A5020589454- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Fetal and Pediatric Neurological Disorders
- Sports injuries and prevention
- Flow Measurement and Analysis
- Optical measurement and interference techniques
- Oral and Maxillofacial Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Tumors and Oncological Cases
- Alzheimer's disease research and treatments
- Head and Neck Surgical Oncology
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Cardiovascular Effects of Exercise
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Image and Signal Denoising Methods
- Bone health and osteoporosis research
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Advanced Measurement and Detection Methods
Kyoto University
2003-2025
Neurocentre Magendie
2024
Université de Bordeaux
2021-2024
Inserm
2024
Kyushu University Hospital
2024
Institut des Maladies Neurodégénératives
2024
Centre National de la Recherche Scientifique
2024
Laboratoire Bordelais de Recherche en Informatique
2024
Centre Hospitalier Universitaire de Bordeaux
2024
Institut Polytechnique de Bordeaux
2024
Several herbal medicines improve hyperlipidemia, diabetes and cardiovascular diseases. However, the molecular mechanism underlying this improvement has not yet been clarified. In study, we found that several isoprenols, common components of plants, activate human peroxisome proliferator‐activated receptors (PPARs) as determined using novel GAL4 ligand‐binding domain chimera assay system with coactivator coexpression. Farnesol geranylgeraniol are typical isoprenols in herbs fruits activated...
The cAMP-response element-binding protein-binding protein (CBP) and p300 are common coactivators for several transcriptional factors. It has been reported that both CBP significant the activation of peroxisome proliferator-activated receptor γ (PPARγ), which is a crucial nuclear in adipogenesis. However, it remains unclear whether and/or physiologically essential to PPARγ adipocytes adipocyte differentiation. In this study, we investigated physiological significance CBP/p300 NIH3T3 cells...
Diffusion tensor imaging (DTI) and neurite orientation dispersion density (NODDI) are widely used models to infer microstructural features in the brain from diffusion-weighted MRI. Several studies have recently applied both increase sensitivity biological changes, however, it remains uncertain how these measures associated. Here we show that cortical distributions of DTI NODDI associated depending on choice b-value, a factor reflecting strength diffusion weighting gradient. We analyzed...
ABSTRACT PARK7/DJ-1 is a Parkinson disease- and cancer-associated protein that functions as multifunctional involved in gene transcription regulation anti-oxidative defense. Although PARK7 lacks the secretory signal sequence, it secreted plays important physiological pathophysiological roles. Whereas proteins lack endoplasmic reticulum-targeting sequence are from cells by way of what called unconventional secretion mechanism, specific processes responsible for causing to be across plasma...
To investigate the clinical and radiological features of immune checkpoint inhibitor-related pneumonitis (ICI-P), a rare but serious pulmonary complication cancer immunotherapy to evaluate key differences between lung (LC) non-LC patients.247 patients (LC, n = 151) treated with ICI for malignancies were retrospectively screened in single institute. The number patients, history other immune-related adverse events (irAE), onset, serum KL-6 levels, chest CT (types pneumonitis, symmetry,...
Compressed sensing (CS) reconstructions of under-sampled measurements generate missing data based on assumptions image sparsity. Non-contrast time-of-flight MR angiography (TOF-MRA) is a good candidate for CS acceleration, as MRA images feature bright trees sparse vessels over well-suppressed anatomical background signal. A short scan time derived from beneficial patients moyamoya disease (MMD) because the frequency scans. The purpose this study was to investigate reliability TOF-MRA with in...
Piceatannol (PIC), a natural analog of resveratrol (RES), is phytochemical found in passion fruit seeds. To clarify the effects PIC on obesity-induced inflammation adipose tissue, we investigated anti-inflammatory activity PIC-related compounds (PIC, RES, and metabolites from PIC) culture models obese tissue. Lipopolysaccharide (LPS) conditioned medium 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression synthesis nitric oxide (NO), tumor necrosis factor-α (TNF-α),...
Abstract Context Obesity is accompanied by damages to several tissues, including the brain. Pathological data and animal models have demonstrated an increased inflammatory reaction in hypothalamus hippocampus. Objective We tested whether we could observe such pathological modifications vivo through quantitative magnetic resonance imaging (MRI) metrics. Methods This prospective study was conducted between May 2019 November 2022. The Specialized Center for Care of a French University Hospital....
Abstract Ischemic strokes disrupt brain networks, leading to remote effects in key regions like the thalamus, a critical hub for functions. However, non-invasive methods quantify these consequences still need be explored. This study aimed demonstrate that MRI-derived R2* changes can capture iron accumulation linked with inflammation secondary stroke-induced disconnection. In order link disconnection, we first conducted analysis of 156 prospectively included stroke patients who underwent MRI...
Abietic acid is one of the terpenoids, which are multifunctional natural compounds. It has been reported that abietic suppresses effects on inflammation. However, mechanism underlying anti-inflammatory remains unclear. The present work indicates protein expression tumor necrosis factor-alpha and cyclooxygenase 2, involved in inflammation, lipopolysaccharide-stimulated macrophages. Moreover, this effect resembles thiazolidinedione, a synthetic peroxisome proliferator-activated receptor-gamma...
