A5000178592- Nutritional Studies and Diet
- Phytoestrogen effects and research
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Fungal and yeast genetics research
- CRISPR and Genetic Engineering
- Sleep and Work-Related Fatigue
- Coffee research and impacts
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Tea Polyphenols and Effects
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- BRCA gene mutations in cancer
- Protein Kinase Regulation and GTPase Signaling
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Microbial Metabolic Engineering and Bioproduction
Chinese University of Hong Kong
2020
York District Hospital
2019
Alice Ho Miu Ling Nethersole Hospital
2014-2015
The Ohio State University
2009
The Ohio State University Wexner Medical Center
2009
Howard Hughes Medical Institute
2007
Brandeis University
1997-2006
Harvard University
2000-2003
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2000
Abstract Background Heterogeneity of immune gene expression patterns luminal breast cancer (BC), which is clinically heterogeneous and overall considered as low immunogenic, has not been well studied especially in non-European populations. Here, we aimed at characterizing the profile BC an Asian population associating it with patient characteristics tumor genomic features. Methods We performed profiling adjacent normal tissue 92 patients from Hong Kong using RNA-sequencing data used...
Switching of Saccharomyces mating type by replacement sequences at the MAT locus involves a choice between two donors, HML and HMR. α cells inhibit recombination along entire left arm chromosome III, including HML, whereas activate this same region. -dependent activation depends on small, cis -acting DNA sequence designated enhancer (RE), located 17 kb centromere-proximal to HML. A comparison RE interchangeable cerevisiae carlsbergensis defines minimum 244 bp. activity is repressed in...
Mating type (MAT) switching in Saccharomyces cerevisiae is initiated by a double-strand break (DSB) created at MAT HO endonuclease. MATa cells activate the entire left arm of chromosome III; thus preferentially recombines with silent donor HML. In contrast, alpha inactivate arm, including HML, and recombine HMR, 100 kb to right MAT. We present novel competition assay, which DSB can be repaired either or single-strand annealing (SSA) between two URA3 genes flanking With preferred donors,...
A novel line of research suggests that eating at nighttime may have several metabolic consequences are highly relevant to breast cancer. We investigated the association between habits after 10 p.m. and cancer in Hong Kong women.A hospital-based case-control study was conducted during 2012-2015. total 922 patients with incident (cases) 913 hospital controls were recruited interviewed using a standard questionnaire including information on behavior both daytime nighttime. collected timing,...
The majority of the Lafora's disease (LD) is caused by defect in EPM2A gene, including missense and nonsense mutations deletions. These defects mainly occur carbohydrate-binding domain, how these cause neuronal under active investigation. Here, we report that mutant proteins encoded all most deletions tested are unstable, insoluble ubiquitinated, accumulated aggresome-like structures. effect apparent 'gain-of-function' can be corrected co-transfection wild-type cDNA, which consistent with...
No risk assessment tool is available for identifying high population of breast cancer (BCa) in Hong Kong. A case–control study including 918 BCa cases and 923 controls was used to develop the model among Kong Chinese women. Each participant received an in-depth interview obtain their lifestyle environmental factors. Least absolute shrinkage selection operator (LASSO) select optimal factors (LASSO-model). score system constructed evaluate cumulative effects selected Bootstrap simulation test...
Abstract Coffee contains caffeine and diterpenes that were associated with decreased breast cancer risk, but results remained inconsistent. The study purpose was to investigate the associations between coffee products risk among Hong Kong Chinese women. We conducted a hospital-based case-control in three public hospitals. 2169 women aged 24–84 years old interviewed using standardized questionnaire questions asking types, cups duration on drinking. used unconditional multivariate logistic...
Abstract Background Few studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted and chronological age, in relation to somatic genomic features paired cancer normal tissue, with less work done non-European populations. In this study, we aimed examine DNAm its associations breast risk factors, subtypes, profiles including mutation copy number alterations other aging markers tissue of Chinese (BC) patients from Hong Kong. Methods We...
