A5067881298- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Infant Nutrition and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Congenital Heart Disease Studies
- Reproductive System and Pregnancy
- Metabolism and Genetic Disorders
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Cardiovascular Issues in Pregnancy
- Reproductive tract infections research
- Genetic Associations and Epidemiology
- Infant Development and Preterm Care
- Pregnancy-related medical research
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiovascular Conditions and Treatments
- Global Maternal and Child Health
Indiana University Bloomington
2022-2025
University of Iowa
2015-2024
W. M. Keck Foundation
2024
University of California, San Francisco
2020-2024
Indiana University
2023
Cincinnati Children's Hospital Medical Center
2018
March of Dimes
2018
Statens Serum Institut
2018
University of Copenhagen
2018
University of Southern Denmark
2018
There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into best practices in the areas of sequence data generation, analysis, interpretation reporting. The CLARITY Challenge was designed spur convergence diagnosing genetic disease starting from case history data. DNA samples were obtained three families with heritable disorders genomic donated by platform vendors....
Despite evidence that genetic factors contribute to the duration of gestation and risk preterm birth, robust associations with variants have not been identified. We used large data sets included gestational determine possible associations.
Background Racial/ethnic and socioeconomic disparities exist in outcomes for children with congenital heart disease. We sought to determine the influence of race/ethnicity mediating factors on 1‐year live‐born infants hypoplastic left syndrome dextro‐Transposition great arteries. Methods Results The authors performed a population‐based cohort study using California Office Statewide Health Planning Development database. Live‐born without chromosomal anomalies were included. outcome was...
Background Most of the women who smoke before pregnancy continue smoking during pregnancy, and some start to quit after being pregnant, although existing guidelines for recommend that should pregnancy. Findings about timing intensity maternal smoking, especially low-intensity (1–9 cigarettes per day), preterm birth are still inconsistent ambiguous. This study aimed examine association doses first or second trimester with in a large-scale population-based retrospective cohort study. Methods...
Background— Reproductive factors provide an early window into a woman’s coronary heart disease (CHD) risk; however, their contribution to CHD risk stratification is uncertain. Methods and Results— In the Women’s Health Initiative Observational Study, we constructed Cox proportional hazards models for including age, pregnancy status, number of live births, age at menarche, menstrual irregularity, first birth, stillbirths, miscarriages, infertility ≥1 year, cause, breastfeeding. We next added...
Objective To examine the relationship between maternal characteristics, serum biomarkers and preterm birth ( PTB ) by spontaneous medically indicated subtypes. Design Population‐based cohort. Setting California, United States of America . Population From a total population 1 004 039 live singleton births in 2009 2010, 841 665 pregnancies with linked certificate hospital discharge records were included. Methods Characteristics compared for term deliveries subtype using logistic regression...
It is unknown how gestational age (GA) impacts neonatal morbidities in infants with critical congenital heart disease (CCHD). We aim to quantify GA-specific mortality and morbidity CCHD.Cohort study using a database linking birth certificate, infant hospital discharge, readmission, death records, including 22 42 weeks' GA without chromosomal anomalies (2005-2012, 2 988 925 live births). The International Classification of Diseases, Ninth Revision diagnostic procedure codes were used define...
The daily biological clock regulates the timing of sleep and physiological processes that are fundamental importance to human health, performance, well-being. Environmental parameters relevance clocks include (1) fluctuations in light intensity temperature, (2) seasonal changes photoperiod (day length) temperature; these vary dramatically as a function latitude locale. In wide-ranging species other than humans, natural selection has genetically optimized adaptiveness along latitudinal...
To examine recurrent preterm birth and early term in women's initial immediately subsequent pregnancies.This retrospective cohort study included 163,889 women who delivered their first second liveborn singleton neonates between 20 44 weeks of gestation California from 2005 through 2011. Data hospital discharge records certificates were used for analyses. Odds ratios (ORs) 95% confidence intervals (CIs) calculated using logistic regression models adjusted risk factors.Shorter gestational...
BACKGROUND The transfusion of red blood cells (RBCs) with maximum therapeutic efficacy is a major goal in medicine. One the criteria used determining stored RBC quality end‐of‐storage hemolysis. Between donors, wide range hemolysis observed under identical storage conditions. Here, potential mechanism for this investigated. We hypothesize that magnitude heritable trait. Also, we investigated correlations between and metabolites; will establish pathways influencing as future targets genetic...
Introduction: preterm birth is a dire complication of pregnancy that poses huge long-term medical and financial burdens for affected children, their families, the health care system. The aim present study was to identify characteristics associated with births at Lagos University Teaching Hospital (LUTH), Lagos, Nigeria from 2011 2013.
BACKGROUND The development of congenital heart disease (CHD) is multifactorial with genetic and environmental influences. We sought to determine the relationship between socioeconomic factors incidence CHD among live-born infants in California whether maternal comorbidities are causal pathway. METHODS AND RESULTS This was a population-based cohort study (2007-2012). primary outcome having significant CHD. Predictors included status exposure pollutants determined by U.S. Census data. A social...