A5087563406- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Selenium in Biological Systems
- Nutrition and Health in Aging
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Hormonal and reproductive studies
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Health disparities and outcomes
- Pesticide Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Acute Ischemic Stroke Management
- Physical Activity and Health
- Nuclear Receptors and Signaling
- Cardiac Health and Mental Health
- Menopause: Health Impacts and Treatments
- Coffee research and impacts
Pacific Health Research and Education Institute
2013-2023
VA Pacific Islands Health Care System
2012-2021
University of Hawaii System
2010-2021
University of Hawaiʻi at Mānoa
2011-2020
Kuakini Medical Center
2007-2019
National Institute on Aging
2007-2019
John A. Hartford Foundation
2013-2019
Foundation Center
2013-2019
University of Pennsylvania
2012-2019
Korea University
2019
ContextThe Women's Health Initiative trial of combined estrogen plus progestin was stopped early when overall health risks, including invasive breast cancer, exceeded benefits. Outstanding issues not previously addressed include characteristics cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography.ObjectiveTo determine the relationship use, cancer characteristics, mammography recommendations.Design, Setting,...
Constipation is frequent in PD, although its onset relation to clinical PD has not been well described. Demonstration that constipation can precede could provide important clues understanding disease progression and etiology. The purpose of this report examine the association between frequency bowel movements future risk PD.Information on was collected from 1971 1974 6790 men aged 51 75 years without Honolulu Heart Program. Follow-up for incident occurred over a 24-year period.Ninety-six...
Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it not known whether such can predate the onset of clinical PD in a community-based population. This study examines association future development Honolulu-Asia Aging Study cohort membersOlfaction was assessed from 1991 to 1996 2,267 men aged 71 95 years who were free and dementia at time olfaction testing. Participants followed for up 8 incident RESULTS: In course follow-up, 35 diagnosed (24.6/10,000...
The potential benefit of low-intensity activity in terms longevity among older men has not been clearly documented. We examined the association between walking and mortality a cohort retired who were nonsmokers physically capable participating activities on daily basis.
The course of weight loss associated with dementia is unclear, particularly prior to and around the onset clinical syndrome.To compare natural history change from mid late life in men without life.The Honolulu-Asia Aging Study, a 32-year, prospective, population-based study Japanese American who had been weighed on 6 occasions between 1965 1999 screened for 3 times 1991 1999.Of 1890 (aged 77-98 years), 112 incident were compared 1778 at sixth examination (1997-1999).Weight up including was...
<b>Objective: </b> To determine if excessive daytime sleepiness (EDS) can predate future Parkinson disease (PD). <b>Methods: EDS was assessed in 3,078 men aged 71 to 93 years the Honolulu-Asia Aging Study from 1991 1993. All were free of prevalent PD and dementia. Follow-up for incident based on three repeat neurologic assessments 1994 2001. <b>Results: During course follow-up, 43 developed (19.9/10,000 person-years). After age adjustment, there more than a threefold excess risk with vs...
<h3>Importance</h3> There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute Neurological Disorders Stroke Exploratory Trials in Disease program was established promote discovery potential therapies. <h3>Objective</h3> To determine whether creatine monohydrate more effective than placebo slowing long-term clinical decline participants with disease. <h3>Design, Setting,...
Cardiovascular risk factors often cluster into a metabolic syndrome that may increase the of dementia. The objective present study was to assess long-term association between clustered cardiovascular measured at middle age and dementia in old age. This prospective cohort disease started 1965 extended 1991. subjects were Japanese-American men with an average 52.7+/-4.7 (mean+/-SD) years baseline. Dementia diagnosed 215 men, according international criteria, based on clinical examination,...
A bstract : Clinicopathologic data from 285 autopsies were analyzed. The decedents long‐standing participants in the Honolulu‐Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging. We assessed prevalence at death four primary neuropathologic processes using specific microscopic lesions as indicators. An algorithm was developed to assign each decedent one six subsets, corresponding pathologic dominance by microvascular (14% decedents),...
<b><i>Objective: </i></b> To investigate the relationship between cerebral amyloid angiopathy (CAA), dementia, and cognitive function in an autopsy sample of 211 Japanese-American men from population-based Honolulu–Asia Aging Study. <b><i>Methods: Starting 1991, participants were assessed with Cognitive Abilities Screening Instrument (CASI) diagnosed dementia (including subtype) based on published criteria. At autopsy, neuropathologists blinded to clinical data examined brains for...
