A5019270538- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Nerve injury and regeneration
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Cellular transport and secretion
- Diet and metabolism studies
- Ion channel regulation and function
- Congenital heart defects research
- Hypothalamic control of reproductive hormones
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
Inserm
2016-2025
Sorbonne Université
2013-2025
Institut du Cerveau
2017-2025
Centre National de la Recherche Scientifique
2023-2025
Institut de Psychiatrie et Neurosciences de Paris
2020-2024
Institut du Fer à Moulin
2014-2023
University of Chile
2023
Universidade Regional do Cariri
2022
Portuguese Sea and Atmosphere Institute
2022
Pontifícia Universidade Católica de Campinas
2022
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior men of a Dutch family. line transgenic mice was isolated which transgene integration caused deletion the gene encoding MAOA, providing animal model MAOA deficiency. In pup brains, concentrations were increased up ninefold, serotonin-like immunoreactivity present catecholaminergic neurons. adult norepinephrine twofold,...
The organization of the cortical monoamine systems, dopamine (DA), and noradrenaline (NA), which have been studied extensively in rat more recently monkey, had not yet investigated directly human brain. We report here first systematic account regional laminar distributions catecholamine fibers cerebral cortex, using immunohistochemistry biosynthetic enzymes, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) 13 cytoarchitectonic areas (4, 6, 9, 3b, 5, 40, 17, 18, 23, 24, 29, insula,...
Serotoninergic innervation of the central nervous system is provided by hindbrain raphe nuclei (B1–B9). The extent to which each subdivision has distinct topographic organization their projections still unclear. We provide a comprehensive description main targets rostral serotonin (5-HT) subgroups (B5–B9) in mouse brain. Adeno-associated viruses that conditionally express GFP under control 5-HT transporter promoter were used label small groups neurons dorsal (B7d), ventral (B7v), lateral...
The dopaminergic input to the frontal cortex has an important role in motor and cognitive functions. These effects are mediated by dopamine receptors both of type D1 D2, although neural circuits involved not completely understood. We used situ hybridization determine cellular localization D2 receptor mRNAs rat cortex. Retrograde tracing was same animals identify main cortical efferent populations. Fluorogold injected into different targets sections were hybridized with 35S-labelled cRNA...
Deficiency in the monoamine degradation enzyme oxidase A (MAOA) or prenatal exposure to uptake inhibitor cocaine alters behavior humans and rodents, but mechanisms are unclear. In MAOA knock-out mice, inhibiting serotonin synthesis during development can prevent abnormal segregation of axons retinogeniculate somatosensory thalamocortical systems. To investigate this effect, we crossed knock-outs with mice lacking transporter 5-HTT 5-HT1B receptor, two molecules present developing sensory...
Abstract The regional density and laminar distribution of dopamine (DA) serotonin (5‐HT) afferents were investigated in the cerebral cortex cynomolgus monkeys using a radioautographic technique that is based on high affinity uptake capacity these aminergic neurons. Large vibratome sections, 50 μm thick, incubated with [ 3 H] DA (0.2 μM) desipramine (5 or unlabeled norepinephrine 5‐HT (0.6 μM), which allowed for specific labeling innervations, respectively. After fixation, sections dried,...
Abstract The motor areas of the cerebral cortex contain dense dopaminergic and noradrenergic innervation in humans. We looked for changes these innervations cases with Parkinson's disease (PD). density fibers immunolabeled tyrosine hydroxylase or dopamine‐beta‐hydroxylase was evaluated primary motor, premotor, prefrontal cortical regions 6 PD 7 control cases. Reductions both were observed, similar magnitudes reduction found cortex. Depletion diffuse, involving all laminae. laminar specific,...
Abstract The sources and histochemical characteristics of dopaminergic projections to motor premotor areas cortex were investigated in owl monkeys which information from related studies was used subdivide into fields. Brainstem frontal identified by injections different fluorescent dyes the primary (M1) supplementary area (SMA), first microstimulation. Injections also placed dorsal lateral prefrontal cortex. distribution retrogradely labeled neurons location tyrosine hydroxylase...
The catecholaminergic innervation of the human septal area and closely related structures has been visualized by using tyrosine hydroxylase (TH) dopamine-beta-hydroxylase (DBH) as immunocytochemical markers. TH-like immunoreactivity with no corresponding DBH labelling was considered to be indicative dopaminergic fibers. Catecholaminergic offered following similarities that rodents: moderate in medial division, predominant immunolabelling; dense lateral nuclei, organized a laminar pattern;...
The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities this structure. Midline glial cells are known to play role development, but we here show two transient populations midline neurons also make major contributions formation commissure. We report these neuronal enter prior arrival callosal pioneer axons. Using combination...
Exposure to stress during early life (infancy/childhood) has long-term effects on the structure and function of prefrontal cortex (PFC), increases risk for adult depression anxiety disorders. However, little is known about molecular cellular mechanisms these effects. Here, we focused changes induced by chronic maternal separation first 2 weeks postnatal life. Unbiased mRNA expression profiling in medial PFC (mPFC) maternally separated (MS) pups identified an increased myelin-related genes a...
Heterogeneity of central serotonin (5-HT) raphe neurons is suggested by numerous lines evidence, but its genetic basis remains elusive. The transcription factor Pet1 required for the acquisition serotonergic identity in a majority nuclei. Nevertheless, subset 5-HT differentiates knock-out mice. We show here that these residual outline unique subpopulation with highly selective anatomical targets and characteristic synaptic differentiations. In mice, innervation strikingly outlines brain...