Next to a high morbidity, patients with end-stage renal failure (ESRD) suffer from complex spectrum of clinical manifestations. Both the phenotype ESRD as well pathophysiology uremia show interesting parallels general aging process. Phenotypically, have an increased susceptibility for both cardiovascular infectious disease and reduction in functional capacity muscular mass (sarcopenia), translating into prevalence frailty also younger patients. Pathophysiologically, immune dysfunction,...

We have found previously that in acute myocardial infarction (AMI), cardiac troponin T (cTnT) is degraded a time-dependent pattern. investigated whether cTnT forms differed patients with chronic increases, as seen renal dysfunction, from those the phase of infarction.We separated by gel filtration chromatography (GFC) end-stage disease (ESRD) patients: prehemodialysis (pre-HD) and post-HD (n = 10) 2 months follow-up 6). Purified standards, quality control materials clinical immunoassay...

Background Haemodialysis (HD) patients are predisposed to dysregulated fluid balance leading extracellular water (ECW) expansion. Fluid overload has been closely linked with outcome in these patients. This mainly attributed cardiac volume overload, but the relation between abnormalities status micro- and macrovascular dysfunction not studied detail. We interaction of macro- microvascular factors states normal over- hydration HD-dependent CKD. Methods compartments [total body (TBW) ECW]...

Physical inactivity in end-stage renal disease (ESRD) patients is associated with increased mortality, and might be related to abnormalities body composition (BC) physical performance. It uncertain what extent starting dialysis influences the effects of ESRD on activity (PA). This study aimed compare PA performance between stage 5 chronic kidney (CKD-5) non-dialysis patients, healthy controls, assess alterations during transition from CKD-5 dialysis, relate BC.For cross-sectional analyses 44...

Poor nutritional status is frequently observed in end-stage renal disease patients and associated with adverse clinical outcomes increased mortality. Loss of amino acids (AAs) during hemodialysis (HD) may contribute to protein malnutrition these patients.We aimed assess the extent AA loss HD consuming their habitual diet.Ten anuric chronic (mean ± SD age: 67.9 19.3 y, BMI: 23.2 3.5 kg/m2), undergoing 3 times per week, were selected participate this study. Spent dialysate was collected...

The first year following the start of haemodialysis (HD) is associated with increased mortality, especially during 90–120 days after dialysis. Whereas dialysis has important effects on internal environment patient, there are relatively few studies assessing changes in phenotype and underlying mechanisms transition period pre-dialysis to care, although more insight into these parameters importance unravelling causes this early mortality. In review, cardiovascular, nutritional inflammatory HD,...

Physical component summary (PCS) and mental (MCS) scores are associated with hospitalization mortality in patients end-stage renal disease. Most studies these cross-sectional nature. This study aimed to assess the dynamics of health-related quality life (HRQOL) over time, as well determinants changes HRQOL. Also, relation between HRQOL respect both was assessed.A analysis performed 77,848 hemodialysis (HD) whereas were assessed 8,339 a 1-year time period. measurements Kidney Disease Quality...

Background Cardiovascular disease (CVD) related mortality and morbidity are high in end-stage renal (ESRD). The pathophysiology of CVD ESRD may involve non-traditional risk factors, such as accumulation advanced glycation endproducts (AGEs), dicarbonyls, endothelial dysfunction (ED) low-grade inflammation (LGI). However, detailed data on the relation AGEs dicarbonyls with ED LGI limited. Methods We examined cross-sectional Spearman’s rank correlations serum biomarkers 43 individuals chronic...

Prevalent dialysis patients have low scores of health-related quality life (HRQOL) which are associated with increased risk hospitalization and mortality. Also in CKD-5 non-dialysis patients, HRQOL seem to be lower as compared the general population. This study firstly aimed compare between prevalent a cross-sectional analysis assess longitudinal changes over 1 year after initiation. Secondly, correlation physical activity (PA) was explored.Cross-sectional 44 non-dialysis, 29 dialysis, 20...

Serotonin is well known for its role in affection, but less cognition. The serotonin transporter (SERT) has an essential serotonergic neurotransmission as it determines the magnitude and duration of signal synaptic cleft. There evidence to suggest that homozygous SERT knockout rats (SERT(-/-)), humans with short allele, show stronger cognitive effects than wild-type control (SERT(+/+)) long allele after acute tryptophan depletion. In rats, genotype affect brain levels, SERT(-/-) having lower...

