Laurent F. Thomas
A5081901040- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Psoriasis: Treatment and Pathogenesis
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Migraine and Headache Studies
- Osteoarthritis Treatment and Mechanisms
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Folate and B Vitamins Research
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Pelvic floor disorders treatments
- Neuroscience of respiration and sleep
- Musculoskeletal pain and rehabilitation
- BRCA gene mutations in cancer
- Suicide and Self-Harm Studies
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
- Bioinformatics and Genomic Networks
Norwegian University of Science and Technology
2012-2025
St Olav's University Hospital
2020-2024
Molecular Oncology (United States)
2023
Hudson Institute
2021
John Wiley & Sons (United States)
2021
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Aix-Marseille Université
2019-2020
Hôtel-Dieu de Lyon
2013
Institut Gustave Roussy
2011
Centre National de la Recherche Scientifique
2011
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants 11 osteoarthritis phenotypes, 52 of which have not been the disease before. We report thumb spine differences in genetic effects between weight-bearing non-weight-bearing joints. sex-specific early age-at-onset loci. integrate functional genomics data from...
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation newly signals on common variants European ancestry populations the power population diversity for further discoveries. We defined genotype effects allele-specific gene expression...
Motivation: Circular RNAs (circRNAs) are an abundant class of highly stable that can affect gene regulation by binding and preventing microRNAs (miRNAs) from regulating their messenger RNA (mRNA) targets. Mammals have thousands circRNAs with predicted miRNA sites, but only two been verified as being actual sponges. As it is unclear whether these sites functional, we investigated seed within human under selective pressure. Results: Using SNP data the 1000 Genomes Project, found a significant...
MicroRNAs regulate diverse cellular processes and play an integral role in cancer pathogenesis. Genomic variation within miRNA target sites may therefore be important sources for genetic differences risk. To investigate this possibility, we mapped HapMap single nucleotide polymorphisms (SNP) to putative recognition genes dysregulated estrogen receptor-stratified breast tumors used local linkage disequilibrium patterns identify high-ranking SNPs the Cancer Genetic Markers of Susceptibility...
Significance Statement Uremic toxicity may play a role in the elevated risk of developing cognitive impairment observed patients with CKD. Some uremic toxins, such as indoxyl sulfate, are agonists transcription factor aryl hydrocarbon receptor (AhR). The authors found that three models CKD rats is correlated serum levels sulfate well blood-brain barrier disruption detected by SPECT/CT imaging. Using AhR −/− knockout mice, described for first time sulfate–induced activation responsible...
Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction AAA heritability.We performed genome-wide association study in the Million Veteran Program testing ≈18 million DNA sequence variants with (7642 cases and 172 controls) veterans European ancestry independent replication up to 4972 99 858 controls. We then used mendelian...
This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related CKD in European and East Asian ancestries using Mendelian randomization.
Polygenic risk scores (PRS) measure genetic disease susceptibility by combining effects across the genome. For coronary artery (CAD), type 2 diabetes (T2D), and breast prostate cancer, we performed cross-ancestry evaluation of genome-wide PRSs in six biobanks Europe, United States, Asia. We studied transferability these highly polygenic, global ancestries, within European populations with different health-care systems, local population substructures a isolate. All four had similar accuracy...
Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report genome-wide association study of back using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) intervertebral disc (IDD) (58,854 922,958 controls). We identify 41 variants at 33 loci. The most significant (OR
Combination of age at diagnosis, stage and MYCN amplification stratifies neuroblastoma into low-risk high-risk. We aimed to establish whether a microRNA (miRNA) signature could be associated with prognosis in both groups. Microarray expression profiling human miRNAs quantitative reverse-transcriptase PCR selected were performed on preliminary cohort 13 patients. Results validated an independent 214 The relationship between miRNA the overall or disease-free survival was analysed total 227...
Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine less certain although glutamatergic serotonergic neurotransmission are implicated both. A shared genetic basis to mental disorders has been suggested but previous studies have reported weak non-significant correlations five risk loci. Using the largest samples date novel statistical tools, we aimed determine extent which migraine's polygenic architecture...
Abstract Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to not fully explained variation at robustly risk loci. To move towards saturation map susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls 109 distinct loci, 45 that been previously reported. These include variants loci in which...