A5087429893- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Algal biology and biofuel production
- Bone health and osteoporosis research
- Pelvic and Acetabular Injuries
- Bone Metabolism and Diseases
- Structural Load-Bearing Analysis
- Catalytic Alkyne Reactions
- Bone health and treatments
- Cervical and Thoracic Myelopathy
- Advanced Wireless Communication Technologies
- Cyclopropane Reaction Mechanisms
- Structural Behavior of Reinforced Concrete
- Concrete Corrosion and Durability
- Neuroscience and Neuropharmacology Research
- Catalytic C–H Functionalization Methods
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Impact of Light on Environment and Health
- Arsenic contamination and mitigation
- Renal and related cancers
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
Nanjing University of Posts and Telecommunications
2022-2024
Liaoning Ocean and Fisheries Research Institute
2021-2024
Ministry of Agriculture and Rural Affairs
2024
Northeastern University
2004-2024
Weatherford College
2023
Fujian Normal University
2023
Anhui Jianzhu University
2020-2023
The First Affiliated Hospital, Sun Yat-sen University
2009-2022
Shanghai Jiao Tong University
2016-2022
Sun Yat-sen University
2009-2022
// Bailing Chen 1 , Miaomiao Yu Qingshan Chang Yongju Lu Chitra Thakur Danjun Ma Zhengping Yi Fei Department of Pharmaceutical Sciences, Eugene Applebaum College Pharmacy, Wayne State University, 259 Mack Avenue, Detroit, MI, USA Correspondence: Chen, email: Keywords : mdig, H19, demethylation, prognosis Received :July 2, 2013 Accepted August 8, Published 10, Abstract Mineral dust-induced gene (mdig) had been linked to the development human lung cancers associated with environmental exposure...
The molecular mechanisms by which arsenic (As3+) causes human cancers remain to be fully elucidated. Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit polycomb-repressive complexes (PRC2) that promotes trimethylation lysine 27 histone H3, leading altered expression tumor suppressors or oncogenes. In present study, we determined effect As3+ on EZH2 phosphorylation and signaling pathways important for As3+-induced in bronchial epithelial cell line BEAS-2B. involvement kinases was...
The addition of alkynylmagnesium chlorides to N-tert-butanesulfinyl imines proceeded with a remarkably high diastereoselectivity (dr > 13:1, mostly diastereopure), and general scope both reaction partners. dr translated into simplified purification higher optical purity for the synthesis wide array chiral alpha-branched amines. alkyne functionality also provides multitude opportunities further synthetic transformations. short asymmetric (+)-angustureine 7 (-)-cuspareine 10 was realized use...
// Kai Wu 1 , Qingshan Chang Yongju Lu Ping Qiu Bailing Chen Chitra Thakur Jiaying Sun Lingzhi Li Anjaneyulu Kowluru Fei Department of Pharmaceutical Sciences, Eugene Applebaum College Pharmacy and Health Wayne State University, Detroit, MI, USA Correspondence: Chen, email: Keywords : Gefitinib, EGFR, STAT3, Akt recovery Received September 22, 2013 Accepted November Published 24, Abstract Hyperactivation Epidermal Growth Factor Receptor (EGFR) tyrosine kinase is prevalent in human lung...
Abstract BACKGROUND The differentiation between intracranial atherosclerotic stenosis (ICAS) and embolism as the immediate cause of acute ischemic stroke requiring endovascular therapy is important but challenging. In cases ICAS, we often observe a phenomenon call microcatheter “first-pass effect,” which temporary blood flow through occluded artery when angiographic initially advanced site total occlusion immediately retrieved proximally. OBJECTIVE To evaluate whether this first-pass effect...
Abstract Separating oil and water remains a serious challenge because various oil/water mixtures are generated in large quantities by industrial processes, unexpected accidents, daily life. Various systems containing materials with specific structures wettabilities have been investigated as possible solutions to this issue. As sustainable biological material, wood its derivatives many advantageous properties for practical applications. The present review mainly focuses on recent progress...
