal mostly disputed. Methods In nationwide registry all incident patients receiving haemodialysis, 32 283 had available data dose, estimated by and its variants epuration volume session (Kt) Kt indexed to body surface area (Kt/A). Survival was analysed with multivariate Cox model concurrent...
Apheresis allows the fast removal of autoantibodies in anti-glomerular basement membrane (anti-GBM) disease, and severe antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. The CINEVAS study tested whether immunoadsorption (IA) allowed a faster ANCA and/or anti-GBM than plasma exchanges (PEx).
<b><i>Background/Aims:</i></b> The association of raised levels natriuretic peptides with elevated risk mortality was investigated in the present analysis Membrane Permeability Outcome study. <b><i>Methods:</i></b> N-terminal probrain type peptide (NT-proBNP) measured 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics patients NT-proBNP below above median were descriptively analysed and survival...
Hemodialysis patients with contraindication to systemic anticoagulation require a heparin-free hemodialysis technique. Among several alternatives heparin, predilution hemodiafiltration (HDF) is often used, albeit without any confirmation of its effectiveness.Patients hospitalized in nephrology ICU and hemodialysed for stage 5 CKD or AKI were randomized either standard HD polysulfone membrane, HDF the same membrane. Coagulation activation was evaluated clinically by need premature termination...
Abstract Background In the general population, metabolic syndrome (MetS) is predictive of major adverse cardiovascular events (MACE). Waist circumference (WC), a component MetS criteria, linked to visceral obesity, which in turn associated with MACE. However, haemodialysis (HD) patients, association between MetS, WC and MACE unclear. Methods cross-sectional study 1000 HD we evaluated prevalence characterised clinical predictors MetS. The relationship its components, alone or combination,...
Abstract Background Heparin‐induced thrombocytopenia (HIT) is a severe complication of heparin therapy associated with thrombosis that requires quick diagnosis. Therefore, laboratory assays must provide an accurate and swift answer. This work aims to evaluate the performances ELISA assay, especially when combined 4T risk score, functional assay. Methods Data were collected for 894 patients treated by who underwent anticoagulant switch because HIT suspicion examined multidisciplinary expert...
Abstract Background All chronic kidney diseases in diabetic patients are not diseases. The objective was to compare the clinical characteristics, survival and access transplantation starting dialysis classified either as disease (DKD) or non‐diabetic (NDKD). Methods We used nationwide French REIN registry analyse baseline characteristics at inception outcomes defined transplantation, deaths their causes. probability of death analysed using a multivariate Cox model Fine Gray competing for...