To determine whether use of vitamin E and C supplements protects against subsequent development dementia poor cognitive functioning.The Honolulu-Asia Aging Study is a longitudinal study Japanese-American men living in Hawaii. Data for this were obtained from subsample the cohort interviewed 1982, entire mailed questionnaire 1988 prevalence survey 1991 to 1993. The subjects included 3,385 men, age 71 93 years, whose had been ascertained previously. Cognitive performance was assessed with...
Background —Effects of walking on the risk coronary heart disease morbidity and mortality have not been identified in elderly. The purpose this study was to determine whether is associated with a reduced sample elderly men. Methods Results —For study, distance walked (mile/d) examined at baseline examination that occurred from 1991 1993 Honolulu Heart Program. Incident all causes observed over 2- 4-year follow-up period. Subjects followed up were 2678 physically capable men aged 71 93 years....
Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu-Asia Aging Study, aged 74-97 years at death. Quadrants areas within SN determined with a planimeter and neuronal density was expressed as neurons/mm(2) for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body 178 controls neither condition. Mean densities all quadrants significantly lower PD group compared other groups (p = 0.006). This relationship...
To assess the relationship between impaired glucose tolerance and both vascular dementia AD.Diabetes abnormalities of metabolism have been associated with stroke poor cognitive function. In addition, glycoproteins glycosylation postulated to be development neuritic plaques characteristic AD.A historical prospective cohort study Japanese-American men (n = 3,774), who were examined at ages 45 68 (1965 through 1968) again 71 93 (1991 1993). Measurements obtained by clinical home examinations:...
Abstract Neocortical neuritic plaques and neurofibrillary tangles are hallmark neuropathological lesions of dementia. Concomitant cerebrovascular increase dementia severity in patients meeting criteria for Alzheimer's disease contribute to cognitive impairment persons with mild entorhinal Alzheimer lesions. This study investigates whether individuals sparse neocortical experience increased odds crossing the threshold clinical when they have coexistent Dementia examinations were given 3,734...
β-Amyloid (Aβ), a vasoactive protein, and elevated blood pressure (BP) levels are associated with Alzheimer disease (AD) possibly vascular dementia. We investigated the joint association of midlife BP Aβ peptide risk for late-life AD Subjects were 667 Japanese-American men (including 73 brain autopsy), from prospective Honolulu Heart Program/Honolulu Asia Aging Study (1965-2000). Midlife was measured starting in 1971 participants mean age 58 years; specimens collected 1980-1982, assessment...
To examine associations of midlife tofu consumption with brain function and structural changes in late life.The design utilized surviving participants a longitudinal study established 1965 for research on heart disease, stroke, cancer. Information selected foods was available from standardized interviews conducted 1965-1967 1971-1974. A 4-level composite intake index defined "low-low" as fewer than two servings per week no the prior 1971. Men who reported or more at both were "high-high"...
Abstract It is not known if constipation associated with the preclinical phase of Parkinson's disease (PD), often characterized by presence incidental Lewy bodies (ILB). Such an association could provide evidence that early symptom PD. The purpose this report to examine between late‐life bowel movement frequency and ILB. Bowel was assessed from 1991 1993 in 245 men aged 71 93 years Honolulu‐Asia Aging Study who later received postmortem examinations. All were without clinical PD dementia....
Studies of the association high blood pressure (BP) with dementia are not consistent. Understanding long-term trajectories in those who do and develop can help clarify issue. The Honolulu Heart Program/Honolulu-Asia Aging Study followed a cohort Japanese American men for an average 32 years, systolic BP (SBP) diastolic (DBP) measured at 6 examinations assessed final 3. In analysis 1890 completed all exams, 112 diagnosed incident examination were compared 1778 survivors without dementia....
Abstract Olfactory dysfunction is found in early Parkinson's disease (PD) and asymptomatic relatives of PD patients. Incidental Lewy bodies (ILB), the presence brains deceased individuals without a history or dementia during life, are thought to represent presymptomatic stage PD. If olfactory were associated with ILB, this would suggest that deficits may precede clinical The purpose study was determine association late life ILB substantia nigra locus ceruleus. Olfaction assessed 1991–1994...