A5015520219- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Phytoestrogen effects and research
- Cancer Risks and Factors
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- COVID-19 and Mental Health
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- scientometrics and bibliometrics research
- Cytokine Signaling Pathways and Interactions
- Breast Cancer Treatment Studies
- Employment and Welfare Studies
- Sleep and related disorders
- Cancer Cells and Metastasis
- Circadian rhythm and melatonin
- CAR-T cell therapy research
- Air Quality and Health Impacts
- Big Data and Business Intelligence
- Ferroptosis and cancer prognosis
- COVID-19 Pandemic Impacts
- Health, Environment, Cognitive Aging
Chinese University of Hong Kong
2015-2024
Hong Kong Jockey Club
2019-2024
Rockaway Waterfront Alliance
2023
Aarhus University
2022-2023
Prince of Wales Hospital
2022-2023
Aarhus University Hospital
2022-2023
Fudan University
2023
XinHua Hospital
2022
Shanghai Jiao Tong University
2022
Princeton University
2021
Abstract Background Heterogeneity of immune gene expression patterns luminal breast cancer (BC), which is clinically heterogeneous and overall considered as low immunogenic, has not been well studied especially in non-European populations. Here, we aimed at characterizing the profile BC an Asian population associating it with patient characteristics tumor genomic features. Methods We performed profiling adjacent normal tissue 92 patients from Hong Kong using RNA-sequencing data used...
To examine the association of maternal hypertensive disorder pregnancy (HDP) with overall and cause specific mortality in offspring from birth to young adulthood.Nationwide population based cohort study.Danish national health registers.All 2 437 718 individuals live born Denmark, 1978-2018, follow-up date until death, emigration, or 31 December 2018, whichever came first.The primary outcome was all mortality. Secondary outcomes were 13 causes death adulthood (age 41 years). Cox regression...
Maternal hypertensive disorders during pregnancy (HDP) have been suggested to contribute the development of offspring cardiovascular disease later in life, but empirical evidence remains inconsistent. This study was aimed assess association maternal overall and type-specific HDPs with diabetes from childhood early adulthood.Using Danish national health registers, a total 2,448,753 individuals born Denmark 1978 2018 were included this study. HDP chronic hypertension, gestational preeclampsia....
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system that can cause loss motor function and thought to result, in part, from chronic inflammation due antigen-specific T cell immune response. Current treatments suppress without antigen specificity, increasing risks cancer, infection, other long-term side effects. In this study, we show treatment experimental autoimmune encephalomyelitis (EAE), a model MS, by coencapsulating immunodominant peptide...
Abstract Background Individuals with mental health problems have been shown to an increased risk of cardiovascular disorder (CVD), but little is known about the early-onset CVD among those intellectual disability. We aimed investigate association between disability and subsequent CVD, taking into consideration severity neurodevelopmental neurologic comorbidity. Methods This population-based cohort study used individual-level linked data from Danish national registries. Participants were all...
Microblogs are electronic platforms that convey brief communications posted by users. Keyword searches in popular microblogs, like Twitter, reveal fragments of users' knowledge and views on issues climate change. Evaluations change the microblogosphere rare even compared with few studies impacts Web sites blogs perceptions However, extant research focuses more often appraising logic evidence microblog discourse than discovering pathways influence impact. The limiting ‘frames’ imposed...
Importance Sibling death is a highly traumatic event, but empirical evidence on the association of sibling in childhood and early adulthood with subsequent risk incident cardiovascular disease (CVD) remains limited. Objective To evaluate between decades life early-onset CVD. Design, Setting, Participants This population-based cohort study included 2 098 659 individuals born Denmark from 1978 to 2018. Follow-up started at age 1 year or date first sibling’s birth, whichever occurred later, it...
A novel line of research suggests that eating at nighttime may have several metabolic consequences are highly relevant to breast cancer. We investigated the association between habits after 10 p.m. and cancer in Hong Kong women.A hospital-based case-control study was conducted during 2012-2015. total 922 patients with incident (cases) 913 hospital controls were recruited interviewed using a standard questionnaire including information on behavior both daytime nighttime. collected timing,...
Abstract Background This study aims to determine the changes in physical activity and actigraphy-measured rest-activity circadian rhythm among Hong Kong community aged population before during outbreak of COVID-19. Methods is a three repeated measure population-based cross-sectional study. We recruited older men > 60 years periods COVID-19 Kong, i.e., (2 July 2019–8 January 2020), between 2nd 3rd waves (23 June 2020–9 wave (15 September 2020–29 2020). Participants reported detailed...
No risk assessment tool is available for identifying high population of breast cancer (BCa) in Hong Kong. A case–control study including 918 BCa cases and 923 controls was used to develop the model among Kong Chinese women. Each participant received an in-depth interview obtain their lifestyle environmental factors. Least absolute shrinkage selection operator (LASSO) select optimal factors (LASSO-model). score system constructed evaluate cumulative effects selected Bootstrap simulation test...
