A5042211943- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Mindfulness and Compassion Interventions
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Pediatric Pain Management Techniques
- Genetic Associations and Epidemiology
- Digital Mental Health Interventions
- Obsessive-Compulsive Spectrum Disorders
- Genomic variations and chromosomal abnormalities
- Bipolar Disorder and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Perfectionism, Procrastination, Anxiety Studies
- Nicotinic Acetylcholine Receptors Study
- Non-Invasive Vital Sign Monitoring
OsloMet – Oslo Metropolitan University
2018-2025
Faculty of Public Health
2024
Metropolitan University
2024
University of Oslo
2010-2023
Akershus University Hospital
2010-2023
Oxford Health NHS Foundation Trust
2019-2023
Warneford Hospital
2023
University of Oxford
2019-2020
Diakonhjemmet Hospital
2019
Oslo University Hospital
2019
Abstract Previous structural and functional neuroimaging studies have implicated distributed brain regions networks in depression. However, there are no robust imaging biomarkers that specific to depression, which may be due clinical heterogeneity neurobiological complexity. A dimensional approach fusion of modalities yield a more coherent view the neuronal correlates We used linked independent component analysis fuse cortical macrostructure (thickness, area, gray matter density), white...
Depression is associated with reduced executive functioning. Still, we lack a more detailed understanding of the factors explaining this association. Addressing several limitations in previous literature, examine whether poor functioning specific depression symptoms using network approach. The sample consisted currently depressed, previously and never-depressed individuals (n = 289; 67% female; M age 37.4 years). Associations between nine were estimated regularized Gaussian graphical...
Various patterns of structural brain abnormalities have been associated with depression, yet sensitive, specific and clinically predictive correlates proven to be difficult characterize.1 The currently best available empirical evidence on neuroanatomical differences between patients major depression (MDD) healthy controls are two meta-analyses approximately 10 000 individuals.2, 3 These reports show widespread alterations in cortical regions hippocampal volume, but no associations severity...
Abstract Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated loci, including the first linked to midbrain, pons, medulla oblongata volumes, map them 305 genes. In replication 7432 participants most loci show same effect direction are significant at nominal threshold. We detect overlap...
Abstract Background Over-the-counter analgesics (OTCA) such as Paracetamol and Ibuprofen are frequently used by adolescents, the route of administration access at home allows unsupervised use. Psychological distress pain occur simultaneously more common among females than males. There is a dynamic interplay between on-label indications psychological distress, frequent OTCA use or misuse can exacerbate symptoms. No studies have to date provided an overview in larger population-based study....
Attentional bias (AB) is characterized by preferential cognitive and emotional processing of mood-congruent stimuli considered a central mechanism in mood disorders. Considerable research has focused on improving AB measures to enhance mechanistic understanding clinical utility. The present study examines psychometric properties range with multimodal setup. A nonclinical sample 62 women aged 20-30 years completed the facial dot-probe task while behavioral responses (reaction time), eye-gaze...
Abstract The human thalamus is an integrative hub for multiple cortical and subcortical circuits involved in both sensory processing higher cognitive functions. Group-level thalamic volume differences have been reported psychiatric neurological disorders, but previous studies relied on small samples, covered few or only investigated the whole without considering subdivisions. In this multi-site study, we compared nuclei volumes across several disorders (N = 5 094) healthy controls 4 552)....
Dysfunctional metacognitive beliefs ("metacognitions") and executive control are important factors in mental disorders such as depression anxiety, but the relationship between these concepts has not been studied systematically. We examined whether there is an association metacognitions hypothesized that decreased statistically predicts increased levels of metacognitions. Two hundred ninety-nine individuals recruited from general population outpatient psychiatric clinics completed...
Attentional bias modification (ABM) may lead to more adaptive emotion perception and regulation. Understanding the neural basis of these effects greater precision for development future treatments. Task-related functional MRI (fMRI) after ABM training has not been investigated in depression so far. The main aim this randomized controlled trial was explore differences brain activity training, response emotional stimuli.A total 134 people with previous depression, who had treated various...
