A5029358934- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Lung Cancer Treatments and Mutations
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Lung Cancer Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Nutritional Studies and Diet
- Breastfeeding Practices and Influences
- Statistical Methods and Bayesian Inference
- Health disparities and outcomes
- Cancer Genomics and Diagnostics
- Regulation of Appetite and Obesity
- Pharmacological Effects and Toxicity Studies
- Cardiac Imaging and Diagnostics
- Retinal Diseases and Treatments
- Infant Development and Preterm Care
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
Fudan University
2011-2025
Zhongshan Hospital
2025
National Health and Family Planning Commission
2023-2025
Seoul National University Hospital
2025
Shanghai Medical College of Fudan University
2013-2024
Chinese PLA General Hospital
1999-2024
Second Affiliated Hospital of Zhejiang University
2024
Aarhus University
2014-2023
Aarhus University Hospital
2017-2023
Central South University
2023
Abstract Objective To evaluate the associations between maternal diabetes diagnosed before or during pregnancy and early onset cardiovascular disease (CVD) in offspring their first four decades of life. Design Population based cohort study. Setting Danish national health registries. Participants All 2 432 000 liveborn children without congenital heart Denmark 1977-2016. Follow-up began at birth continued until time diagnosis CVD, death, emigration, 31 December 2016, whichever came first....
SARS-CoV-2 infection was associated with coronary atherosclerotic plaque progression, as assessed by CT angiography, and worse cardiovascular outcomes.
Purpose PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase (PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we investigated alterations, expression core components PI3K pathway, and evaluated their clinical importance non-small cell cancer (NSCLC). Materials methods Oncogenic mutations/rearrangements PIK3CA, EGFR, KRAS, HER2, BRAF, AKT1 ALK genes were detected tumors from 1117 patients with NSCLC. copy number was examined by...
Purpose To investigate the changes in dry eye symptoms and clinical signs corneal sensitivity after small incision lenticule extraction (SMILE) femtosecond LASIK (femto-LASIK). Design Prospective, non-randomized comparative study. Methods The study included a total of 71 eyes patients; SMILE group comprised 38 patients, femto-LASIK 33 patients. Ocular Surface Disease Index (OSDI), Tear film breakup time (TBUT), Schirmer test without anesthesia (S1T), fluorescein staining, central sensation...
Background Most of the women who smoke before pregnancy continue smoking during pregnancy, and some start to quit after being pregnant, although existing guidelines for recommend that should pregnancy. Findings about timing intensity maternal smoking, especially low-intensity (1–9 cigarettes per day), preterm birth are still inconsistent ambiguous. This study aimed examine association doses first or second trimester with in a large-scale population-based retrospective cohort study. Methods...
Abstract Few data are available on the incidence of deep vein thrombosis (DVT) in critically ill COVID-19 with prophylaxis. This study retrospectively included 88 patients ICU at Jinyintan Hospital Wuhan, China. All underwent compression ultrasonography for identifying DVT. Firth logistic regression was used to examine association DVT sex, age, hypoalbuminemia, D-dimer, and SOFA score. The median (interquartile range [IQR]) age score were 63 (55–71) years old 5 (4–6), respectively. Despite...
Background The prevalence of cardiovascular disease (CVD) has been increasing in children, adolescents, and young adults recent decades. Exposure to adverse intrauterine environment fetal life may contribute the elevated risk early-onset CVD. Many studies have shown that maternal hypertensive disorders pregnancy (HDP) are associated with increased risks congenital heart disease, high blood pressure, BMI, systemic vascular dysfunction offspring. However, empirical evidence on association...
Though gut microbiome disturbance may be involved in the etiology of gestational diabetes mellitus (GDM), data on microbiome's dynamic change during pregnancy and associations with glucose metabolism are still inadequate. In this prospective study comprising 120 pairs GDM patients matched pregnant controls, a decrease diversity microbial species changes community composition advancing gestation found while no such trends observed patients. Multivariable analysis identifies 10 GDM-related...
Transfer learning aims to integrate useful information from multi-source datasets improve the performance of target data. This can be effectively applied in genomics when we learn gene associations a tissue, and data other tissues integrated. However, heavy-tail distribution outliers are common data, which poses challenges effectiveness current transfer approaches. In this paper, study problem under high-dimensional linear models with t-distributed error (Trans-PtLR), estimation prediction...
