A5082819414- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Health, Environment, Cognitive Aging
- Maternal Mental Health During Pregnancy and Postpartum
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- COVID-19 Impact on Reproduction
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- COVID-19 and healthcare impacts
- Neonatal and fetal brain pathology
- Genomic variations and chromosomal abnormalities
- Assisted Reproductive Technology and Twin Pregnancy
- Trauma and Emergency Care Studies
University of Oslo
2018-2024
Oslo University Hospital
2018-2022
University of Oxford
2019
Oxford Health NHS Foundation Trust
2019
Akershus University Hospital
2019
Diakonhjemmet Hospital
2019
University College London
2015
Significance Pregnancy is one of the most dynamic periods in a woman’s life, involving remarkable potential for brain plasticity that promotes cognitive and emotional adjustments to newborn. We provide evidence relationship between number childbirths aging 12,021 middle-aged women, suggesting parity-related changes may endure beyond postpartum period influence course neurobiological aging.
Longitudinal neuroimaging studies of major depressive disorder (MDD) have most commonly assessed the effects antidepressants from serotonin reuptake inhibitor class and usually reporting a single measure. Multimodal assessments were acquired MDD patients during an acute episode with serial measures 12-week treatment serotonin-norepinephrine (SNRI) duloxetine. Participants medication-free (n = 32; mean age 40.2 years) in healthy controls matched for age, gender, IQ 25; 38.8 years). received...
Abstract A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) bipolar (BD) spectrum disorders. However, multivariate relationships peripheral inflammatory/immune-related markers domains are unclear, many studies do not account for inter-individual variance both functioning inflammatory/immune status. This study aimed to investigate covariance patterns further...
Abstract Previous structural and functional neuroimaging studies have implicated distributed brain regions networks in depression. However, there are no robust imaging biomarkers that specific to depression, which may be due clinical heterogeneity neurobiological complexity. A dimensional approach fusion of modalities yield a more coherent view the neuronal correlates We used linked independent component analysis fuse cortical macrostructure (thickness, area, gray matter density), white...
Various patterns of structural brain abnormalities have been associated with depression, yet sensitive, specific and clinically predictive correlates proven to be difficult characterize.1 The currently best available empirical evidence on neuroanatomical differences between patients major depression (MDD) healthy controls are two meta-analyses approximately 10 000 individuals.2, 3 These reports show widespread alterations in cortical regions hippocampal volume, but no associations severity...
Abstract Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated loci, including the first linked to midbrain, pons, medulla oblongata volumes, map them 305 genes. In replication 7432 participants most loci show same effect direction are significant at nominal threshold. We detect overlap...
Attentional bias modification (ABM) may lead to more adaptive emotion perception and regulation. Understanding the neural basis of these effects greater precision for development future treatments. Task-related functional MRI (fMRI) after ABM training has not been investigated in depression so far. The main aim this randomized controlled trial was explore differences brain activity training, response emotional stimuli.A total 134 people with previous depression, who had treated various...
Following treatment, many depressed patients have significant residual symptoms. However, large randomised controlled trials (RCT) in this population are lacking. When Attention bias modification training (ABM) leads to more positive emotional biases, associated changes clinical symptoms been reported. A broader and transparent picture of the true advantage ABM based on larger stringent requested. The current study evaluates early effect two weeks blinded clinician-rated self-reported...
Numerous genetic and environmental factors contribute to psychiatric disorders other brain disorders. Common risk likely converge on biological pathways regulating the optimization of structure function across lifespan. Here, using structural magnetic resonance imaging machine learning, we estimated gap between age chronological in 36,891 individuals aged 3 96 years, including with different We show that several are associated accentuated aging, strongest effects schizophrenia, multiple...
