A5100718441- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Chemotherapy-induced organ toxicity mitigation
- Metabolism and Genetic Disorders
- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Genetic diversity and population structure
- Microbial Metabolism and Applications
- Immune Cell Function and Interaction
- Ear and Head Tumors
- Cancer therapeutics and mechanisms
- Genetic factors in colorectal cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Pregnancy-related medical research
- Hair Growth and Disorders
- Lung Cancer Treatments and Mutations
- Vibrio bacteria research studies
- PI3K/AKT/mTOR signaling in cancer
- Identification and Quantification in Food
- Ferroptosis and cancer prognosis
Stomatology Hospital
2025
Sun Yat-sen University
2025
Sichuan University
2018-2024
West China Hospital of Sichuan University
2018-2024
Logistics University of People's Armed Police Force
2023
University of Pennsylvania
2023
The University of Texas MD Anderson Cancer Center
2020-2022
Ningbo University
2022
Second People’s Hospital of Huai’an
2019-2021
Xuzhou Medical College
2019-2021
Acute kidney injury (AKI) is a serious clinical complication with high morbidity and mortality rates. Despite substantial progress in understanding the mechanism of AKI, no effective therapy available for treatment or prevention. We previously found that G protein-coupled receptor (GPCR) family member free fatty acid 4 (FFAR4) agonist TUG891 alleviated dysfunction tubular AKI mice. However, versatile role FFAR4 has not been well characterized. In study, expression was abnormally decreased...
Abstract Diabetic nephropathy (DN) is a severe end‐stage kidney disease developed from diabetes mellitus. The involvement of circular RNAs (circRNAs) in modulating DN pathogenesis has been implied, but underlying mechanism still lacking. In this study, we demonstrated that the expression circ_0080425 correlated with progression, and exerted positive effect on cell proliferation fibrosis mesangial cells. Further assessment suggested function as sponge harboring miR‐24‐3p. Moreover, miR‐24‐3p...
Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. In this study, we employed kidney-specific expression quantitative traits and single-nuclear open chromatin analysis to show that genetic variants linked dysfunction on chromosome 20 target acyl-CoA synthetase short-chain family 2 (ACSS2). By generating ACSS2 knock-out mice, demonstrated their protection from fibrosis in multiple disease...
// Kai Wu 1 , Qingshan Chang Yongju Lu Ping Qiu Bailing Chen Chitra Thakur Jiaying Sun Lingzhi Li Anjaneyulu Kowluru Fei Department of Pharmaceutical Sciences, Eugene Applebaum College Pharmacy and Health Wayne State University, Detroit, MI, USA Correspondence: Chen, email: Keywords : Gefitinib, EGFR, STAT3, Akt recovery Received September 22, 2013 Accepted November Published 24, Abstract Hyperactivation Epidermal Growth Factor Receptor (EGFR) tyrosine kinase is prevalent in human lung...
Traumatic brain injury (TBI) is associated with trauma-related death. In this study, we evaluated differences in the expression of plasma microRNAs (miRNAs) patients different degrees TBI, and explored potential miRNAs for use as diagnostic TBI biomarkers. The miRNA microarray results showed upregulation 65, 33, 16 downregulation 29, 27, 6 mild, moderate, severe respectively, compared healthy controls. Thirteen (seven upregulated six downregulated) were found to be present all groups. Seven...
Abstract Although inhibition of neprilysin (NEP) might be a therapeutic strategy with the potential to improve outcome chronic kidney disease (CKD), versatile function NEP its mechanism remains obscure in fibrosis. In study, we found that was abnormally increased tubular epithelial cells CKD patients, as well unilateral ureteral obstruction and adenine diet‐induced mice. Treatment United States Food Drug Administration‐approved inhibitor Sacubitrilat (LBQ657) could alleviate ferroptosis,...
Abstract Histone deacetylases 6 (HDAC6) has been reported to be involved in the pathogenesis of cisplatin-induced acute kidney injury (AKI). Selective inhibition HDAC6 might a potential treatment for AKI. In our previous study, highly selective inhibitor (HDAC6i) 23BB effectively protected against rhabdomyolysis-induced AKI with good safety. However, whether possessed favorable renoprotection and mechanisms remained unknown. cisplatin-injected mice developed severe symptom as indicated by...
