A5058584860- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Neuroendocrine regulation and behavior
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Autism Spectrum Disorder Research
- Cognitive Abilities and Testing
- Evolutionary Psychology and Human Behavior
- Health, Environment, Cognitive Aging
- Attachment and Relationship Dynamics
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Bioinformatics and Genomic Networks
- Child and Adolescent Psychosocial and Emotional Development
- Personality Disorders and Psychopathology
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- EEG and Brain-Computer Interfaces
- Genetic Mapping and Diversity in Plants and Animals
- Neurotransmitter Receptor Influence on Behavior
- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
Oslo University Hospital
2017-2025
University of Oslo
2017-2025
University of Bergen
2023
National Center of Neurology and Psychiatry
2015-2018
Abstract Oxytocin is a neuropeptide involved in animal and human reproductive social behavior. Three oxytocin signaling genes have been frequently implicated behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), CD38 secretion). Here, we characterized the distribution of , mRNA across brain by creating voxel-by-voxel volumetric expression maps, identified putative pathway interactions comparing patterns 20,737 genes. Expression three selected was enriched subcortical...
Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices smaller subcortical volumes patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed the literature.To compare structural between individuals...
Abstract Estimating age based on neuroimaging‐derived data has become a popular approach to developing markers for brain integrity and health. While variety of machine‐learning algorithms can provide accurate predictions characteristics, there is significant variation in model accuracy reported across studies. We predicted two population‐based datasets, assessed the effects range, sample size age‐bias correction performance metrics Pearson's correlation coefficient ( r ), determination R 2...
Abstract The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer’s disease (AD) schizophrenia. Given the structural functional heterogeneity of formation, we sought to characterize subfields’ genetic...
Abstract The deviation between chronological age and predicted using brain MRI is a putative marker of overall health. Age prediction based on structural data shows high accuracy in common disorders. However, aging complex heterogenous, both terms individual differences the underlying biological processes. Here, we implemented multimodal model to estimate different combinations cortical area, thickness sub‐cortical volumes, subcortical T1/T2‐weighted ratios, cerebral blood flow (CBF)...
The folding of the human cerebral cortex is a highly genetically regulated process that allows for much larger surface area to fit into cranial vault and optimizes functional organization. Sulcal depth robust yet understudied measure localized folding, previously associated with multiple neurodevelopmental disorders. Here, we report first genome-wide association study sulcal depth. Through multivariate omnibus statistical test (MOSTest) applied vertex-wise measures from 33,748 U.K. Biobank...
Abstract Identifying brain processes involved in the risk and development of mental disorders is a major aim. We recently reported substantial interindividual heterogeneity structural aberrations among patients with schizophrenia bipolar disorder. Estimating normative range voxel‐based morphometry (VBM) data healthy individuals using Gaussian process regression (GPR) enables us to map individual deviations from unseen datasets. Here, we aim replicate our previous results two independent...
A child's socioeconomic environment can shape central aspects of their life, including vulnerability to mental disorders. Negative environmental influences in youth may interfere with the extensive and dynamic brain development occurring at this time. Indeed, there are numerous yet diverging reports associations between parental status (SES) child cortical morphometry. Most these studies have used single metric- or unimodal analyses standard morphometry that downplay probable scenario where...
Abstract Oxytocin is a neuropeptide associated with both psychological and somatic processes like parturition social bonding. Although oxytocin homologs have been identified in many species, the evolutionary timeline of entire signaling gene pathway has yet to be described. Using protein sequence similarity searches, microsynteny, phylostratigraphy, we assigned genes supporting different phylostrata based on when found they likely arose evolution. We show that majority (64%) are ‘modern’....
Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed investigate their neurophysiological effects, using functional MRI, on humans. Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited a double-blind placebo-controlled study. Participants assigned twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo 17). Functional...
Abstract Recent efforts using diffusion tensor imaging (DTI) have documented white matter (WM) alterations in Alzheimer’s disease (AD). The full potential of whole-brain DTI, however, has not been fully exploited as studies focused on individual microstructural indices independently. In patients with AD (n = 79), mild (MCI, n 55) and subjective (SCI, 30) cognitive impairment, we applied linked independent component analysis (LICA) to model inter-subject variability across five complementary...
Abstract The restructuring and optimization of the cerebral cortex from early childhood through adolescence is an essential feature human brain development, underlying immense cognitive improvements. Beyond established morphometric cortical assessments, T1w/T2w ratio quantifies partly separate biological processes, might inform models typical neurocognitive development developmental psychopathology. In present study, we computed vertex‐wise across surface in 621 youths (3–21 years) sampled...
Magnetic field inhomogeneities cause geometric distortions of echo planar images used for functional magnetic resonance imaging (fMRI). To reduce this problem, distortion correction (DC) with map is widely both task and resting-state fMRI (rs-fMRI). Although DC has been reported to improve the quality fMRI, little known about its effects on rs-fMRI. Here, we tested influence field-map rs-fMRI results using two datasets derived from 40 healthy subjects: one (DC+) other without (DC−)....
Abstract Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated loci, including the first linked to midbrain, pons, medulla oblongata volumes, map them 305 genes. In replication 7432 participants most loci show same effect direction are significant at nominal threshold. We detect overlap...
Abstract The response variability to repetitive transcranial magnetic stimulation (rTMS) challenges the effective use of this treatment option in patients with schizophrenia. This may be deciphered by leveraging predictive information structural MRI, clinical, sociodemographic, and genetic data using artificial intelligence. We developed cross-validated rTMS prediction models schizophrenia drawn from multisite RESIS trial. incorporated pre-treatment sMRI, polygenic risk score (PRS) data....
The neuropeptides oxytocin and vasotocin are predominantly produced in the supraoptic paraventricular nuclei of anterior-inferior, anterior-superior tubular-superior hypothalamic subunits. Evidence suggests that signaling play a role both physiology behavior dysfunction these systems may contribute to co-occurrence metabolic psychiatric conditions. genetic pathways, however, underlie connection between physiological behavioral traits yet be clearly delineated. We deployed bivariate mixture...
Abstract The human thalamus is an integrative hub for multiple cortical and subcortical circuits involved in both sensory processing higher cognitive functions. Group-level thalamic volume differences have been reported psychiatric neurological disorders, but previous studies relied on small samples, covered few or only investigated the whole without considering subdivisions. In this multi-site study, we compared nuclei volumes across several disorders (N = 5 094) healthy controls 4 552)....
Abstract Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients . However, little known about volumetric differences at subdivision level these structures. In present study, subfields nuclei were estimated FreeSurfer from 3 T MRI SCZ (SCZ-V, n = 24) without (SCZ-NV, 51) a history severe 90 healthy controls (HC). Volumetric...
Sequalae following stroke represents a significant challenge in current rehabilitation. The location and size of focal lesions are only moderately predictive the diverse cognitive outcome after stroke. One explanation building on recent work brain networks proposes that consequences caused by damages to anatomically distributed supporting cognition rather than specific lesion locations.