A5016778124- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Blood Pressure and Hypertension Studies
- Erythropoietin and Anemia Treatment
- Muscle and Compartmental Disorders
- Heart Failure Treatment and Management
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Advanced Glycation End Products research
- Potassium and Related Disorders
- Hemodynamic Monitoring and Therapy
- Parathyroid Disorders and Treatments
- Blood donation and transfusion practices
- Quality and Safety in Healthcare
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Allergic Rhinitis and Sensitization
- Sodium Intake and Health
- Food Allergy and Anaphylaxis Research
- Pharmacological Effects and Toxicity Studies
- Bone and Joint Diseases
- Renal and Vascular Pathologies
Fresenius Medical Care (Germany)
2011-2023
Assa Abloy (New Zealand)
2019-2020
Nierstichting
2019-2020
Institut National de la Recherche Agronomique
2014-2019
Bouygues (France)
2014
Fresenius Medical Care North America (United States)
2007
Background Euvolemia is an important adequacy parameter in peritoneal dialysis (PD) patients. However, accurate tools to evaluate volume status clinical practice and data on PD patients as compared healthy population, the associated factors, have not been available so far. Methods We used a bio-impedance spectroscopy device, Body Composition Monitor (BCM) assess cross-sectional cohort of prevalent different European countries. The results were age gender matched population. Results Only 40%...
<i>Background:</i> Controlled randomised studies to prove improved cardiovascular stability and anaemia management during on-line haemodiafiltration (oHDF) are scarce. <i>Methods:</i> 70 patients were treated with both haemodialysis (HD) oHDF in a cross-over design 2 × 24 weeks at dialysis dose of eKt/V≧1.2. Patients into group A started on HD switched over oHDF, whereas B began afterwards. Intradialytic morbid events (IME), such as symptomatic hypotension or muscle...
Non-euvolaemia in peritoneal dialysis (PD) patients is associated with elevated mortality risk. There an urgent need to collect data help us understand the association between clinical practices and hydration nutritional status, their effects on patient outcome.The aim of this prospective international, longitudinal observational cohort study follow up as measured by bioimpedance spectroscopy using body composition monitor (BCM) incident PD for 5 years. Measures status clinical, biochemical...
Volume overload is frequent in prevalent patients on kidney replacement therapies and associated with outcome. This study was devised to follow-up volume status of an incident population peritoneal dialysis (PD) relate this patient-relevant outcomes.This prospective cohort implemented 135 centers from 28 countries. Incident participants PD were enrolled just before the actual treatment started. measured using bioimpedance spectroscopy start thereafter 3-month intervals, together clinical...
In standard care, hemodialysis patients are often treated with a center-specific fixed dialysate sodium concentration, potentially resulting in diffusive changes for plasma concentrations below or above this level. While load may be associated thirst and higher interdialytic weight gain, excessive removal cause intradialytic symptoms. contrast, the new machine option "Na control" provides automated individualization of during treatment aim to reduce such without need determine concentration....
Peritoneal dialysis (PD) solutions with reduced sodium content may have advantages for hypertensive patients; however, they lower osmolarity and solvent drag, so the achieved Kt/Vurea be lower. Furthermore, increased transperitoneal membrane gradient can influence balance consequences blood pressure (BP) control.Prospective, randomized, double-blind clinical trial to prove noninferiority of total weekly low-sodium versus standard-sodium PD solution, confidence limit above clinically accepted...
<b><i>Background:</i></b> The majority of studies suggesting that online hemodiafiltration reduces the risk mortality compared to hemodialysis (HD) have been performed in dialysis-prevalent populations. In this report, we conducted an epidemiologic study incident dialysis patients, comparing post-dilution and high-flux HD, with propensity score matching (PSM) used correct indication bias. <b><i>Methods:</i></b> Our cohort comprised 3,075...
IntroductionAlthough high serum uric acid (SUA) has been consistently associated with an increased risk of death in the general population and persons nondialysis chronic kidney disease (CKD), studies patients undergoing dialysis are conflicting. It postulated that low SUA simply reflects poor nutritional status patients. We here characterize association between a large cohort explore effect modification by underlying as reflected body composition.MethodsIn this retrospective study, we...
Introduction: Long-term inappropriate proton pump inhibitors use (PPIs) is a matter of concern because the risks associated with their long-term in older patients chronic conditions.The risk PPI treatment hemodialysis remains unexplored. Methods:We assessed relationship between PPIs and death throughout retrospective multicenter propensity score-matched study.Information about demographic, treatment, laboratory data, concomitant medication was obtained from EuCliD database (Fresenius Medical...
Background Cardiovascular disease (CVD) related mortality and morbidity are high in end-stage renal (ESRD). The pathophysiology of CVD ESRD may involve non-traditional risk factors, such as accumulation advanced glycation endproducts (AGEs), dicarbonyls, endothelial dysfunction (ED) low-grade inflammation (LGI). However, detailed data on the relation AGEs dicarbonyls with ED LGI limited. Methods We examined cross-sectional Spearman’s rank correlations serum biomarkers 43 individuals chronic...
