A5032423805- Ion Channels and Receptors
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Hydrogen's biological and therapeutic effects
- Circular RNAs in diseases
- Bone and Joint Diseases
- Multiple Myeloma Research and Treatments
- Ion channel regulation and function
- Spinal Fractures and Fixation Techniques
- Polysaccharides and Plant Cell Walls
- Mesenchymal stem cell research
- Dental Erosion and Treatment
- RNA Research and Splicing
- Scoliosis diagnosis and treatment
- Exercise and Physiological Responses
- Cancer-related molecular mechanisms research
- Thermoelastic and Magnetoelastic Phenomena
- Employment and Welfare Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
Southern Medical University
2023-2025
Nanfang Hospital
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2022
Sun Yat-sen University
2020-2022
Wuhan University
2019-2022
Guangzhou Medical University
2022
Guangzhou First People's Hospital
2022
Key Laboratory of Guangdong Province
2022
Zhongnan Hospital of Wuhan University
2022
University of Electronic Science and Technology of China
2022
The transient receptor potential vanilloid-1 (TRPV1) ion channel is essential for sensation of thermal and chemical pain. TRPV1 activation accompanied by Ca2+-dependent desensitization; acute desensitization reflects rapid reduction in activity during stimulation, whereas tachyphylaxis denotes the diminution responses to repetitive stimulation. Acute has been attributed conformational changes channel; however, mechanisms underlying establishment remain be defined. Here, we report that degree...
Background: Osteoporotic vertebral compression fracture (OVCF) is a common disease in elderly population, which could cause serious back pain and has substantial impact on patients’ health-related quality of life (HRQoL). The aim this study was to identify the effect Teriparatide as conservative treatment reducing pain, improving for postmenopausal women with osteoporotic fractures.Methods: In 12-month, retrospective study, 112 OVCFs were assigned group (20 µg Teriparatide, subcutaneous,...
Abstract Background With the increase in life expectancy, a large number of patients with osteoporosis (OP) are undergoing spine surgery, which may adversely affect surgical success rate. The prevalence OP varies different regions, and no data available that represent among Chinese over 50 years age who surgery. It was first multicenter study to assess these patients. Aiming obtain comprehensive data, this combined bone mineral density (BMD) measurements visual radiography assessment (VRA)...
Background. Circular RNAs (circRNAs) contribute to the regulation of many diseases. However, little is known about role circRNAs in development glucocorticoid-induced osteoporosis (GIOP). The present study aimed at systematically characterizing circRNA expression profiles GIOP and predict potential functions associated regulatory networks. Methods. A small animal model was developed Sprague-Dawley rats given daily intraperitoneal doses synthetic glucocorticoid dexamethasone. Micro-CT bone...
Objective: Postmenopausal osteoporosis (PMOP), a chronic systemic metabolic disease prevalent in middle-aged and elderly women, heavily relies on bone mineral density (BMD) measurement as the diagnostic indicator. In this study, we investigated serum microRNAs (miRNAs) possible screening tool for PMOP. Methods: This investigation recruited 83 eligible participants from 795 community-dwelling postmenopausal women between June 2020 August 2021. The miRNA expression profiles of PMOP patients...
While serum bone turnover markers (BTMs) and mineral density (BMD) have been confirmed as useable risk assessment tools for postmenopausal osteoporosis, the associations between BTMs BMD changes are still ambiguous. The aim of this study was to explore underlying in women.Between January 2015 October 2020, 135 women were retrospectively enrolled. They divided into two groups according lumbar spine (LS) 1-4 change (1 y T-score minus baseline T-score, Group 1 [n = 36] < 0 2 99] ≥ 0)....
Transient receptor potential vanilloid 2 (TRPV2) is a multimodal ion channel implicated in diverse physiopathological processes. Its important involvement immune responses has been suggested such as the macrophages’ phagocytosis process. However, endogenous signaling cascades controlling gating of TRPV2 remain to be understood. Here, we report that enhancing tyrosine phosphorylation remarkably alters chemical and thermal sensitivities endogenously expressed rat bone marrow-derived...