Abstract: Metabolic dysfunction associated steatohepatitis (MASH) is a progressive liver disease with related complications and death. Kylo0603 novel agonist for the thyroid hormone receptor β (THR-β) that has been developed by merging structures of three acetylgalactosamine (GalNAc)modified ASPGR ligands triiodothyronine (T3) analog. This unique design allows both THR-β activation targeted delivery to hepato-cytes, significantly reducing risk adversed effects increased systemic hormone-like...
In Brief Study Design. A prospective clinical trial was conducted. Objective. To compare the and radiologic late results of monosegmental transpedicular fixation versus short-segment pedicle instrumentation (SSPI) in management thoracolumbar burst fractures evaluate efficacy fixation. Summary Background Data. SSPI (1 level above 1 below fracture level) are accepted by many surgeons as an technique for treatment fractures. preserve more motion segments, some authors have advocated (MSPI). The...
// Qingshan Chang 1 , Bailing Chen Chitra Thakur Yongju Lu Fei Department of Pharmaceutical Sciences, Eugene Applebaum College Pharmacy and Health Wayne State University, Detroit, MI, USA Correspondence: Chen, email: Keywords : cancer stem cells, arsenic, self-renewal, sub-lethal stress, JNK Received January 24, 2014 Accepted :February 18, Published February 19, Abstract In the present report, we demonstrate that stress induced by consecutive exposure to 0.25 µM arsenic (As 3+ ) for six...
A new method was developed to synthesize N2-alkyl-substituted 1,2,3-triazole through N-iodosuccinimide (NIS) mediated iodofuctionalization reaction of the alkene group with bi-, mono-, and unsubstituted NH-1,2,3-triazoles. The favored N-1 type hydrogen bond between iodonium ion intermediate supposed be generated, which gave desired N2-alkyl triazole a high N2-selectivity.
The aim of the study is to explore longitudinal association dietary acrylamide exposure with cognitive performance in Chinese elderly. analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. Ms. OS Hong Kong. Dietary intake assessed by food frequency questionnaires data local contamination, derived from first Kong Total Diet Study. Global function Cantonese version Mini-Mental State Exam (MMSE) at baseline 4th year follow-up....
We previously reported that expression of an environmentally induced gene, mineral dust-induced gene (mdig), predicts overall survival in breast cancer patients. In the present report, we further demonstrate differential roles mdig between earlier- and later-stage cancers. noncancerous breast, is a proliferation factor for cell growth motility. cancer, however, higher levels negatively regulate migration invasion cells. Assessment global DNA methylation, chromatin accessibility H3K9me3...
The potential effects of intermittent parathyroid hormone (1-34) [PTH (1-34)] administration on bone formation have previously been investigated. A number studies suggested that the cyclic adenosine monophosphate/protein kinase (cAMP/PKA) pathway is associated with PTH-induced osteogenic differentiation. However, precise signaling pathways and molecular mechanism by which PTH induces differentiation mesenchymal stromal cells (BMSCs) remain elusive. purpose present study was to investigate...
Synergistic-to-additive antileukemic interactions of piperlongumine (PL) and HDAC inhibitor (HDACi) SAHA (Vorinostat) provide a compelling rationale to construct PL-HDACi hybrids, such as 1-58, which recapitulated the synergism between parental compounds in high-risk chemoresistant AML cells. Both PL HDACi components, either combination or hybrid molecules, are essential for inducing significant DNA damage apoptosis. Introducing C2-chloro substituent 1-58 yielded 3-35 with increased...
The aim of this study is to explore the association dietary patterns with depression, perceived stress, and self-esteem among postmenopausal Chinese women.A cross-sectional was conducted 906 participants who attended screening visits for two soy trials. Dietary data were collected using a validated food frequency questionnaire containing 85 items. Principal component factor analysis used derive based on 11 groups. Psychological factors assessed by Center Epidemiologic Studies Depression...