A5018235068- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Experimental Behavioral Economics Studies
- Enzyme Production and Characterization
- Malaria Research and Control
- Diet and metabolism studies
- Evolutionary Game Theory and Cooperation
- Geology and Paleoclimatology Research
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
- Cryospheric studies and observations
- Protein Hydrolysis and Bioactive Peptides
- Ion channel regulation and function
- Diet, Metabolism, and Disease
- Enzyme Structure and Function
- Biofuel production and bioconversion
- Cholesterol and Lipid Metabolism
- Proteins in Food Systems
- Evolutionary Psychology and Human Behavior
- Biochemical effects in animals
- Gastrointestinal motility and disorders
- Bone Metabolism and Diseases
- Mosquito-borne diseases and control
- Receptor Mechanisms and Signaling
Tokyo University of Agriculture
2016-2025
National Cancer Center Hospital East
2025
National Cancer Institute
2025
Center for Cancer Research
2025
Himeji Medical Center
2022-2024
Keio University
2023-2024
Resonac (Japan)
2024
Keio University Hospital
2024
Hokkaido University
2009-2023
Mitsubishi Electric (Japan)
1997-2023
The classical exchange theorists proposed that trust is more likely to develop between partners when occurs without explicit negotiations or binding agreements. Under these conditions, the risk and uncertainty of provide opportunity for demonstrate their trustworthiness. This study develops theoretical implications this proposition conducts an experimental test compares levels both commitment in two forms direct exchange, negotiated reciprocal. results support proposition, showing reciprocal...
The ability of mammals to resist body fat accumulation is linked their expand the number and activity "brown adipocytes" within white depots. Activation β-adrenergic receptors (β-ARs) can induce a functional "brown-like" adipocyte phenotype. As cardiac natriuretic peptides (NPs) β-AR agonists are similarly potent at stimulating lipolysis in human adipocytes, we investigated whether NPs could mouse adipocytes acquire brown features, including capacity for thermogenic energy expenditure...
Abstract. CD44 has been identified as a membrane-binding partner for ezrin/radixin/moesin (ERM) proteins, plasma membrane/actin filament cross-linkers. ERM however, are not necessarily colocalized with in tissues, but CD43 and ICAM-2 some types of cells. We found that glutathione-S-transferase fusion proteins the cytoplasmic domain ICAM-2, well CD44, bound to moesin vitro. The regions responsible vitro binding were narrowed down their juxta-membrane 20–30–amino acid sequences domain. These...
Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa receptor subtypes are circuits that can modulate nociception receive inputs from endogenous opioid neuropeptide ligands. The roles played by each subtype processing drug-free morphine-treated states have not been clear, however. We produced homologous, recombinant receptor, heterozygous homozygous knockout animals displayed approximately 54% 0% of wild-type levels mu expression,...
Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, norepinephrine. also blocks voltage-gated sodium channels, a property not shared methylphenidate. Several lines of evidence have suggested that cocaine blockade the dopamine transporter (DAT), perhaps with additional contributions from serotonin (5-HTT) recognition, was key to its rewarding actions. We now report knockout mice without DAT 5-HTT establish cocaine-conditioned place...
The brain vesicular monoamine transporter (VMAT2) pumps neurotransmitters and Parkinsonism-inducing dopamine neurotoxins such as 1-methyl-4-phenyl-phenypyridinium (MPP + ) from neuronal cytoplasm into synaptic vesicles, which amphetamines cause their release. Amphetamines MPP each also act at nonvesicular sites, providing current uncertainties about the contributions of actions to in vivo effects. To assess amphetamine-induced locomotion, reward, sequestration resistance dopaminergic...
The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and consumption. Here, we demonstrate that receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases abdominal fat pads fasting plasma triglycerides. Daily spontaneous motor activity of Oxtr-/- were not significantly different compared wild-type mice. In contrast, brown adipose tissue contained large lipid droplets cold-induced thermogenesis was impaired. This study...
Abstract Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) classical brown ectopic beige adipocytes controlled sympathetic nervous system (SNS). Previous work indicated that fish oil intake reduces fat accumulation induces UCP1 expression BAT; however, detailed mechanism this effect remains unclear. In study,...
A well balanced body energy budget controlled by limitation of calorie uptake and/or increment expenditure, which is typically achieved proper physical exercise, most effective against obesity and diabetes mellitus. Recently, peroxisome proliferator-activated receptor (PPAR) γ, a member the nuclear receptor, its cofactors have been shown to be involved in lipid metabolism control expenditure. Here we show that PPARγ coactivator 1 (PGC-1) β functions as ERRL1 (for ERR l igand ), can bind...
