Steven J. Micheletti
A5040780932- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Parkinson's Disease Mechanisms and Treatments
- Amphibian and Reptile Biology
- Race, Genetics, and Society
- Genomics and Phylogenetic Studies
- Neurological diseases and metabolism
- Animal Behavior and Reproduction
- Genetics and Neurodevelopmental Disorders
- Fish Ecology and Management Studies
- Forensic and Genetic Research
- Wildlife Ecology and Conservation
- Genomic variations and chromosomal abnormalities
- Cognitive Abilities and Testing
- Neuroscience and Music Perception
- Lysosomal Storage Disorders Research
- Music and Audio Processing
- Bioinformatics and Genomic Networks
- Cell Adhesion Molecules Research
- Obesity, Physical Activity, Diet
- Biochemical Analysis and Sensing Techniques
- Nutrition, Genetics, and Disease
- Nonmelanoma Skin Cancer Studies
- Genomics and Rare Diseases
23andMe (United States)
2020-2024
Columbia River Inter-Tribal Fish Commission
2017-2023
University of Idaho
2018-2023
University of British Columbia
2023
University of Exeter
2023
Washington State University
2013-2021
San Francisco State University
2012
University of California, Davis
2010
Abstract Reading and writing are crucial life skills but roughly one in ten children affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study 51,800 adults self-reporting diagnosis 1,087,070 controls identified 42 independent significant loci: 15 genes linked cognitive ability/educational attainment, 27 new potentially more specific...
Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies performed in just one population at a time. Here we large-scale multi-ancestry meta-analysis of with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals European, East Asian, Latin American African ancestry. In meta-analysis, 78 significant loci, 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2,...
Abstract Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency act prematurely and associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) eight impulsive personality traits from Barratt Impulsiveness Scale short UPPS-P Impulsive Personality ( N = 123,509–133,517 23andMe research participants European ancestry), measure Drug Experimentation 130,684). Because these GWAS...
According to historical records of transatlantic slavery, traders forcibly deported an estimated 12.5 million people from ports along the Atlantic coastline Africa between 16th and 19th centuries, with global impacts reaching present day, more than a century half after slavery's abolition. Such have fueled broad understanding forced migration Americas yet remain underexplored in concert genetic data. Here, we analyzed genotype array data 50,281 research participants, which—combined shipping...
High-density genome-wide sequencing increases the likelihood of discovering genes major effect and genomic structural variation in organisms. While there is an increasing availability reference genomes across broad taxa, greatest limitation to whole-genome multiple individuals continues be costs associated with sequencing. To alleviate excessive costs, pooling similar phenotypes homogenized DNA (Pool-Seq) can achieve high genome coverage, but at loss individual genotypes. Although Pool-Seq...
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom alpha-synucleinopathies and defines a more severe subtype. The genetic background RBD its underlying mechanisms are not well understood. Here, we perform genome-wide association study RBD, identifying five risk loci near SNCA, GBA, TMEM175, INPP5F, SCARB2. Expression analyses highlight SNCA-AS1 potentially SCARB2 differential expression in different brain regions with...
Although many rare variants have been reportedly associated with Parkinson's disease (PD), not replicated or failed to replicate. Here, we conduct a large-scale replication of PD variants. We assessed total 27,590 cases, 6701 proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, AMP-PD. Based on well-known genes, 834 interest were selected the ClinVar annotated 23andMe dataset. performed meta-analysis using summary statistics all studies. The resulted in five...
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists substantial gap across populations. We propose MUSSEL, method for ancestry-specific polygenic prediction that borrows information in summary statistics from genome-wide association studies (GWASs) multiple ancestry groups via Bayesian hierarchical modeling ensemble learning. In our simulation data analyses four distinct studies, totaling 5.7 million...
