A5101868045- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Gut microbiota and health
- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Lymphoma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Systemic Sclerosis and Related Diseases
- Musculoskeletal pain and rehabilitation
- Helicobacter pylori-related gastroenterology studies
- Rheumatoid Arthritis Research and Therapies
- Brain Tumor Detection and Classification
- Renal and related cancers
- Spine and Intervertebral Disc Pathology
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Monoclonal and Polyclonal Antibodies Research
- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Epigenetics and DNA Methylation
- Abdominal Trauma and Injuries
- Renal and Vascular Pathologies
- Anesthesia and Pain Management
University of Pennsylvania
2023-2025
Kyung Hee University
2007-2024
Ewha Womans University
2024
James Cook University Hospital
2024
Zero to Three
2023
Ajou University
2021-2022
National Institute of Diabetes and Digestive and Kidney Diseases
2021
ProQuest (United States)
2021
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation newly signals on common variants European ancestry populations the power population diversity for further discoveries. We defined genotype effects allele-specific gene expression...
Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. In this study, we employed kidney-specific expression quantitative traits and single-nuclear open chromatin analysis to show that genetic variants linked dysfunction on chromosome 20 target acyl-CoA synthetase short-chain family 2 (ACSS2). By generating ACSS2 knock-out mice, demonstrated their protection from fibrosis in multiple disease...
Objective Genome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant pathogenesis but showing a large fraction of missing heritability. As continuous effort, we conducted GWAS Korean case–control population. Methods We newly generated genome-wide variant data two independent cohorts comprising 4068 cases and 36 487 controls, followed by whole-genome imputation meta-analysis the disease results cohorts. By integrating...
Systemic lupus erythematosus (SLE) is a highly heritable complex disorder with heterogeneous clinical manifestations. In this study, we aimed to identify the genetic risk load using and serological manifestations in SLE patients.We genotyped total of 1,655 Korean patients (n = 1,243 as discovery set n 412 replication set) customized genome-wide single-nucleotide polymorphism (SNP) array, KoreanChip. A weighted score (wGRS) for an individual was calculated from 112 well-validated non-HLA SNPs...
Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise underlying 110 SLE that were in latest East Asian GWAS meta-analysis.
Convolutional neural networks (CNNs) have been used widely to predict biological brain age based on magnetic resonance (MR) images. However, CNNs focus mainly spatially local features and their aggregates barely the connective information between distant regions. To overcome this issue, we propose a novel multi-hop graph attention (MGA) module that exploits both global connections of image when combined with CNNs. After insertion convolutional layers, MGA first converts convolution-derived...
Objective CD4 + T cells have been suggested as the most disease-relevant cell type in rheumatoid arthritis (RA) which RA-risk non-coding variants exhibit allele-specific effects on regulation of RA-driving genes. This study aimed to understand RA-specific signatures using multi-omics data, interpreting inter-omics relationships shaping RA transcriptomic landscape. Methods We profiled genome-wide variants, gene expression and DNA methylation from 82 patients with 40 healthy controls...
The high prevalence of comorbid mental disorders (CMDs) in patients with inflammatory bowel disease (IBD) is well-documented. This study delves into the intricate CMD-IBD relationship through comprehensive analyses using human variants, gut microbiome, and anxiety/depression estimates from a cohort 507 IBD 75 controls. Notably, IBD, especially those CMD, exhibited lower diversity than We identified 106 differentially abundant taxa (DATs) compared to controls 21 DATs distinguishing...
We aimed to evaluate the usefulness of neutrophil-to-lymphocyte (N/L) and platelet (N/LP) ratios in predicting late mortality patients with trauma who underwent emergency surgery.We retrospectively evaluated older than 19 y surgery at our level I center. Blood count-based (N/L N/LP days 1, 3, 7 hospitalization) scores were analyzed. Statistical analysis was performed using univariable logistic regression receiver operating curves.A total 209 evaluated. day 7, N/L Trauma Injury Severity...
