A5000709317- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Heart Failure Treatment and Management
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Pancreatic function and diabetes
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Glycosylation and Glycoproteins Research
- Pain Mechanisms and Treatments
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- GDF15 and Related Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Electrochemical Analysis and Applications
- Exercise and Physiological Responses
Capital Medical University
2022-2025
Vanderbilt University Medical Center
2019-2024
Nashville Oncology Associates
2024
Tianjin Medical University
2023
Discovery Institute
2016-2021
Sanford Burnham Prebys Medical Discovery Institute
2011-2021
Shihezi University
2021
Vanderbilt University
2019
Kunming University of Science and Technology
2017
Hunan University
2015
The ability of mammals to resist body fat accumulation is linked their expand the number and activity "brown adipocytes" within white depots. Activation β-adrenergic receptors (β-ARs) can induce a functional "brown-like" adipocyte phenotype. As cardiac natriuretic peptides (NPs) β-AR agonists are similarly potent at stimulating lipolysis in human adipocytes, we investigated whether NPs could mouse adipocytes acquire brown features, including capacity for thermogenic energy expenditure...
Nuclear factor E2-related 2 (Nrf2) is a cap-n-collar basic leucine zipper (CNC-bZIP) transcription that well established as master regulator of phase II detoxification and antioxidant gene expression strongly expressed in tissues involved xenobiotic metabolism including liver kidney. Nrf2 also abundantly adipose tissue; however, the exact function adipocyte biology unclear. In current study we show targeted knock-out mice decreases tissue mass, promotes formation small adipocytes, protects...
A classic metabolic concept posits that insulin promotes energy storage and adipose expansion, while catecholamines stimulate release of stores by hydrolysis triglycerides through β-adrenergic receptor (βARs) protein kinase (PKA) signaling. Here, we have shown a key hub in the signaling pathway, activation p70 ribosomal S6 (S6K1) mTORC1, is also triggered PKA both mouse human adipocytes. Mice with mTORC1 impairment, either adipocyte-specific deletion Raptor or pharmacologic rapamycin...
Prolonged exposure of rodent beta-cells to combinations cytokines induces the inducible form nitric oxide synthase (iNOS) expression and Fas expression, (NO) production, cell death. It also potential "defense" genes, such as manganese superoxide dismutase (MnSOD) heat shock protein (hsp) 70. NO is a radical with multifaceted actions. Recent studies have shown that NO, in addition having cytotoxic actions, may regulate gene transcription. remains unclear whether mediates cytokine-induced...
Uncoupling protein (UCP) 2 is a widely expressed mitochondrial whose precise function still unclear but has been linked to mitochondria-derived reactive oxygen species production. Thus, the chronic absence of UCP2 potential promote persistent accumulation and an oxidative stress response. Here, we show that Ucp2−/− mice on three highly congenic (N >10) strain backgrounds (C57BL/6J, A/J, 129/SvImJ), including two independently generated sources Ucp2-null animals, all exhibit increased...
Nuclear factor E2–related 2 (Nrf2) is a transcription that functions as master regulator of the cellular adaptive response to oxidative stress. Our previous studies showed Nrf2 plays critical role in adipogenesis by regulating expression CCAAT/enhancer-binding protein β and peroxisome proliferator–activated receptor γ. To determine development obesity associated metabolic disorders, incidence syndrome was assessed whole-body or adipocyte-specific Nrf2-knockout mice on leptin-deficient ob/ob...
Natriuretic peptide receptor C deficiency improves metabolism through signaling in adipose tissue, rather than skeletal muscle.
Little is known about the biological function of histone deacetylase 11 (HDAC11), which lone class IV HDAC. Here, we demonstrate that deletion HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging white (WAT). Consequently, HDAC11-deficient exhibit enhanced thermogenic potential and, response to high-fat feeding, attenuated obesity, improved insulin sensitivity, reduced hepatic steatosis. Ex vivo cell-based assays revealed catalytic activity suppresses BAT...
Objectives We investigated whether Angiotensin II (Ang II) modulates peripheral chemoreflex function through carotid body (CB) chemoreceptors in chronic heart failure (CHF).
Objective Cardiac natriuretic peptides (NPs) bind to two receptors (NPRA‐mediator of signaling; NPRC‐clearance receptor) whose ratio, NPRR (NPRA/NPRC), determines the NP bioactivity. This study investigated relationship receptor gene expression in adipose tissue and muscle with obesity glucose intolerance. Prospectively, also assessed whether changes thermogenic markers accompanied improvements insulin sensitivity. Methods A cross‐sectional subjects a wide range BMI tolerance ( n = 50) was...
Aims: The inability of pancreatic β-cells to secrete sufficient insulin in response glucose stimulation is a major contributing factor the development type 2 diabetes (T2D). We investigated both vitro and vivo effects deficiency nuclear factor-erythroid 2-related 1 (Nrf1) on β-cell function homeostasis. Results: Silencing Nrf1 leads pre-T2D phenotype with disrupted metabolism impaired secretion. Specifically, MIN6 stable knockdown (Nrf1-KD) isolated islets from β-cell-specific Nrf1-knockout...
Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels mitochondrial biogenesis white fat (termed 'browning'), has great therapeutic potential treat obesity its comorbidities because net energy expenditure. β-adrenergic-cAMP-PKA signaling long been known regulate these processes. Recently PKA-dependent activation mammalian target rapamycin complex (mTORC1) was shown be necessary for 'browning' as well proper development...
Here, we show that β adrenergic signaling coordinately upregulates de novo lipogenesis (DNL) and thermogenesis in subcutaneous white adipose tissue (sWAT), both effects are blocked mice lacking the cAMP-generating G protein-coupled receptor Gs (Adipo-GsαKO) adipocytes. However, UCP1 expression but not DNL activation requires rapamycin-sensitive mTORC1. Furthermore, β3-adrenergic agonist CL316243 readily thermogenic lipogenic genes cultured adipocytes, indicating additional regulators must...
Decay-accelerating factor (DAF) is a cell-associated C regulatory protein that protects host cells from autologous attack. It functions intrinsically in cell surface membranes to rapidly dissociate classical and alternative pathway C3 convertases whenever these amplifying enzymes assemble on surfaces. composed of four contiguous approximately 70 amino acid long regions termed short consensus repeats (SCRs) share homology with similar units other convertase proteins. attached the membrane by...
Abstract Background The nucleotide oligomerization domain (NOD)-like receptor family pyrin containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity multiple neuropathic models, but the function of NLRP3 diabetic (DNP) and regulation mechanism are still largely unknown. Epigenetic plays a vital role controlling gene expression. Ten-eleven translocation methylcytosine dioxygenase 2 (TET2) is DNA demethylase that transcriptional activation. TET2 also involved high...
The estrogen-related receptor alpha gene encodes a nuclear protein, ERR alpha, whose structure is closely related to the estrogen receptors. modulates (ER)-mediated signaling pathways both positively and negatively. It selectively expressed in variety of cell types during development adult tissues. We have previously shown that stimulates expression mouse uterus. In this study, we found stimulated by uterus heart but not liver. Estrogen also human breast endometrial lines. promoter contains...
Receptor oligomerization is important for ligand binding and signal transduction. CD44 a transmembrane protein present on many cell types. One of the ligands hyaluronic acid (HA). HA activity linked to cellular activation in some Clustering has been speculated be HA. However, molecular mechanisms converting from an inactive receptor active are not known. Here we report that PMA stimulates by inducing clustering followed covalent homodimerization surface. Covalent dimerization involves...