Alterations in resting state networks (RSNs) are associated with emotional- and attentional control difficulties depressed individuals. Attentional bias modification (ABM) training may lead to more adaptive emotional processing depression, but little is known about the neural underpinnings ABM. In current study a sample of 134 previously individuals were randomized into 14 days computerized ABM- or closely matched placebo regime followed by magnetic resonance imaging (MRI) scan. Using...
Abstract The human thalamus is an integrative hub for multiple cortical and subcortical circuits involved in both sensory processing higher cognitive functions. Group-level thalamic volume differences have been reported psychiatric neurological disorders, but previous studies relied on small samples, covered few or only investigated the whole without considering subdivisions. In this multi-site study, we compared nuclei volumes across several disorders (N = 5 094) healthy controls 4 552)....
Abstract Purpose The COVID-19 pandemic has impacted medication needs and prescribing practices, including those affecting pregnant women. Our goal was to investigate patterns of use among women with COVID-19, focusing on variations by trimester infection location. Methods We conducted an observational study using six electronic healthcare databases from European regions (Aragon/Spain; France; Norway; Tuscany, Italy; Valencia/Spain; Wales/UK). prevalence primary care or dispensing compared in...
Abstract Pregnancy and childbirth involve maternal brain adaptations that promote attachment to protection of the newborn. Using imaging machine learning, we provide evidence for a positive relationship between number childbirths ‘younger-looking’ in 12,021 women, which could not be explained by common genetic variation. The findings demonstrate parity can linked health later life.
Abstract Background Depression is a complex disorder with large inter-individual variability in symptom profiles that often occur alongside symptoms of other psychiatric domains such as anxiety. A dimensional and symptom-based approach may help refine the characterization classification depressive anxiety disorders thus aid establishing robust biomarkers. We assess brain functional connectivity correlates clustering individuals using imaging data. Methods assessed depression Beck’s Anxiety...
Abstract Frailty is a dementia risk factor commonly measured by frailty index (FI). The standard procedure for creating an FI requires manually selecting health deficit items and lacks criteria selection optimization. We hypothesized that refining the item using data-driven assessment improves sensitivity to cognitive status future conversion, compared predictive value of three FIs: 93-item was created after according (FI s ) from ADNI database. A refined r calculated subset items,...
Abstract Background Modification of attentional biases (ABM) may lead to more adaptive emotion perception and regulation. Understanding the neural basis these effects greater precision for future treatment development. Task-related fMRI following ABM training has so far not been investigated in depression. The main aim RCT was explore differences brain activity after response emotional stimuli. Methods A total 134 previously depressed individuals were randomized into 14 days ABM- or a...
Abstract Cognitive abilities and mental disorders are complex traits sharing a largely unknown neuronal basis aetiology. Their genetic architectures highly polygenic overlapping, which is supported by heterogeneous phenotypic expression substantial clinical overlap. Brain network analysis provides non-invasive means of dissecting biological heterogeneity yet its sensitivity, specificity validity in applications remains major challenge. We used machine learning on static dynamic temporal...
ABSTRACT Brainstem regions support critical bodily functions, yet their genetic architectures and involvement in brain disorders remain understudied. Here, we examined volumes of brainstem structures using magnetic resonance imaging 43,353 individuals. In 27,034 genotyped healthy participants, identified 16 loci associated with whole volume 10, 23, 3, 9 the midbrain, pons, superior cerebellar peduncle, medulla oblongata, respectively. These were mapped to 305 genes, including genes linked...
Norwegian health registries covering entire population are used for administration, research, and emergency preparedness. We harmonized these data onto the Observational Medical Outcomes Partnership common model (OMOP CDM) enrich real-world in OMOP format with COVID-19 related data.
Background Following treatment, many depressed patients have significant residual symptoms. However, large randomised controlled trials (RCT) in this population are lacking. When Attention bias modification training (ABM) leads to more positive emotional biases, associated changes clinical symptoms been reported. A broader and transparent picture of the true advantage ABM based on larger stringent requested. Aims To evaluate early effect two weeks blinded clinician-rated self-reported...