A5069738672- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Obsessive-Compulsive Spectrum Disorders
- Epigenetics and DNA Methylation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetic Associations and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Adrenal Hormones and Disorders
- Genetic Neurodegenerative Diseases
- Mental Health Research Topics
- Growth Hormone and Insulin-like Growth Factors
Maastricht University
2016-2025
Universitätsklinikum Würzburg
2015-2025
University of Würzburg
2015-2024
Sechenov University
2016-2023
Computer Professionals for Social Responsibility
2023
Radboud University Medical Center
2011-2019
Radboud University Nijmegen
2011-2019
Massachusetts General Hospital
2019
Sunovion (United States)
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety humans and animal models is the site action widely used uptake-inhibiting antidepressant antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription modulated by a common polymorphism its upstream regulatory region. The short variant reduces transcriptional efficiency 5-HTT promoter, resulting decreased expression lymphoblasts. Association studies two independent samples totaling...
Abstract: Mood, emotion, cognition, and motor functions as well circadian neuroendocrine rhythms, including food intake, sleep, reproductive activity, are modulated by the midbrain raphe serotonin (5‐HT) system. By directing magnitude duration of postsynaptic responses, carrier‐facilitated 5‐HT transport into release from presynaptic neuron essential for fine tuning serotonergic neurotransmission. Interest in mechanism environmental factor‐, disease‐, therapy‐induced modification transporter...
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT) provides the primary mechanism for inactivation of 5-HT after its release into synaptic cleft. To further evaluate function 5-HTT, murine gene was disrupted by homologous recombination. Despite evidence that excess extracellular during embryonic development, including produced drugs inhibit may lead to severe craniofacial and cardiac malformations, no obvious developmental phenotype observed in...
A genetic contribution to the pathogenesis of panic disorder has been demonstrated by clinical studies. Molecular studies have focused on candidate genes suggested molecular mechanisms implied in action drugs utilized for therapy or challenge tests. One class effective treatment is represented monoamine oxidase inhibitors. Therefore, gene chromosome X a prime gene. In present study we investigated novel repeat polymorphism promoter association with two independent samples (German sample, n =...
Abstract: A cDNA encoding the human platelet serotonin (5‐HT) uptake site was isolated and sequenced using PCR. The represents a ˜3.1‐kb mRNA transcript contains an open reading frame hydrophobic polypeptide of 630 amino acids with 12 membrane‐spanning segments, calculated molecular mass 70,320 Da, estimated isoelectrical point 5.84. 5‐HT is identical brain transporter ˜92% homologous to rat protein. Hydropathicity analysis indicates segments two putative glycosylation sites within second...
Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, norepinephrine. also blocks voltage-gated sodium channels, a property not shared methylphenidate. Several lines of evidence have suggested that cocaine blockade the dopamine transporter (DAT), perhaps with additional contributions from serotonin (5-HTT) recognition, was key to its rewarding actions. We now report knockout mice without DAT 5-HTT establish cocaine-conditioned place...
Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). reward/reinforcement has been linked to actions at DAT or blockade of SERT. However, knockouts neither DAT, SERT, NET reduce cocaine reward/reinforcement, leaving substantial uncertainty about cocaine's molecular mechanisms reward. Conceivably, the bases reward might display sufficient redundancy that either SERT be able mediate in other's absence. To test this...