Abstract Coffee contains caffeine and diterpenes that were associated with decreased breast cancer risk, but results remained inconsistent. The study purpose was to investigate the associations between coffee products risk among Hong Kong Chinese women. We conducted a hospital-based case-control in three public hospitals. 2169 women aged 24–84 years old interviewed using standardized questionnaire questions asking types, cups duration on drinking. used unconditional multivariate logistic...
Growing evidence indicates that adverse prenatal or intrauterine environments might contribute to the development of high refractive error (RE) later in life. However, association maternal hypertensive disorder pregnancy (HDP) with RE offspring during childhood and adolescence remains unknown.To investigate between HDP overall type-specific REs adolescence.This nationwide population-based cohort study included live-born individuals born Denmark from 1978 2018 Danish national health...
( BMJ 2022;379:e072157) A large portion of pregnancies are affected by hypertensive disorders pregnancy (HDP), and they have been associated with poor outcomes during pregnancy, labor, delivery, for children later in life. This study aimed to understand the association between overall specific maternal HDP cause-specific mortality from birth adulthood. Secondary this aim, also investigated whether diabetes education an additional effect on children’s timing onset makes a difference. Primary...
The search for those counsellor'client interaction variables which mediate the level of rapport between participants in counselling sessions remains a major focus, particularly view questions are arising regarding reliability and usefulness to practitioners data from large scale controlled clinical trials specific treatment procedures delivered via standardized manuals. This study examined one therapy variables'verbal response modes'and evaluated its effectiveness upon development Bond...
Age-related DNA methylation is a potential mechanism contributing to breast cancer development. Studies of primarily Caucasian women have identified many CpG sites age-related in non-diseased tissue possibly driving development over time. There paucity studies involving Asian whose ages at onset are usually younger than Caucasians. We the 181 most consistent events across published studies. were measured adjacent normal and tumour an exclusively population previously sites. was found 118...
Abstract Background Few studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted and chronological age, in relation to somatic genomic features paired cancer normal tissue, with less work done non-European populations. In this study, we aimed examine DNAm its associations breast risk factors, subtypes, profiles including mutation copy number alterations other aging markers tissue of Chinese (BC) patients from Hong Kong. Methods We...
Acute compartment syndrome (ACS) is a serious complication of lower-extremity trauma caused by accidents or post-procedure complications. ACS characterized increased pressure within the compartment, resulting in reduced blood flow, tissue hypoxia, and necrosis. Fasciotomies to relieve debridement necrotic comprise primary treatment. My purpose present initial experience using negative wound therapy with instillation dwell time (NPWTi-d)* treat fasciotomy wounds two patients. NPWTi-d provides...
To investigate whether children born to mothers who used carbamazepine during pregnancy had worse academic performance in adolescence.This population-based cohort study included all live-born singletons Denmark between 1996 and 2002 participated the national ninth-grade exit examination (n = 370,859). Those with prescription of antiseizure medications other than were excluded. We examined association utero exposure maternal redeemed 290) offspring, defined by scores Danish mathematics...
Purpose The role of family history to the risk breast cancer was analyzed by incorporating menopausal status in Hong Kong Chinese women, with a particular respect estrogen receptor-positive (ER+) type. Methods Seven hundred and forty seven incident cases 781 hospital controls who had completed information on first-degree relatives (nature father, mother, siblings) were recruited. Odds ratio for calculated unconditional multiple logistic regression, stratified (a surrogate endogenous female...
Relatively few studies investigated the association between rest-activity circadian rhythm and cognitive impairment in population-based study, evidence from Asian populations is sparse. We aimed to examine relationship of actigraphy measured with mild (MCI) or Hong Kong healthy community-dwelling older adults.We recruited 174 adults aged ≥65 years (36 male vs. 138 female) during April-September 2018, followed up them for 12 months. Participants were invited wear wrist 7 days both baseline...
Recent genomic studies suggest that Asian breast cancer (BC) may have distinct somatic features; however, most comparisons of BC features across populations did not account for differences in age, subtype, and sequencing methods. In this study, we analyzed whole-exome (WES) data to characterize
Abstract Background The empirical evidence remains inconclusive for an association between diabetes mellitus (DM) in children and early-onset kidney disease later life, little is known about the effects of DM types (i.e., type 1 [T1DM] 2 [T2DM]) childhood on type-specific diseases. We aimed to evaluate with overall diseases life. Methods population-based matched cohort study included 9356 individuals (T1DM: 8470, T2DM: 886) diagnosed (< 18 years) who were born 1977 2016, 93,560 without...