SUMMARY 1. The hypothesis that caffeine upregulates uncoupling protein (UCP)‐1, UCP‐2 and UCP‐3 expression, which contribute to thermogenesis, was investigated in obese mice. 2. mRNA levels of UCP‐1, ‐2 ‐3 brown adipose tissue (BAT), white (WAT), skeletal muscle were measured using real‐time quantitative reverse transcription–polymerase chain reaction analysis yellow KK mice 4 h after the subcutaneous administration either 60 mg/kg or physiological saline. Plasma free fatty acids,...
Thalamic atrophy can be used as a proxy for neurodegeneration in multiple sclerosis (MS). Some data point toward thalamic nuclei that could affected more than others. However, the dynamic of their changes during MS evolution and mechanisms driving differential alterations are still uncertain.
Objectives The aim of this study was to evaluate the clinical feasibility accelerated time-of-flight (TOF) magnetic resonance angiography with sparse undersampling and iterative reconstruction (sparse TOF). Materials Methods local institutional review board approved protocols. Twenty healthy volunteers were recruited (mean age, 31.2 years; age range, 22-52 14 men, 6 women). Both TOF parallel imaging (PI) obtained on a 3 T scanner. Acceleration factors 3, 4, 5, 6, 8 for (Sp 3×, Sp 4×, 5×, 6×,...
In Compressed Sensing (CS) of MRI, optimization the regularization parameters is not a trivial task. We aimed to establish method that could determine optimal weights for in CS time-of-flight MR angiography (TOF-MRA) by comparing various image metrics with radiologists' visual evaluation. TOF-MRA healthy volunteer was scanned using 3T-MR system. Images were reconstructed from retrospectively under-sampled data varying L1 norm wavelet coefficients and total variation. The images evaluated...
Neuronal activity was studied in the behaving active monkey to elucidate functional significance of catecholamines (CA) amygdala during reward-related behavior, and effects noradrenaline (NA), dopamine (DA), their antagonists, electrophoretically applied, were examined using multibarreled electrode techniques. The operant food intake task had four phases: 1) cue light on signal start bar pressing, 2) execution high fixed-ratio pressing (FR 20), 3) short tone triggered by last press...
Compressed sensing (CS) MRI has just been introduced to research areas as an innovative approach accelerate MRI. CS is expected achieve higher k-space undersampling by exploiting the underlying sparsity in appropriate transform domain. MR angiography (MRA) provides high spatial resolution information on arteries; however, a relatively long acquisition time necessary cover wide volume. Reduction of for time-of-flight (TOF) (Sparse-TOF) beneficial clinical examinations; therefore, validity...
<h3>Introduction</h3> Novel teleophthalmology technologies have the potential to reduce unnecessary and inaccurate referrals between community optometry practices hospital eye services as a result improve patients' access appropriate timely care. However, little is known about acceptability facilitators barriers implementations of these in real life. <h3>Methods analysis</h3> A theoretically informed, qualitative study will explore healthcare professionals' perspectives on Artificial...
Background A target mismatch profile can identify good clinical response to recanalization after acute ischemic stroke, but does not consider region specificities. Purpose To test whether location-weighted infarction core and mismatch, determined from diffusion perfusion MRI performed in patients with could improve prediction of mechanical thrombectomy compared a profile. Materials Methods In this secondary analysis, two prospectively collected independent stroke data sets (2012-2015...
Several concentrations of theobromine (TB) and (-)-epicatechin (EC) were coadministered to rats, plasma EC its metabolites determined using ultra-high-performance liquid chromatography-tandem mass spectrometry. It has been demonstrated that TB increases the absorption in a dose-dependent manner. Cocoa powder had similar effect, mechanism involved is not thought depend on tight junctions.
To compare quantitative values and image quality between single-shot echo-planar imaging (SS-EPI) diffusion-weighted (DWI) two-dimensional turbo gradient- spin-echo DWI with non-Cartesian BLADE trajectory (TGSE-BLADE DWI) in patients epidermoid cyst.
In this paper, we propose a robust sparsity-aware adaptive filtering algorithm under impulsive noise environment, by using the Huber loss function in frame of proximal forward-backward splitting (APFBS). The APFBS attempts to suppress time-varying cost which is sum smooth and nonsmooth function. As function, employ weighted functions output residuals. l 1 norm. use robustifies estimation norm effectively exploits sparsity system be estimated. resulting has low computational complexity with...
Abstract Although the Apiaceae herb family has been traditionally used for management of type 2 diabetes, its molecular mechanism not clarified. Coumarin derivatives, which are abundant in plants family, were evaluated their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production adiponectin, an anti‐diabetic adipokine. also demonstrated activates peroxisome proliferator‐activated receptor gamma (PPARγ), a master regulator...