A5012973610- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Nutrition and Health in Aging
- Family and Patient Care in Intensive Care Units
- Health Systems, Economic Evaluations, Quality of Life
- Ubiquitin and proteasome pathways
- Dysphagia Assessment and Management
- Pharmaceutical Practices and Patient Outcomes
- Child Nutrition and Feeding Issues
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Acute Ischemic Stroke Management
- Health and Wellbeing Research
- Nosocomial Infections in ICU
- Autophagy in Disease and Therapy
- Muscle Physiology and Disorders
- Histone Deacetylase Inhibitors Research
- Patient Dignity and Privacy
- Patient-Provider Communication in Healthcare
- Protein Degradation and Inhibitors
- Intergenerational Family Dynamics and Caregiving
- Sodium Intake and Health
- Phagocytosis and Immune Regulation
- Cardiac Health and Mental Health
- Cardiomyopathy and Myosin Studies
University of Hawaiʻi at Mānoa
2011-2024
University of Oslo
2024
Oslo University Hospital
2024
Hawaii Permanente Medical Group
2016-2024
Epsom and St Helier University Hospitals NHS Trust
2022-2024
St Helier Hospital
2024
Almac (United Kingdom)
2018-2023
James A. Haley Veterans' Hospital
2019-2023
University of KwaZulu-Natal
2023
Harvard University
2020-2022
Exosome-like vesicles containing an active 20 S proteasome core contribute to autoimmunity and vascular allograft inflammation.
The stress status of the apoptotic cell can promote phenotypic changes that have important consequences on immunogenicity dying cell. Autophagy is one biological processes activated in response to a stressful condition. It an mediator intercellular communications, both by regulating unconventional secretion molecules, including interleukin 1β, and extracellular release ATP from early stage cells. Additionally, autophagic components be released caspase-dependent manner serum-starved human...
Abstract It is unclear how the 22q11.2 deletion predisposes to psychiatric disease. To study this, we generated induced pluripotent stem cells from carriers and controls utilized CRISPR/Cas9 introduce heterozygous into a control cell line. Here, show that upon differentiation neural progenitor cells, acted in trans alter abundance of transcripts associated with risk for neurodevelopmental disorders including autism. In excitatory neurons, altered encoded presynaptic factors were genetic...
Phagosomes, by killing and degrading pathogens for antigen presentation, are organelles implicated in key aspects of innate adaptive immunity. Although it has been well established that phagosomes consist membranes from the plasma membrane, endosomes, lysosomes, notion endoplasmic reticulum (ER) membrane could play an important role formation phagosome is debated. However, a method to accurately estimate contribution potential source contaminants proteome lacking. Herein, we have developed...
Approximately, one-third of the world's population is infected with Mycobacterium tuberculosis, causative agent Tuberculosis. Secreted and membrane proteins that interact host play important roles for pathogenicity bacteria are potential drug targets or components vaccines. In this present study, subcellular fractionation in combination enrichment was used to comprehensively analyze M. tuberculosis proteome. The proteome cell wall, membrane, cytosol, lysate, culture filtrate defined a high...
The effect of obesity on late-age survival in women without disease or disability is unknown.
A better understanding of medically centered outcomes, such as physical function, for older women with multiple chronic conditions is a national public health priority.The prevalence multimorbidity (defined having 2 from list 12) and comorbidity coronary disease (CHD) were calculated 33,386 who enrolled in the Women's Health Initiative since 1993-1998 ≥ 80 years old by mid-September 2012. Associations between CHD on RAND-36 function scores estimated using linear regression models.The this...
Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD caused by mutations in several genes with diverse mostly unknown functions. It unclear how dysregulation of these results the relatively selective death nigral dopaminergic neurons (DNs). To address this question, we modeled knocking out PARKIN (PRKN), DJ-1 (PARK7), ATP13A2 (PARK9) independent isogenic human pluripotent stem cell (hPSC) lines. We found increased levels oxidative stress all...
Abstract A key challenge of implementing advance care planning lies in the fact that decisions made require patients and their family members to imagine what clinical picture will look like rather than knowing or experiencing circumstances as they unfold. Even more important is acknowledgment unpredictability a given course. This type situation requires adaptiveness flexibility decision‐making frequently occurs moment(s) triggered by changes health state(s). We describe an alternative...
Background and Purpose— Vitamin D deficiency has been reported to contribute the risk of cardiovascular disease, especially stroke. We examined relationship between dietary vitamin intake 34-year incident Methods— The Honolulu Heart Program is a prospective population-based cohort study 8006 Japanese-American men in Hawaii who were 45 68 years old at baseline examination 1965 1968. Dietary was calculated using Nutritionist IV Version 3 software from 24-hour recall. Subjects with prevalent...
Objectives To examine prestroke lifestyle factors associated with poststroke mortality and recovery in older women. Design Longitudinal prospective cohort study. Setting The W omen's H ealth I nitiative ( WHI , clinical trials observational study), 40 centers the U nited S tates. Participants participants, women aged 50 to 79, who were stroke‐free at baseline (1993/98), incident stroke before 2005. Measurements followed for through 2010. Prestroke characteristics from last examination event....
Muscle fibers lacking dystrophin undergo a long-term alteration of Ca
Objectives To identify potentially modifiable late‐life biological, lifestyle, and sociodemographic factors associated with overall healthy survival to age 85. Design Prospective longitudinal cohort study 21 years of follow‐up (1991–2012). Setting Hawaii Lifespan Study. Participants American men Japanese ancestry (mean 75.7, range 71–82) without baseline major clinical morbidity functional impairments (N = 1,292). Measurements Overall (free from six chronic diseases physical or cognitive...
OBJECTIVES: To study white matter lesions (WMLs) and 5‐year cognitive decline in elderly Japanese‐American men. DESIGN: Longitudinal cohort study. SETTING: Population‐based Honolulu, Hawaii. PARTICIPANTS: men aged 74 to 95 from the Honolulu‐Asia Aging Study (HAAS) who were free of prevalent dementia, underwent a protocol brain MRI scan at fifth HAAS examination (1994–1996), returned for testing 5 years later (N=267). MEASUREMENTS: WMLs dichotomized as present (grade 3–9, 38.2%) or absent...
Macrophages play an important role in innate and adaptive immunity as professional phagocytes capable of internalizing degrading pathogens to derive antigens for presentation T cells. They also produce pro-inflammatory cytokines such tumor necrosis factor alpha (TNF-α) that mediate local systemic responses direct the development immunity. The present work describes use label-free quantitative proteomics profile dynamic changes proteins from resting TNF-α-activated mouse macrophages. These...
OBJECTIVES To examine the use of electronic medical record (EMR) data to ascertain falls and develop a fall risk prediction model in an older population. DESIGN Retrospective longitudinal study using 10 years EMR (2004‐2014). A series 3‐year cohorts included members continuously enrolled for minimum 3 years, requiring 2 pre‐fall (no previous fall) 1‐year period. SETTING Kaiser Permanente Hawaii, ambulatory setting. PARTICIPANTS total 57 678 adults, age 60 older. MEASUREMENTS Initial searches...