A5081010936- Schizophrenia research and treatment
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Psychiatric care and mental health services
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Treatment and Access
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Pharmaceutical studies and practices
- Treatment of Major Depression
- Attention Deficit Hyperactivity Disorder
- Health and Medical Studies
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Cannabis and Cannabinoid Research
- Clinical practice guidelines implementation
Universitätsmedizin Göttingen
2011-2024
University of Göttingen
2014-2024
Klinikum Darmstadt
2014-2024
Medizinische Hochschule Hannover
2023
Medizinisches Zentrum für Seelische Gesundheit
2013-2020
Klinikum im Friedrichshain
2017
Zentrum für Seelische Gesundheit
2013-2016
Heidelberg University
2015
University Hospital Heidelberg
2015
Central Institute of Mental Health
2013-2015
Hippocampal volume is lower than expected in patients with schizophrenia; however, whether this represents a fixed deficit uncertain. Exercise stimulus to hippocampal plasticity.To determine would increase exercise humans and effect be related improved aerobic fitness.Randomized controlled study.Patients attending day hospital program or an outpatient clinic.Male chronic schizophrenia matched healthy subjects.Aerobic training (cycling) playing table football (control group) for period of 3...
These updated guidelines are based on a first edition of the World Federation Societies Biological Psychiatry (WFSBP) for biological treatment schizophrenia published in 2006. For this 2012 revision, all available publications pertaining to were reviewed systematically allow an evidence-based update. provide practice recommendations that clinically and scientifically meaningful. They intended be used by physicians diagnosing treating people suffering from schizophrenia. Based version these...
These guidelines for the biological treatment of schizophrenia were developed by an international Task Force World Federation Societies Biological Psychiatry (WFSBP). The goal during development these was to review systematically all available evidence pertaining schizophrenia, and reach a consensus on series practice recommendations that are clinically scientifically meaningful based evidence. intended use physicians seeing treating people with schizophrenia. data used developing have been...
These updated guidelines are based on the first edition of World Federation Societies Biological Psychiatry (WFSBP) for biological treatment schizophrenia published in years 2005 and 2006. For this 2015 revision, all available publications pertaining to were reviewed systematically allow an evidence-based update. provide practice recommendations which clinically scientifically relevant. They intended be used by physicians diagnosing treating patients with schizophrenia. Based version these a...
Aerobic exercise has been shown to improve symptoms in multiepisode schizophrenia, including cognitive impairments, but results are inconsistent. Therefore, we evaluated the effects of an enriched environment paradigm consisting bicycle ergometer training and add-on computer-assisted remediation (CACR) training. To our knowledge, this is first study evaluate such schizophrenia. Twenty-two schizophrenia patients 22 age- gender-matched healthy controls underwent 3 months endurance (30min,...
Cognitive dysfunction is a common finding in schizophrenia. Nevertheless the specific pattern of neuropsychological impairment schizophrenia compared to other severe mental illnesses has not been intensively studied. Twenty-four patients with belonging different stages disease (11 first-episode patients, 13 multiple episodes), 18 bipolar disorder and 23 healthy control subjects underwent standardized assessment. Statistical analysis covariance (ANCOVA) demonstrated that, subjects, performed...
Cognitive impairments are one of the main contributors to disability and poor long-term outcome in schizophrenia. Proof-of-concept trials indicate that repetitive transcranial magnetic stimulation (rTMS) applied left dorsolateral prefrontal cortex (DLPFC) has potential improve cognitive functioning. We analyzed effects 10-Hz rTMS DLPFC on deficits schizophrenia a large-scale multicenter, sham-controlled study. A total 156 patients with predominant negative symptoms were randomly assigned...
The variability of responses to plasticity-inducing repetitive transcranial magnetic stimulation (rTMS) challenges its successful application in psychiatric care. No objective means currently exists individually predict the patients' response rTMS.We used machine learning develop and validate such tools using pre-treatment structural Magnetic Resonance Images (sMRI) 92 patients with schizophrenia enrolled multisite RESIS trial (http://clinicaltrials.gov, NCT00783120): were randomized either...
Objective: Schizophrenia is a severe mental disorder and many patients are treated in primary care settings. Apart from the pharmacological management of disease-associated symptoms, detection treatment side effects utmost importance clinical practice. The purpose this publication to offer relevant evidence-based recommendations for biological schizophrenia care.Methods: This short practice-oriented summary Parts I–III World Federation Societies Biological Psychiatry (WFSBP) Guidelines...
Abstract Background There is limited knowledge of whether cognitive-behavioral therapy (CBT) or second-generation antipsychotics (SGAs) should be recommended as the first-line treatment in individuals at clinical high risk for psychosis (CHRp). Hypothesis To examine individual arms are superior to placebo and CBT non-inferior SGAs preventing over 12 months treatment. Study Design PREVENT was a blinded, 3-armed, randomized controlled trial comparing management plus aripiprazole (CM + ARI)...
Zusammenfassung: Eine stärkere Orientierung der ärztlichen diagnostisch-therapeutischen Entscheidungsfindung an vorliegenden Leitlinien kann grundsätzlich einen entscheidenden Beitrag zur Erschließung von Optimierungspotenzialen in Psychiatrie und Psychotherapie leisten. Studien verweisen jedoch auf vielfach noch unzureichende Leitlinienkonformität Varianzen Behandlungsqualität. Vor diesem Hintergrund werden zunächst Konzept Methodik Leitlinienentwicklung durch eine Fachgesellschaft am...