A5068228068- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Pain Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- GABA and Rice Research
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Plant-based Medicinal Research
- Psychedelics and Drug Studies
- Neuroendocrine regulation and behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Drug Transport and Resistance Mechanisms
- Ion channel regulation and function
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Biochemical effects in animals
Shonan University of Medical Sciences
2024
National Center of Neurology and Psychiatry
2008-2020
National Institute of Mental Health
2006-2020
National Institutes of Health
1996-2014
Hoshi University
1990-2014
Ebara (Japan)
1990-2014
Daiichi University of Pharmacy
1999-2001
National Institute on Drug Abuse
1996-1999
Johns Hopkins University
1997
Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa receptor subtypes are circuits that can modulate nociception receive inputs from endogenous opioid neuropeptide ligands. The roles played by each subtype processing drug-free morphine-treated states have not been clear, however. We produced homologous, recombinant receptor, heterozygous homozygous knockout animals displayed approximately 54% 0% of wild-type levels mu expression,...
Interactions between δ-opioid receptors and morphine-preferring μ-opioid receptor subtypes have been suggested. Availability of transgenic knockout mice allows assessment roles in the analgesia produced by classical agonist [d-Pen2,d-Pen5]enkephalin (DPDPE) hot-plate tail-flick tests. DPDPE was dramatically reduced a gene-dose-dependent fashion. The induced this classic depends on intact receptors, suggesting that selective drugs may require occupancies for full efficacy.
A transient decrease in cytosolic pH ([pH]i) rat parotid cells was evoked by the addition of carbachol (CCh), phenylephrine, or substance P, whereas isoproterenol and dibutyryl cyclic AMP had little no effect on [pH]¡. The [pH]i induced Ca2+-mobiIizing agonists also observed Ca2+-free medium, but not when intracellular Ca2+ stores were previously depleted. Ionomycin thapsigargin elicited a with an increase concentration ([Ca2+]i). protein kinase C activator inhibitor agonist-induced [pH]i....
Drug abusers most often smoke 'herbal incense' as a cigarette or inhale it using smoking tool. Smoking may cause pyrolysis of the drug and produce decomposed products which biological effect has never been investigated. The synthetic cannabinoid UR-144 is known to undergo thermal degradation, giving ring-opened isomer, so-called degradant. present study demonstrates by model that burned contains degradant showed approximately four fold higher agonist activity human CB1 receptor augmented...
Repeated doses of cocaine or amphetamine lead to long-lasting behavioral manifestations that include enhanced responses termed sensitization. Although biochemical mechanisms underlie these currently remain largely unknown, new protein synthesis has been implicated in several neuroadaptive processes. To seek candidate for drug-induced neuroplastic responses, we have used an approach subtracted differential display (SDD) identify genes whose expression is regulated by psychostimulants. rGβ 1...