While the prognosis of multiple myeloma (MM) has significantly improved over last decade because new treatment options, it remains incurable. Aetiological explanations and biological targets based on genomics may provide additional help for rational disease intervention.Three microarray datasets associated with MM were downloaded from Gene Expression Omnibus (GEO) database. GSE125364 GSE39754 used as training set, GSE13591 was verification set. The differentially expressed genes (DEGs)...
Prevention of fragility fractures is one the public health priorities worldwide, whilst incidence osteoporotic vertebral compression (OVCF) continues to rise and lacks corresponding accurate prediction model. This study aimed screen potential causes risk factors for primary non-traumatic (NTOVCF) in elderly by characterizing a patient population with NTOVCF comparing it patients.Between January 2013 2022, 208 patients unequivocal evidence bone manifested as painful were enrolled, compared...
Transient receptor potential vanilloid subtype 2 (TRPV2) channel is a polymodal regulating neuronal development, cardiac function, immunity and oncogenesis. The activity of TRPV2 regulated by the molecular interactions in subplasmalemmel signaling complex. Here yeast two-hybrid screening cDNA library mouse dorsal root ganglia (DRG) patch clamp electrophysiology, we identified that flotillin-1, lipid raft-associated protein, interacts with regulates its function. interaction between...
Clear aligners have become one of the most important tools in orthodontic treatment. However, over a lengthy period treatment, enamel demineralization or even dental caries could be susceptible for occurrence. Therefore, early diagnosis has been widely investigated. Nevertheless, reasons including bulky monitoring equipment and complexity operation, few techniques reported to date possessed clinical utility. The combination flexible electronics electrochemical sensing technology presented...
Abstract Background The synthetic chemical 1,4-dioxane is used as industrial solvent, food, and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments humans, but molecular mechanisms underlying its effects on animals were not previously known. Results Here, we report that potentiates capsaicin-sensitive transient receptor potential (TRP) channel TRPV1, thereby causing hyperalgesia mouse model. This effect was abolished by...
Transient receptor potential vanilloid 1 (TRPV1) channel is a multimodal that responsible for nociceptive, thermal, and mechanical sensations. However, which biomolecular partners specifically interact with TRPV1 remains to be elucidated. Here, we used cDNA library screening of genes from mouse dorsal root ganglia combined patch-clamp electrophysiology identify the voltage-gated potassium auxiliary subunit Kvβ1 physically interacting regulating its function. The interaction was validated in...
Interstitial fluid (ISF) is considered an underutilized source of biomarkers for disease diagnosis and monitoring. However, biomacromolecular markers cannot be enriched in ISF due to the restriction capillary walls, which limits wide use analysis. Here, integrated micro-extracting system (MES) that includes a multimicrochannel microneedles (MMNs) array bilayer suction cup presented. The coupled with negative pressure (NP) realizes high-efficiency extraction in-situ recruitment minimally...
Abstract Transient receptor potential vanilloid 2 (TRPV2) is a multimodal ion channel widely regulating central and peripheral functions. Its important involvement in immune responses has been suggested such as the macrophages’ phagocytosis process. However, endogenous signaling cascades controlling gating of TRPV2 remain to be understood. Here, we report that enhancing tyrosine phosphorylation remarkably alters chemical thermal sensitivities endogenously expressed rat bone marrow-derived...
Therapy of very severe osteoporotic compression fractures (VSOVCF) has been a growing challenge for spine surgeons. Opinions vary regarding the optimal surgical procedure treatment VSOVCF and which internal fixation method is more effective still under debate, research on this topic lacking. This retrospective study was conducted to compare efficacy safety various pedicle screw methods treating VSOVCF.This single-center comparative between January 2015 September 2020. Two hundred one...
In this theoretical study, we investigate the propagation of Love waves in a piezoelectric layered structure. The substrate structure is functionally graded material (FGM) which parameters vary along thickness and bounded domain. Both variable substitution power series technique, are shown to have good convergence high precision, employed for asymptotic analytical derivations governing equation wave. influence gradient coefficient FGM on dispersion curves, electro-mechanical coupling factor,...