INTRODUCTION: The family history of inflammatory bowel disease (IBD) has been strongly associated with risk developing IBD. This study aimed to identify the host genetic and gut microbial signatures in familial METHODS: Genetic analyses using genome-wide single nucleotide polymorphism genotyping whole exome sequencing were performed calculate weighted scores from known IBD-associated common variants rare deleterious protein-altering specific patients IBD 8 Korean families that each included...
Abstract We hypothesized that deep neuromuscular blockade (NMB) with low-pressure pneumoperitoneum (PP) would improve respiratory mechanics and reduce biotrauma compared to moderate NMB high-pressure PP in a steep Trendelenburg position. Seventy-four women undergoing robotic gynecologic surgery were randomly assigned two equal groups. Moderate group was maintained train of four count 1–2 at 12 mmHg. Deep post-tetanic 8 Inflammatory cytokines measured baseline, the end PP, 24 h after surgery....
To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with presence of lupus nephritis (LN).We retrospectively divided patients systemic erythematosus (SLE, n=1,078) into biopsy-proven LN (n=507) non-LN groups (non-LN, n=571) Baseline features, serologic markers, wGRS collected The was calculated from 112 non-human leukocyte antigen (non-HLA) loci HLA-DRβ1 amino acid haplotypes for SLE Associations among wGRS, identified.In multivariate analysis,...
: Endoscopic epidural neuroplasty (EEN) facilitates adhesiolysis through direct epiduroscopic visualization, offering more precise neural decompression than that exhibited by percutaneous (PEN). We aimed to compare the effects of EEN and PEN for 6 months after treatment with lower back radicular pain in patients.
Systemic lupus erythematosus (SLE) causes irreversible damage to organ systems. Recently, evidence has been obtained for subphenotypes of SLE. This study aimed identify clusters and compare the associated clinical manifestations, SLE disease activity, mortality, genetic risk scores (GRS).The was conducted on Hanyang BAE cohort. Patients with duration <5 years were excluded minimize confounding effects duration. They grouped into 3 based Lupus International Collaborating Clinics Damage Index...
Objective HLA association fine‐mapping studies have shown the effects of missense variants in HLA–DRB1 on rheumatoid arthritis (RA) susceptibility, prognosis, and autoantibody production. However, phenotypic expression changes remain poorly understood. Therefore, we investigated allele‐specific its effect an HLA–DRβ1 structure–associated trait RA. Methods We quantified each 3‐field classic allele 48 Korean RA patients with anti–citrullinated protein antibodies (ACPAs) 319 healthy European...
Genome-wide association studies (GWAS) have identified over 800 loci associated with kidney function, yet the specific genes, variants, and pathways involved remain elusive. By integrating function GWAS human expression methylation quantitative trait analyses, we Ten-Eleven Translocation (TET) DNA demethylase 2 (TET2) as a novel disease risk gene. Utilizing single-cell chromatin accessibility CRISPR-based genome editing, highlight variants that influence TET2 in proximal tubule cells....
Cognitive dysfunction, a significant complication of type 2 diabetes mellitus (T2DM), can potentially manifest even from the early stages disease. Despite evidence global brain atrophy and related cognitive dysfunction in early-stage T2DM patients, specific regions vulnerable to these changes have not yet been identified. The study enrolled patients with less than five years' duration without chronic complications (T2DM group, n=100) demographically similar healthy controls (control n=50)....
<h3>Background</h3> In Parkinson's Disease (PD), over half of the patients develop psychotic symptoms course their disease (1). PD Psychosis is associated with an increased risk nursing home admission, and mortality when compared to without psychosis (2). Clozapine recommended by NICE as antipsychotic that does not worsen motor for PDP. <h3>Results</h3> South Tees Movement disorder service, we looked at 33 have been prescribed clozapine from 2016 until November 2023. 19 had died since...