A5039488638- Rare-earth and actinide compounds
- Iron-based superconductors research
- Magnetic Properties of Alloys
- Magnetic and transport properties of perovskites and related materials
- Inorganic Chemistry and Materials
- Crystallization and Solubility Studies
- Advanced Condensed Matter Physics
- Topological Materials and Phenomena
- Physics of Superconductivity and Magnetism
- X-ray Diffraction in Crystallography
- Genomics, phytochemicals, and oxidative stress
- Magnetic properties of thin films
- 2D Materials and Applications
- Crystal Structures and Properties
- Thermodynamic and Structural Properties of Metals and Alloys
- Microwave Dielectric Ceramics Synthesis
- Thermal Expansion and Ionic Conductivity
- Superconductivity in MgB2 and Alloys
- Graphene research and applications
- Multiferroics and related materials
- Ferroelectric and Piezoelectric Materials
- Power System Reliability and Maintenance
- Glutathione Transferases and Polymorphisms
- Advanced Thermoelectric Materials and Devices
- Magnetic Properties and Applications
Baylor University
2001-2025
University of California, Irvine Medical Center
2025
University of Leicester
2023-2025
Hong Kong Eye Hospital
2024
University of California, Irvine
2007-2024
Chinese University of Hong Kong
2024
University of Hong Kong
2023-2024
INTI International University
2023
National Cancer Centre Singapore
2023
Hong Kong Jockey Club
2023
Strongly frustrated magnetism of the metallic pyrochlore oxide ${\mathrm{Pr}}_{2}{\mathrm{Ir}}_{2}{\mathrm{O}}_{7}$ has been revealed by single crystal study. While Pr $4f$ moments have an antiferromagnetic RKKY interaction energy scale $|{T}^{*}|=20\text{ }\text{ }\mathrm{K}$ mediated Ir $5d$-conduction electrons, no magnetic long-range order is found except for partial spin freezing at 120 mK. Instead, Kondo effect, including a $\mathrm{ln}T$ dependence in resistivity, emerges and leads to...
The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions, Keap1 recruits into the Cul3-containing E3 ubiquitin ligase complex for conjugation and subsequent proteasomal degradation. Oxidative stress triggers activation of through inhibition activity, resulting in increased levels transcriptional Nrf2-dependent genes. In this study, we identify as a key postinduction repressor demonstrate that nuclear export sequence (NES) is required termination...
Nuclear factor E2-related 2 (Nrf2) is a cap-n-collar basic leucine zipper (CNC-bZIP) transcription that well established as master regulator of phase II detoxification and antioxidant gene expression strongly expressed in tissues involved xenobiotic metabolism including liver kidney. Nrf2 also abundantly adipose tissue; however, the exact function adipocyte biology unclear. In current study we show targeted knock-out mice decreases tissue mass, promotes formation small adipocytes, protects...
The disruption of the NRF2 (nuclear factor erythroid-derived 2-like 2)/glutathione-mediated antioxidant defense pathway is a critical step in pathogenesis several chronic pulmonary diseases and cancer. While mechanism activation upon oxidative stress has been widely investigated, little known about endogenous signals that regulate lung physiology pathology. Here we show an E-box-mediated circadian rhythm protein essential regulating rhythmic expression genes involved glutathione redox...
Recently, organolead halide-based perovskites have emerged as promising materials for optoelectronic applications, particularly photovoltaics, photodetectors, and lasing, with low cost high performance. Meanwhile, nanoscale photodetectors attracted tremendous attention toward realizing miniaturized systems, they offer sensitivity, ultrafast response, the capability to detect beyond diffraction limit. Here we report high-performance nanoscale-patterned perovskite implemented by nanoimprint...
We have devised a complementation assay in yeast to clone mammalian transcriptional activators and used it identify human basic leucine-zipper transcription factor that we designated Nrf1 for NF-E2-related 1. potentially encodes 742-aa protein displays marked homology the mouse NF-E2 factors. activates via binding sites cells. The ubiquitous expression pattern of range promoters containing motif suggest this gene may play role regulation heme synthesis ferritin genes.
Consumption of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) can mitigate the progression diseases in which oxidative stress represents a common underlying biochemical process. Nrf2-regulated gene expression regulates detoxification reactive oxygen species. EPA DHA were subjected to an vitro free radical oxidation process that models vivo conditions. Oxidized n-3 fatty acids reacted directly with negative regulator Nrf2, Keap1, initiating Keap1 dissociation Cullin3, thereby inducing...
Ferritin is a ubiquitous intracellular iron storage protein that consists of 24 subunits the H and L type. The ability to sequester from participation in oxygen free radical formation consistent with cytoprotective role for ferritin. Here we demonstrate ferritins are induced cells treated β-napthoflavone (β-NF) chemopreventive dithiolethiones. Induction ferritin by β-NF dithiolethiones oltipraz 1,2-dithiole-3-thione (D3T) occurs via transcriptional mechanism mediated...
Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE). Interestingly, TBH also rat GCLC, but promoter lacks ARE. This study examined role Nrf2 in transcriptional regulation GCLC. The baseline TBH-mediated increase mRNA levels activity were lower null (F1 F2) fibroblasts than wild-type cells. basal protein nuclear binding...
TCDD (2,3,7,8-tetrachlorodibenzo- p -dixoin) induces phase II drug-metabolizing enzyme NQO1 [NAD(P)H:quinone oxidoreductase; EC 1.6.99.2; DT-diaphorase] in a wide range of mammalian tissues and cells. Here, we analysed the molecular pathway mediating induction by mouse hepatoma Inhibition protein synthesis with CHX (cycloheximide) completely blocks as well basal expression phenolic antioxidant tBHQ (2-t-butylbenzene-1,4-diol), implicating labile factor mRNA expression. The inhibition is both...
Abstract Curcumin has been shown to prevent and inhibit carcinogen-induced tumorigenesis in different organs of rodent carcinogenesis models. Our objective is study global gene expression profiles elicited by curcumin mouse liver small intestine as well identify curcumin-regulated nuclear factor E2-related 2 (Nrf2)–dependent genes. Wild-type C57BL/6J Nrf2 knockout C57BL/6J/Nrf2(−/−) mice were given a single oral dose at 1,000 mg/kg. Liver collected 3 12 hours after treatments. Total RNA was...
Background Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial fungal infections excessive inflammation (e.g., inflammatory bowel disease). The mechanisms regulates not well understood. Methodology/Principal Findings We found that restrains modulating redox-sensitive innate immune pathways. When challenged with...
By means of alloying appropriate amounts MnNiSi and MnFeGe, materials are found that undergo a paramagnetic to ferromagnetic transition close room temperature, accompanied by huge volume change. Thanks this change, application moderate pressures leads remarkable enhancement the magnetocaloric response. Work like may open new opportunities in development solid-state magnetic refrigeration devices.
We report the crystal growth of well-faceted single crystals methylammonium lead iodide, CH3NH3PbI3, and detailed neutron diffraction structural studies aimed at elucidating orientation (CH3NH3+) cation in tetragonal cubic phases hybrid inorganic–organic perovskite. Room temperature experiments reveal a structure where protonated amine substituent (−NH3+) is disordered four positions, each preferentially located near neighboring iodine [PbI6] octahedra, while methyl (−CH3) eight positions...
Expression of antioxidant and phase 2 xenobiotic metabolizing enzyme genes is regulated through cis-acting sequences known as response elements. Transcriptional activation the elements involves members CNC (Cap 'n' Collar) family basic leucine zipper proteins including Nrf1 Nrf2. Nrf2 activity by Keap1-mediated compartmentalization in cell. Given structural similarities between Nrf2, we sought to investigate whether similarly also resides normally cytoplasm cells. Cytoplasmic localization...
The human homolog of mouse NF-E2 was isolated from the K562 cell line and found to encode a member basic leucine-zipper family DNA-binding regulatory proteins. deduced amino acid sequence proteins exhibited near identity. Comparison related protein, Nrf1, revealed significant homologies at regions, particularly within domain, suggesting that Nrf1 are members distinct subfamily share similar properties. High levels mRNA were observed in erythroleukemic lines examined. Extensive survey tissue...
Colony-stimulating factors (CSFs) are glycoproteins that stimulate the growth of hematopoietic progenitors and enhance functional activity mature effector cells. Human granulocyte/macrophage colony-stimulating factor (GM-CSF) is a 22-kDa glycoprotein stimulates myeloid erythroid in vitro increases responsiveness neutrophils, monocytes, eosinophils to physiologic stimuli. Elucidation cell tissue sources CSFs, as well study their regulation expression, required understand role pathophysiologic...
We have synthesized polycrystalline samples of the noncentrosymmetric superconductor ${\text{Mo}}_{3}{\text{Al}}_{2}\text{C}$ by arc and RF melting, measured its transport, magnetic thermodynamic properties, computed band structure. Experimental results indicate a bulk superconducting transition at ${T}_{c}\ensuremath{\sim}9.2\text{ }\text{K}$ while density states Fermi surface is found to be dominated $\text{Mo}\text{ }d$ orbitals. Using values for lower critical field ${H}_{c1}$, upper...
The central motivation of this manuscript is to highlight the discovery novel, highly correlated electron systems. Ternary phases with unusual ground states composed lanthanides, transition metals, and main group elements exhibit competing behavior leading potentially novel physical properties. These systems are known exotic properties such as unconventional superconductivity, heavy fermion behavior, forms magnetism. flux-growth method provides an avenue discover grow large single...