The existence of generalized exchange characterized by unilateral resource giving has been a puzzle when we assume rational actors, because free riding can occur. This article first identifies pure-generalized in which each actor gives resources to the recipient(s) his choice. Then, it proposes fairness-based selective-giving strategy. An adopting this strategy selects recipient whose behaviors satisfy her criterion fairness, provided perfect information is given. results evolutionary...
While classical exchange theorists excluded bargaining from the scope of their theories, most contemporary have done opposite, concentrating exclusively on negotiated exchanges with binding agreements. We analyze how form social - or reciprocal affects distribution power in networks. These two forms differ fundamental ways that affect actors use and kinds risk uncertainty they face. predict these basic differences will relation between availability alternative partners actors' power, produce...
Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. We investigated the suppressive effects of fucoxanthin its metabolite, fucoxanthinol, on differentiation 3T3-L1 preadipocytes to adipocytes. inhibited intercellular lipid accumulation during adipocyte cells. Furthermore, was converted fucoxanthinol Fucoxanthinol also exhibited decreased glycerol-3-phosphate dehydrogenase activity, an indicator differentiation. The effect stronger...
Several herbal medicines improve hyperlipidemia, diabetes and cardiovascular diseases. However, the molecular mechanism underlying this improvement has not yet been clarified. In study, we found that several isoprenols, common components of plants, activate human peroxisome proliferator‐activated receptors (PPARs) as determined using novel GAL4 ligand‐binding domain chimera assay system with coactivator coexpression. Farnesol geranylgeraniol are typical isoprenols in herbs fruits activated...
Peroxisome proliferator-activated receptor-α (PPARα) is a dietary lipid sensor, whose activation results in hypolipidemic effects. In this study, we investigated whether PPARα affects energy metabolism white adipose tissue (WAT). Activation of by its agonist (bezafibrate) markedly reduced adiposity KK mice fed high-fat diet. 3T3-L1 adipocytes, addition GW7647, highly specific agonist, during adipocyte differentiation enhanced glycerol-3-phosphate dehydrogenase activity, insulin-stimulated...
Several herbal plants improve medical conditions. Such contain many bioactive phytochemicals. Terpenoids (also called "isoprenoids") constitute one of the largest families natural products accounting for more than 40,000 individual compounds both primary and secondary metabolisms. In particular, terpenoids are contained in plants, several have been shown to be available pharmaceutical applications, example, artemisinin taxol as malaria cancer medicines, respectively. Various not only use but...
Uncoupling protein (UCP)-1 expressed in brown adipose tissue plays an important role thermogenesis. Recent data suggest that brown-like adipocytes white (WAT) and skeletal muscle play a crucial the regulation of body weight. Understanding mechanism underlying increase UCP-1 expression level these organs should, therefore, provide approach to managing obesity. The thyroid hormone (TH) has profound effects on mitochondrial biogenesis promotes mRNA UCP tissue. However, action TH induction WAT...
Abstract In obesity, adipocyte hypertrophy and chronic inflammation in adipose tissues cause insulin resistance type‐2 diabetes. Trigonella foenum‐graecum (fenugreek) can ameliorate hyperglycemia However, the effects of fenugreek on size have not been demonstrated. this study, we determined diabetic obese KK‐Ay mice, identified active substance fenugreek. Treatment mice with a high fat diet supplemented 2% ameliorated Moreover, miniaturized adipocytes increased mRNA expression levels...
Emergence of thermogenic adipocytes such as brown and beige is critical for whole body energy metabolism. Promoting the emergence these adipocytes, which increase expenditure, could be a viable strategy in treating obesity its related diseases. However, little known regarding mechanisms that regulate obese adipose tissue. Here, we demonstrated classically activated macrophages (M1 Mϕ) suppress induction tissues mice. Cold exposure significantly induced expression levels uncoupling protein-1...
Because ≈90% of malaria cases occur in Africa, emergence artemisinin-resistant Plasmodium falciparum Africa poses a serious public health threat. To assess parasites Uganda during 2014-2016, we used the recently developed ex vivo ring-stage survival assay, which estimates ring-stage-specific P. susceptibility to artemisinin. We conducted 4 cross-sectional surveys artemisinin sensitivity Gulu, Uganda. Among 194 isolates, rates (ratio viable drug-exposed drug-nonexposed controls) were high...
Recently, it has been demonstrated that uncoupling protein-1 (UCP1)-expressing white adipocytes (brown-like adipocytes) are important for energy expenditure in adipose tissue (WAT), which decreases under obese conditions. However, the relationship between induction of brown-like and decrease WAT remains to be elucidated. Here, we show proinflammatory cytokines derived from activated macrophages suppress UCP1 promoter activity mRNA expression via an extracellular signal-related kinase (ERK)...