A5103036079- Photonic and Optical Devices
- Plasmonic and Surface Plasmon Research
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Advanced Fiber Optic Sensors
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Optical Coatings and Gratings
- Effects and risks of endocrine disrupting chemicals
- Sleep and Work-Related Fatigue
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Potato Plant Research
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Microfluidic and Bio-sensing Technologies
- Alcohol Consumption and Health Effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Phase-change materials and chalcogenides
- Infective Endocarditis Diagnosis and Management
- Workplace Health and Well-being
- Microplastics and Plastic Pollution
- Liver Disease and Transplantation
Chinese University of Hong Kong
2008-2023
Hong Kong Jockey Club
2017
City University of Hong Kong
2003
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach–Zehnder interferometer design is presented. The novel feature of new use a Wollaston prism through which phase quantities p and s polarizations are interrogated simultaneously. Since SPR affects only polarization, signal due to polarization can be used as reference. Consequently, differential between two allows us eliminate all common-path noise while keeping change caused by effect. Experimental results obtained...
Abstract Background Heterogeneity of immune gene expression patterns luminal breast cancer (BC), which is clinically heterogeneous and overall considered as low immunogenic, has not been well studied especially in non-European populations. Here, we aimed at characterizing the profile BC an Asian population associating it with patient characteristics tumor genomic features. Methods We performed profiling adjacent normal tissue 92 patients from Hong Kong using RNA-sequencing data used...
Phase detection has been utilized to enhance the sensitivity of surface plasmon resonance (SPR) sensors for a long time. However, an inherent drawback phase sensitive SPR are their limited dynamic range, which greatly hindered wide applications such sensors. In this Letter, design combining and angular interrogation proposed provide sensor with both high range. As result, resolution 2.2×10−7 RIU range over 0.06 achieved simultaneously. An added advantage is flexibility adjustment.
The aim of the study is to explore longitudinal association dietary acrylamide exposure with cognitive performance in Chinese elderly. analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. Ms. OS Hong Kong. Dietary intake assessed by food frequency questionnaires data local contamination, derived from first Kong Total Diet Study. Global function Cantonese version Mini-Mental State Exam (MMSE) at baseline 4th year follow-up....
As in all RNA viruses, influenza viruses change and mutate constantly because their polymerase has no proofreading ability. This poses a serious threat to public health nowadays. In addition, traditional pathogen-based detection methods may not be able report an infection from unknown type or subtype of virus if its nucleotide sequence is known. Because these factors, targeting host microRNA signatures alternative classify infections distinguish types pathogens as microRNAs are produced...
Objectives Accumulated evidence implies that night shift work may trigger liver dysfunction. Non-alcoholic fatty (NAFL) is suggested to be a necessary mediator in this process. This study aimed examine the relationship between and elevated level of alanine transaminase (e-ALT) workers investigate potential mediation effect NAFL. Methods included all male from baseline survey cohort workers. Information on demographics, lifestyle lifetime working schedule was collected by face-to-face...
We present a biosensor design based on capturing the two-dimenstional (2D) phase image of surface plasmon resonance (SPR). This 2D SPR imaging technique may enable parallel label-free detection multiple analytes and is compatible with microarray chip platform. system uses our previously reported differential measurement approach, in which maps obtained from signal (P) reference (S) polarizations are compared pixel by pixel. greatly improves resolution as subtraction step can eliminate...
Ho Pui HoThe Chinese University of Hong KongDepartment Electronic EngineeringShatin, N.T.Hong Kong, ChinaW. W. WongS. Y. WuCity Engineering83 Tat Chee Avenue, KowloonHong ChinaAbstract. We present a multilayered optical storage disk design basedon the use frequency up-conversion in rare earth. This offersthe potential increased density. In our experiment, athree-layered sample is prepared by stacking three sections thinglass slide on which stripes
What we believe to be a novel two-dimensional spectral surface plasmon resonance imaging technique determining pressure distribution in elastohydrodynamic lubricant films is presented. This makes use of the characteristics associated with (SPR) effect, and it provides more information refractive index mapping than conventional contrast SPR imaging. Two-dimensional demonstrated applied highly pressurized liquid trapped inside an lubrication (EHL) dimple. The hydrostatic EHL dimple causes...
The numerical simulation of a novel white-light interferometric surface plasmon resonance (WLISPR) sensor with high sensitivity and wide dynamic range is presented. It perceived that the use broadband polychromatic source might effectively enable detection scheme at same time achieving comparable phase to conventional laser-based (SPR) configuration. As different from single-point spectrally resolved approach using spectrometer, purposed 2D imaging interferometer can be integrated into...
Loop-mediated isothermal amplification (LAMP) is a rapid (within an hour) and sensitive method to amplify DNA at one temperature. It has high potential be used as biosensor detect pathogens LAMP does not require thermal cycles DNA. On the other hand, surface plasmon resonance (SPR) highly optical system for label-free biomolecules detection. With these advantages, we tried combine SPR gene of Panton-Valentine leukocidin toxin (pvl) Methicillin-resistance S. aureus (MRSA). Our preliminary...
Objectives Experimental studies suggested that bisphenol A (BPA) exposure increased the risk of metabolic syndrome (MetS) through mechanism insulin resistance. All previous epidemiological BPA and MetS were cross-sectional studies, their findings mixed. This study aims to provide further evidence on association between urinary using a prospective cohort in China. Methods The population was from Shenzhen Night shift workers’ cohort. total 1227 male workers recruited baseline survey 2013 then...
A novel design of multi-pass phase-sensitive surface plasmon resonance (SPR) biosensor is presented. The system based on differential phase interrogation scheme incorporated to the Michelson or Fabry-Perot interferometer configuration. An intrinsic amplification effect achieved by placing SPR sensor head in signal arm so that interrogating optical beam traverses multiple times. Experimental results obtained from antibody-antigen and protein-DNA binding reaction using both configurations...
Bacterial infection is a disaster leading to high fatal rate in intensive caring unit. Rapid profiling of infectious bacteria necessary for applying the correct medication. Current gold standard using plate inoculation inaccurate, time-consuming and labour-intensive. Therefore we have developed molecular diagnostic approach target marker DNA rapid profiling. A micro-fluidic platform lab-on-a-disc (LOAD) has been adopted because one simple spinning action can provide highly controllable...