Saccharomyces mating-type switching occurs through a double-strand break-initiated gene conversion event at MAT, using one of two donors located distantly on the same chromosome, HMLα and HMRa. MATa cells preferentially choose HMLα, decision that depends recombination enhancer (RE) controls along left arm chromosome III. We previously showed an fhk1Δ mutation reduces usage in cells, but not to level seen when RE is deleted. now report donor preference also binding Swi4/Swi6 (SBF)...
Age-related DNA methylation is a potential mechanism contributing to breast cancer development. Studies of primarily Caucasian women have identified many CpG sites age-related in non-diseased tissue possibly driving development over time. There paucity studies involving Asian whose ages at onset are usually younger than Caucasians. We the 181 most consistent events across published studies. were measured adjacent normal and tumour an exclusively population previously sites. was found 118...
T cell antigen receptor (TCR)β V(D)J variable region exon assembly is ordered, with Dβ to Jβ rearrangements occurring before joining of Vβs a DJβ complex. Germ-line segments are flanked by recombination signal (RS) sequences, which consist heptamers and nonamers separated spacer 12 (12-RS) or 23 (23-RS) bp. restricted the 12/23 rule; occurs only between gene 12-RSs 23-RSs. Vβ have 23-RSs 12-RSs, based on rule should allow direct joining. However, rearrange complexes not segments, because...
Abstract Aim The prognostic significance of KRAS , NRAS PIK3CA and BRAF mutations was evaluated in C hinese patients with metastatic colorectal cancer (CRC). Method Tumor samples from 183 were retrospectively tested for mutations. Multivariate analysis performed to determine the relationship between mutational status, drug response survival. Result Over 70% received two or more lines chemotherapy, 50% had cetuximab 18% bevacizumab. prevalence 45, 3.2, 5 20%, respectively. For entire cohort,...
Purpose The role of family history to the risk breast cancer was analyzed by incorporating menopausal status in Hong Kong Chinese women, with a particular respect estrogen receptor-positive (ER+) type. Methods Seven hundred and forty seven incident cases 781 hospital controls who had completed information on first-degree relatives (nature father, mother, siblings) were recruited. Odds ratio for calculated unconditional multiple logistic regression, stratified (a surrogate endogenous female...
Recent genomic studies suggest that Asian breast cancer (BC) may have distinct somatic features; however, most comparisons of BC features across populations did not account for differences in age, subtype, and sequencing methods. In this study, we analyzed whole-exome (WES) data to characterize
Breast cancer is the leading cause of morbidity among Shanghai and Hong Kong women, which contributes to 20–25% new female incidents. This study aimed describe temporal trend breast interpret potential effects on observed secular trends. Cancer incident data were obtained from registries. Age-standardized incidence rate was computed by direct method using World population 2000. Average annual percentage change (AAPC) in estimated Joinpoint regression. Age, period cohort assessed a log-linear...
<h3>Objectives</h3> To report updated results on long-term nightshift work and breast cancer risk in Hong Kong women. <h3>Method</h3> This ongoing case-control study involves three hospitals Kong. By 31/03/2013, we've consecutively recruited 443 newly diagnosed cases 335 age-matched controls from the hospital that came from, with a response rate of 90%. We expect to collect 1000 by 31/12/2013. obtained each participant's lifetime occupational history shift work, exposure light-at-night other...
Abstract Preserved food such as cured foods may contain nitrate and nitrite that contribute to the breast cancer development. Evidence on associations between these preserved intakes risk of is sparse. This study aimed examine (i.e., meat, pickled vegetables, canned fruit/vegetables) in Hong Kong Chinese women. A total 1,307 cases 1,050 age-matched controls were recruited from three hospitals during November 2011 through January 2018. We used a standardized questionnaire collect information...
Abstract Disease heterogeneity of immune gene expression patterns luminal breast cancer (BC) has not been well studied. We performed profiling tumor and adjacent normal tissue in 92 Asian BC patients identified three distinct subtypes. Tumors one subtype exhibited signs T-cell activation, lower ESR1/ESR2 ratio higher checkpoint genes, nonsynonymous mutation burden, APOBEC -signature mutations, increasing body mass index compared to other tumors. a second were characterized by increased...