OBJECTIVE To evaluate associations between gestational diabetes mellitus (GDM) and various incident cardiovascular disease (CVD) end points, considering the effects of mediating role type 2 shared environmental/familial factors. RESEARCH DESIGN AND METHODS This population-based cohort study included 10,02,486 parous women in Denmark during 1978–2016. We used Cox regression to 1) examine GDM with overall type-specific CVDs using full-cohort sibling-matched analysis, 2) quantify impact after...
Abstract Maternal hypertensive disorders during pregnancy (HDP) have been associated with neuropsychiatric problems in offspring. We aim to investigate the associations between specific types of maternal HDP and offspring neurodevelopmental further examine whether timing onset severity would affect these associations. The study population consisted 4,489,044 live-born singletons Denmark 1978–2012 Sweden 1987–2010. was categorized into chronic hypertension, gestational pre-eclampsia;...
<h3>Importance</h3> Maternal diabetes has been suggested as a risk factor for attention-deficit/hyperactivity disorder and autism in offspring, but evidence on its association with the full spectrum of psychiatric disorders remains lacking. <h3>Objective</h3> To investigate associations between maternal diagnosed before or during pregnancy 10 types offspring first 4 decades life. <h3>Design, Setting, Participants</h3> This population-based cohort study used data from several Danish...
To examine the association of maternal hypertensive disorder pregnancy (HDP) with overall and cause specific mortality in offspring from birth to young adulthood.Nationwide population based cohort study.Danish national health registers.All 2 437 718 individuals live born Denmark, 1978-2018, follow-up date until death, emigration, or 31 December 2018, whichever came first.The primary outcome was all mortality. Secondary outcomes were 13 causes death adulthood (age 41 years). Cox regression...
<h3>Importance</h3> Maternal immune activation during pregnancy is associated with increased risks of several mental disorders in offspring childhood, but little known about how maternal autoimmune diseases are health and after childhood. <h3>Objective</h3> To investigate the association between before childbirth risk among up to early adulthood. <h3>Design, Setting, Participants</h3> This population-based nationwide cohort study used data from Danish national registers on singletons born...
Abstract The association between intrauterine growth restriction and cardiovascular disease (CVD) later in life might be confounded by familial factors. We conducted a binational register-based cohort study to assess associations of birth weight for gestational age (GA), proxy restriction, GA with CVD risk early adulthood, before after addressing factors via sibling comparison. included 3,410,334 live nonmalformed singleton births from Sweden (1973–1996) Denmark (1978–1998). During median...
Maternal hypertensive disorders during pregnancy (HDP) have been suggested to contribute the development of offspring cardiovascular disease later in life, but empirical evidence remains inconsistent. This study was aimed assess association maternal overall and type-specific HDPs with diabetes from childhood early adulthood.Using Danish national health registers, a total 2,448,753 individuals born Denmark 1978 2018 were included this study. HDP chronic hypertension, gestational preeclampsia....
Thyroid transcription factor 1 (TTF1) is a master regulator of pulmonary differentiation that downregulated in subset lung adenocarcinoma, which the clinicopathologic characteristics were not fully clarified.One thousand forty-two adenocarcinoma patients who underwent surgery investigated for clinic characteristics, histologic subtyping, and spectrum well-identified driver mutations. TTF1 expression was correlated with these factors survival.Compared positive (TTF1+) patients, 133 negative...
PURPOSE: To investigate objective optical quality and changes in light scatter after femtosecond laser small incision lenticule extraction (SMILE) for moderate to high myopia correction. METHODS: Prospective clinical study of 66 eyes patients (23 males, 43 females) with a mean age 28.67 ± 6.62 years, spherical refraction −6.06 1.57 diopters, cylindrical −0.68 0.46 diopters. Every patient had 3-month follow-up standard SMILE procedure. An analysis system was used measure modulation transfer...
Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence patterns of use ADM from 2006 onward seven different countries was assessed. Research design methods Data sources included individually linked data nationwide health registers Denmark (2006–2016), Finland Iceland (2006–2012), Norway (2006–2015), Sweden state-wide administrative claims New South Wales, Australia (2006–2012) two US...