Seasonal variations in blood pressure (BP) and inter-dialytic weight gain (IDWG) are well established dialysis patients. However, no study has assessed changes body composition (BC) this population.In survey, seasonal fat mass (FM), lean tissue (LTM), extracellular water (ECW) fluid overload (FO) were 42 099 patients (mean age 61.2 years, 58% males) from the Fresenius Medical Care Europe database, as part of MONitoring Dialysis Outcomes (MONDO) consortium, relation to other nutritional...

Introduction The concentration of dialysate calcium (dCa) has been suggested to affect vascular calcification, but evidence is scarce. Calcification propensity reflects the intrinsic capacity serum prevent and phosphate precipitate. use citric-acid may have a beneficial effect on calcification due chelating magnesium. aim this study was compare intradialytic short-term effects haemodialysis with either standard acetic-acid dCa1.50 (A1.5) or dCa1.25 (A1.25), as well (C1.5) in bicarbonate...

There is a paucity of prognostic models for COVID-19 that are usable in-office patient assessment in general practice (GP).

Introduction End-stage renal disease (ESRD) strongly associates with cardiovascular (CVD) risk. This risk is not completely mitigated by replacement therapy. Endothelial dysfunction (ED) and low-grade inflammation (LGI) may contribute to the increased CVD However, data on serum biomarkers of ED LGI during transition therapy (dialysis kidney transplantation) are scarce. Methods We compared between 36 controls, 43 participants chronic (CKD) stage 5 non-dialysis (CKD5-ND), 20 CKD hemodialysis...

Patients with end-stage renal disease (ESRD) undergoing hemodialysis experience a rapid decline in skeletal muscle mass and strength. Hemodialysis removes amino acids (AAs) from the circulation, thereby lowering plasma AA concentrations stimulating proteolysis. In present study, we evaluate impact of intradialytic protein ingestion at rest following exercise on removal availability patients ESRD. Ten (age: 65 ± 16 y, male/female: 8/2, BMI: 24.2 4.8 kg/m2, serum albumin: 3.4 0.3 g/dL) ESRD...

Prospective studies combining physical functioning (PF), activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients their donors by examining changes the first post-operative year both groups. Twenty-two 22 healthy were included this prospective longitudinal with a follow-up until twelve months. PF was assessed handgrip strength (HGS), domains of health-related quality...

<b><i>Introduction:</i></b> It is widely known that dialysis patients have significantly impaired functional outcomes and arterial stiffness, but still few studies investigated the effects of longitudinally by a multidimensional approach. We aimed to assess longitudinal patterns physical activity (PA), functioning (PF), health-related quality life (HrQoL), body composition (BC), stiffness in prevalent patients. <b><i>Materials Methods:</i></b>...

Chronic kidney disease patients show changes in the endothelial surface layer (ESL). Whether hemodialysis (HD) itself or low molecular weight heparins (LMWH) induce ESL alterations is unknown.We studied 20 HD with Sidestream Dark Field Imaging [measuring perfused boundary region (PBR)] and measurement of constituents plasma during 2 studies. LMWH was administered at start study A, 120 min after B. Mean platelet volume (MPV) large cell ratio (P-LCR) were also measured.Syndecan-1 increased...

Cardiovascular disease is a major contributor to the poor outcomes observed in hemodialysis. We investigated relationship between hemodialysis intensity and vascular parameters high-dose (HDHD; >12hrs/week) Conventional (CHD; ≤12hrs/week) over 6-month period.We present longitudinal analysis of 2-year multicenter study investigating effects HDHD on cardiovascular parameters. used pulse wave velocity, 24hr ambulatory blood pressure sublingual dark field capillaroscopy measurements assess...

End-stage renal disease (ESRD) is strongly associated with cardiovascular (CVD) risk. Advanced glycation endproducts (AGEs) and dicarbonyls, major precursors of AGEs, may contribute to the pathophysiology CVD in ESRD. However, detailed data on courses AGEs dicarbonyls during transition ESRD patients replacement therapy are lacking. We quantified an extensive panel free protein-bound serum [N ∈-(carboxymethyl)lysine (CML), N ∈-(carboxyethyl)lysine (CEL),...

<b><i>Background:</i></b> Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients not assessed in detail. <b><i>Methods:</i></b> We report baseline demographic and CV phenotype 36 CHD EHD participants a longitudinal multicentre study. measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark-field capillaroscopy...