A5072107327- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Neurogenesis and neuroplasticity mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Adipose Tissue and Metabolism
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Birth, Development, and Health
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Attention Deficit Hyperactivity Disorder
- Mitochondrial Function and Pathology
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2004-2024
Pro Persona
2024
Allen Institute for Brain Science
2023
Netherlands Institute for Neuroscience
2016-2018
University of Amsterdam
1998-2016
Royal Netherlands Academy of Arts and Sciences
2016
Amsterdam UMC Location University of Amsterdam
2016
Maastricht University
2016
The rat is one of the most important model organisms for biomedical and pharmacological research. However, generation novel models studying specific aspects human diseases largely depends on selection traits using existing strains, thereby solely depending naturally occurring variation. This study aims to provide tools manipulate genome in a more directed way.We developed robust, automated, scaleable reverse genetic methodology based ENU (N-ethyl-N-nitrosourea)-driven target-selected...
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive compulsive mania, drug addiction, eating disorders, and substance abuse as well chronic pain. To ensure progress the understanding of neuropathophysiology these animals models with good construct predictive validity are indispensable. Many human studies aimed at measuring capacities use Iowa Gambling Task, task designed to model every-day...
Rats were the first mammalian species domesticated for scientific purposes, and they soon became most widely used animal model in biomedical sciences, including cardiovascular research behavioral neuroscience. Yet, after development of technologies to manipulate genes, researchers largely shifted use mice. However, as we lay out with examples from drug addiction, social behavior, research, rats have experimental advantages over With introduction zinc-finger nuclease (ZFN), transcription...