Abstract Immunoadsorption is well known to selectively remove immunoglobulins and immune complexes from plasma applied in a variety of autoimmune diseases for desensitization before, or at acute rejection after organ transplantation. Performance, safety, clinical effectiveness immunoadsorption were the aim this study. This prospective, noninterventional, multicentre cohort study included patients treated with (Immunosorba GLOBAFFIN adsorbers) any indication. Clinical was assessed termination...
Introduction The concentration of dialysate calcium (dCa) has been suggested to affect vascular calcification, but evidence is scarce. Calcification propensity reflects the intrinsic capacity serum prevent and phosphate precipitate. use citric-acid may have a beneficial effect on calcification due chelating magnesium. aim this study was compare intradialytic short-term effects haemodialysis with either standard acetic-acid dCa1.50 (A1.5) or dCa1.25 (A1.25), as well (C1.5) in bicarbonate...
Technique failure in peritoneal dialysis (PD) can be due to patient- and procedure-related factors. With this analysis, we investigated the association of volume overload at start during early phase PD technique failure.In observational, international cohort study with longitudinal follow-up incident patients, was defined as either transfer haemodialysis or death, transplantation considered a competing risk. We explored parameters baseline within first 6 months between 18 months, using risk...
Plasma sodium shifts during hemodialysis treatments can be minimized by application of a control algorithm. The present randomized cross-over trial was designed to apply this option on large patient cohort and observe the time course plasma over treatment. In one study phase, patients received post-dilution online hemodiafiltration with entire other isolated ultrafiltration first 90 min followed for remainder session, purpose follow possible initial equilibration process without influence...
Cardiovascular mortality is still high and many risk factors are inadequately controlled in patients on conventional chronic hemodialysis. Recent studies intensified treatment schedules by either increasing length or frequency of dialysis sessions have shown promising results with better control blood pressure, reduction left ventricular hypertrophy easier calcium/phosphate metabolism.The present observational study compared the effect different forms "intensified treatment" i.e. long...
Prevention of IgE-binding to cellular IgE-receptors by anti-IgE (Omalizumab) is clinically effective in allergic asthma, but limited IgE threshold-levels. To overcome this limitation, we developed a single-use immunoadsorber column (IgEnio). IgEnio based on recombinant, IgE-specific antibody fragment and can be used for the specific extracorporeal desorption IgE.To study safety efficacy regarding selective depletion randomized, open-label, controlled pilot trial patients with asthma...
High-flux dialyzers effectively remove uremic toxins, are hemocompatible to minimize intradialytic humoral and cellular stimulation, have long-term effects on patient outcomes. A new dialyzer with a modified membrane surface has been tested for performance hemocompatibility.This multicenter, prospective, randomized, crossover study involved the application of polysulfone-based FX CorAL 600 (Fresenius Medical Care, Bad Homburg, Germany), polyarylethersulfone-based Polyflux 170H (Baxter...
Purpose The appropriate use of vascular access is fundamental importance in the treatment hemodialysis (HD) patients. This survey entailed collecting data on current practice cannulation to assess its relation dialysis dose. Methods international, multicenter, observational, cross-sectional was performed 171 centers European network Fresenius Medical Care Europe and South Africa during April 2009. Practice patterns cannulations were documented by means a 24-item questionnaire. Dialysis dose...
Background Anemia is a major comorbidity of patients with end-stage renal disease and poses an enormous economic burden to health-care systems. High dose erythropoiesis-stimulating agents (ESAs) have been associated unfavorable clinical outcomes. We explored whether mixed-dilution hemodiafiltration (Mixed-HDF), based on its innovative substitution modality, may improve anemia outcomes compared the traditional post-dilution (Post-HDF). Methods included 174 adult prevalent dialysis (87...
Background Intradialytic morbid events (IMEs, mostly hypotension) are frequent complications during hemodialysis (HD). This study investigated whether automatic feedback control via adjustment of the ultrafiltration rate reduces IME frequency. Methods In this multi-center cross-over study, 56 hypotension-prone patients were treated both with standard HD (sHD, applying a constant rate) and blood volume controlled (cHD). The relative (RBV) was continuously monitored. individual limit (RBV crit...
Optimization of hemodialysis treatment parameters and the characteristics dialyzer are crucial for short- long-term outcome end stage renal disease patients. The new high-flux membrane Helixone ® in FX series (Fresenius Medical Care, Germany) has interesting features, such as relationship thickness capillary diameter which increases middle molecule elimination by convection, well higher packing microondulation to improve dialysate flow distribution. Blood flow, surface area main determinants...
Background:Residual renal function (RRF) affects sodium and fluid balance. The aim of this analysis was to examine the impact RRF on effect a sodium-reduced peritoneal dialysis (PDF) blood pressure (BP).Methods:This is post-hoc prospective, randomized, controlled double-blind clinical trial with 82 patients continuous ambulatory PD (CAPD) treated low-sodium (125 mmol/L Na) or standard-sodium (134 PDF. Subgroups according glomerular filtration rate (GFR) at baseline (≤ / > 6 mL/min/1.73 m2)...