The complete mitochondrial genome of Chionodraco hamatus was obtained, which 17 457 bp in length. This consists 13 protein-coding genes, 22 transfer RNA 2 ribosomal genes and a putative control region. Of the 37 28 were encoded by heavy strand, while 9 light strand. Overall base composition mitogenome is estimated to be 26.38% for A, 17.44% G, 26.00% T, 30.18% C, respectively, with slight A + T bias (52.38%). phylogenetic analysis based on concatenated suggested that C. as sister species...
有机硅化合物已被广泛应用于有机合成、生物医药和材料科学等领域.一直以来,发展简洁高效的C—Si键构筑方法学备受科学家们的广泛关注.过渡金属催化卡宾对Si—H键的插入反应是形成C—Si键的重要方法之一,不仅具有操作简便、反应条件温和及原子经济性高等优点,还可以通过手性配体的调控高对映选择性地实现手性有机硅烷化合物的合成.近年来,该领域取得了飞速的发展,涌现了许多新的卡宾前体和金属催化体系.按照过渡金属元素所处族的分类,分五个部分介绍了自2012年以来有关铁、铜、锌、钌、铑、钯、银、铱和金过渡金属卡宾对Si—H键插入反应的研究进展.
Introduction. To investigate the function of miR-190a-3p on proliferation and migration glioma. Methods. Twenty glioma samples 6 normal brain tissue were collected. Normal human glial cell line HEB lines used for experiments. We then TargetScan to predict target genes miR-190a-3p. Dual-luciferase reporter assay was also validate. Results. Combined with dual-luciferase experiment, we finally verified that YOD1 aim, it low-expressed in Besides, a series mechanism experiments proved negatively...
Renal fibrosis is the principal process underlying progression of chronic kidney disease to end-stage renal disease. It a relatively uniform response involving glomerulosclerosis, tubulointerstitial and changes in vasculature. A considerable number studies have confirmed that inducible nitric oxide synthase (iNOS) was highly expressed interstitial overexpression iNOS played negative role progression. In our previous study, SKLB023 as novel small-molecule inhibitor iNOS, blocked joint...
Numerous flavonoid Diels-Alder-type natural products have been isolated and received great attention from the synthetic community. Herein, we reported a catalytic strategy for an asymmetric Diels-Alder reaction of 2'-hydroxychalcone with range diene substrates using chiral ligand-boron Lewis acid complex. This method enables convenient synthesis wide cyclohexene skeletons in excellent yields moderate to good enantioselectivities, which is critical prepare product congeners further biological studies.
Pancreatic cancer is a highly aggressive malignant disease having very limited therapeutic options that ultimately results in its poor prognosis. It still elusive on the etiology and tumorigenic mechanisms of pancreatic cancer. In present report, we provide evidence showing involvement mineral dust-induced gene (mdig) pathogenesis prognosis Using immunohistochemistry approach human tissue microarray, found differential expression mdig adenocarcinoma normal pancreas. Based staining...
Abstract Background and Aims Dysregulated lipid metabolism cellular senescence intricately interact in the context of acute kidney injury (AKI). Fatty acid-binding protein 4 (FABP4), a critical enzyme regulating metabolism, potentially induces cell through lipotoxicity AKI. However, specific mechanisms remain unclear. Method We established an ischemia-reperfusion-induced AKI (IRI-AKI) model C57 mice quantified localized FABP4 expression renal tissues using Western blotting (WB), qPCR,...
Abstract Background and Aims Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. Method Human renal tissue, fixed formaldehyde, embedded paraffin, was selected from the files of Service Pathology West China Hospital, Sichuan University.ACSS2 knockout mice tubular specific knock out ACSS2 C57BL/6N background wild-type littermates (WT) were used to induce FAN UUO model or...
Keloid is a fibroproliferative disorder in the skin, which manifested with extensive deposition of collagen and extracellular matrix. Its etiology remains mystery its recurrence rate high despite combinative treatment regimens. Current hypotheses pathogenesis centered on role inflammatory processes as well immune infiltration microenvironment. However, there are lot discrepancies when it comes to verification certain well-recognized pathways involved dysfunctional fibroblast. Further...
Abstract Background and Aims Cellular senescence is associated with renal disease progression. Accelerated tubular cell promotes the pathogenesis of fibrosis no matter caused by natural aging or disease. However, underlying mechanism unknown. Method Proteomic analysis kidney from 20-week mice was used to find potential target protein which acyl-CoA synthetase medium chain family member 3 (Acsm3). After finding it, two Acsm3 inhibitor (4-Methylsalicylic acid 2-hydroxyoctanoic acid) were...