Using a computational network approach, we reanalyzed data from randomized controlled trial of attention bias modification (ABM) tasks on residual depression symptoms. The main aim was to characterize the symptom-to-symptom changes following ABM. ABM associated with improvements in interest, which turn other Although there were no global strength ABM, comparison symptom change and control group suggests that leads reduction association between anxiety, depressed mood, guilt. Findings suggest...
Following treatment, many depressed patients have significant residual symptoms. However, large randomised controlled trials (RCT) in this population are lacking. When Attention bias modification training (ABM) leads to more positive emotional biases, associated changes clinical symptoms been reported. A broader and transparent picture of the true advantage ABM based on larger stringent requested. The current study evaluates early effect two weeks blinded clinician-rated self-reported...
Abstract Background Studies investigating the long-term effect of attention bias modification (ABM) in clinical samples are lacking. This study investigates 6-months follow-up ABM on depressive symptoms participant with major disorder and without comorbid disorders. Methods We conducted a double-blind randomized sham-controlled trial 101 participants between 19 November 2019, 17 August 2021. Follow-up ended 3 April 2022. Participants were allocated to or sham condition twice daily for 14...
The aim of this study was to explore if the divergent results regarding attentional functions in patients with mood disorders are due selective impairments higher level or more basic and distinctive subcomponents. We compared outpatients current major depressive (MDD; n = 37) MDD comorbid anxiety disorder (MDDA; 24) healthy controls (n 92) on Stroop Attentional Network Test (ANT). data indicate that significant impairment corresponds presence MDDA. MDDA displayed significantly lower...
Numerous genetic and environmental factors contribute to psychiatric disorders other brain disorders. Common risk likely converge on biological pathways regulating the optimization of structure function across lifespan. Here, using structural magnetic resonance imaging machine learning, we estimated gap between age chronological in 36,891 individuals aged 3 96 years, including with different We show that several are associated accentuated aging, strongest effects schizophrenia, multiple...
Alterations in resting state networks (RSNs) are associated with emotional- and attentional control difficulties depressed individuals. Attentional bias modification (ABM) training may lead to more adaptive emotional processing depression, but little is known about the neural underpinnings ABM. In current study a sample of 134 previously individuals were randomized into 14 days computerized ABM- or closely matched placebo regime followed by magnetic resonance imaging (MRI) scan. Using...
Abnormal default mode network (DMN) connectivity has been found in schizophrenia and other psychotic disorders. However, there are limited studies on early onset psychosis (EOP), their results show lack of agreement. Here, we investigated within-network DMN EOP compared to healthy controls (HC), its relationship clinical characteristics. A sample 68 adolescent patients with (mean age 16.53 ± 1.12 [SD] years, females 66%) 95 HC 16.24 1.50 [SD], 60%) from two Scandinavian cohorts underwent...
Background: Impaired cognitive control functions have been demonstrated in both major depression (MDD) and anxiety disorder (A), but few studies systematically examined the impact of MDD with co-morbid A (MDDA), which is main aim this study. Method: We compared patients (MDDA; n = 24) without (n 37) to a group healthy controls (HC; 92) on three subtests from Cambridge Neuropsychological Test Automated Battery; intra–extra dimensional, stop signal task, spatial working memory. These tasks...
Serotoninergic transmission is reliably implicated in inhibitory control processes. The aim of this study was to test the hypothesis if serotonin transporter polymorphisms mediate healthy people. 141 subjects, carefully screened for previous and current psychopathology, were genotyped 5-HTTLPR rs25531 polymorphisms. Inhibitory ascertained with Stop Signal Task (SST) from Cambridge Neuropsychological Test Automated Battery (CANTAB). triallelic gene model, reclassified presented a biallelic...