Abstract The LRRK2 G2019S variant is the most common cause of monogenic Parkinson’s disease (PD); however, questions remain regarding penetrance, clinical phenotype and natural history carriers. We performed a 3.5-year prospective longitudinal online study in large number 1286 genotyped carriers 109 154 controls, with without PD, recruited from 23andMe Research Cohort. collected self-reported motor non-motor symptoms every 6 months, as well demographics, family histories environmental risk...
A broad portfolio of phenotypic diversity in natural organisms can buffer against exploitation and increase species persistence disturbed ecosystems. The study genomic variation that accounts for ecological evolutionary adaptation represent a powerful approach to extend understanding nature. Here we present chromosome-level reference genome assembly Chinook salmon ( Oncorhynchus tshawytscha ; 2.36 Gb) enabled association mapping life-history traits this species. Whole-genome re-sequencing...
Heterogeneous landscapes and fluctuating environmental conditions can affect species dispersal, population genetics, genetic structure, yet understanding how biotic abiotic factors dynamics in a environment is critical for management. We evaluated spatio-temporal habitat connectivity influences dispersal structure of boreal chorus frogs (Pseudacris maculata) using landscape genetics approach. developed gravity models to assess the contribution various observed distance as measure functional...
Disparity in the timing of biological events occurs across a variety systems, yet understanding genetic basis underlying diverse phenologies remains limited. Variation maturation steelhead trout, which has been associated with greb1L, an oestrogen target gene. Previous techniques that identified this gene only accounted for about 0.5-2.0% genome and solely investigated coastal populations, leaving uncertainty on trait its prevalence larger geographic scale.We used three-tiered approach to...
Abstract Basal cell carcinoma and squamous are the most common skin cancers, have genetic overlap with melanoma, pigmentation traits, autoimmune diseases, blood biochemistry biomarkers. In this multi-trait analysis of over 300,000 participants from Europe, Australia United States, we reveal 78 risk loci for basal (19 previously unknown replicated) 69 (15 replicated). The implicated in cancer development progression (e.g. CDKL1 ), TPCN2 cardiometabolic FADS2 immune-regulatory pathways innate...
Abstract The central–marginal hypothesis ( CMH ) predicts that population size, genetic diversity and connectivity are highest at the core decrease near edges of species' geographic distributions. We provide a test using three replicated core‐to‐edge transects encompass nearly entire range endemic streamside salamander Ambystoma barbouri ). confirmed mapped distribution was most suitable habitat ecological niche modelling ENM via estimates effective sizes. As predicted by , we found...
Abstract Organisms typically show evidence of adaptation to features within their local environment. However, many species undergo long‐distance dispersal or migration across larger geographic regions that consist highly heterogeneous habitats. Therefore, selection may influence adaptive genetic variation associated with landscape at residing sites and along routes in migratory species. We tested for genomic natal spawning paths the ocean anadromous steelhead trout ( Oncorhynchus mykiss)...
Abstract There is currently a dearth of accessible whole genome sequencing (WGS) data for individuals residing in the Americas with Sub-Saharan African ancestry. We generated at intermediate (15×) coverage 2,294 large amounts ancestry, predominantly Atlantic admixed varying European and American performed extensive comparisons variant callers, phasing algorithms, filtration on these to construct high quality imputation panel containing from 2,269 unrelated individuals. With exception TOPMed...
Few African Americans have been able to trace family lineages back ancestors who died before the 1870 United States Census, first in which all Black people were listed by name. We analyzed 27 individuals from Maryland’s Catoctin Furnace American Cemetery (1774–1850), identifying 41,799 genetic relatives among consenting research participants 23andMe, Inc.’s database. One of highest concentrations close is Maryland, suggesting that descendants remain area. find many derived ancestry Wolof or...
Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant condition that predisposes to emphysema, cirrhosis, panniculitis, and vasculitis. Underrecognition has prompted efforts enhance early detection testing of at-risk individuals. Direct-to-consumer (DTC) genetic represents additional method detection.
To further our understanding of the genetics musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGS