A5087957892- Social and Educational Sciences
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Frailty in Older Adults
- Diet and metabolism studies
- Nutrition and Health in Aging
- Cognitive Abilities and Testing
- Health Systems, Economic Evaluations, Quality of Life
- Bioinformatics and Genomic Networks
- Genetics and Neurodevelopmental Disorders
- Intergenerational Family Dynamics and Caregiving
- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Family Support in Illness
- Health disparities and outcomes
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Early Childhood Education and Development
- Air Quality and Health Impacts
- Genomics and Rare Diseases
Karolinska Institutet
2015-2025
Institute for Biomedicine
2024
University of Gothenburg
2022-2024
Jönköping University
2018-2023
University of Southern California
2017
University of California, Riverside
2017
Karolinska University Hospital
1988-1990
Linköping University Hospital
1982
Combinations of gentamicin with cefotaxime, moxalactam, and ceftazidime were tested against 43 bacterial strains, most them blood isolates. With an interaction index less than or equal to 0.5 as borderline, synergism was demonstrated 30 40% the strains by fractional inhibitory concentration 50 70% bactericidal index. The reproducibility within +/- 0.2 for two-thirds 40 repetitive assays 0.4 all these assays. Similar results obtained when netilmicin substituted gentamicin. killing curve...
Background: Population-based health registers are potential assets in epidemiological research; however, the quality of case ascertainment is crucial. Objective: To compare dementia, from National Patient Register (NPR) and Cause Death (CDR) with dementia diagnoses six Swedish population based studies. Methods: Sensitivity, specificity, positive predictive value (PPV) identification NPR CDR were estimated by individual record linkage studies ( n = 19,035). Time to detection was using data on...
Rationale: Observational studies have found shorter leukocyte telomere length (TL) to be a risk factor for coronary heart disease (CHD), and recently the association was suggested causal. However, relationship between TL common metabolic factors CHD is not well understood. Whether these could explain pathways from warrants further attention. Objective: To examine whether mediate causal pathway short increased of using network Mendelian randomization design. Methods Results: Summary...
This study aimed to investigate the association between shift work and incident dementia in two population-based cohorts from Swedish Twin Registry (STR). The STR-1973 sample included 13,283 participants born 1926–1943 who received a mailed questionnaire 1973 that asked about status (ever/never) duration (years) of employment. Screening Across Lifespan (SALT) 41,199 1900–1958 participated telephone interview 1998–2002 night duration. Dementia diagnoses came patient registers. Cox...
Frailty index (FI) is a well-established predictor of all-cause mortality, but less known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are also understudied association between FI mortality. Furthermore, population impact frailty remains understudied.We estimated predictive value taking into account factors, tested associations time-dependent. We assessed proportion deaths that attributable to increased levels frailty. analyzed...
Abstract The heritability of Alzheimer’s disease estimated from twin studies is greater than the derived genome-based studies, for reasons that remain unclear. We apply both approaches to same sample, considering polygenic risk scores and models, provide insight into role measured genetic variants quantify uncaptured risk. A population-based association study was conducted between 1986 2016 first incorporate biometrical models disease. sample included 1586 twins drawn Swedish Twin Registry...
A total of 188 strains representing 11 species gram-negative bacteria were examined for the ability to interact with human plasminogen. Highly purified plasminogen was labeled 125I, and its uptake by different bacterial measured. All 14 Haemophilus influenzae all 13 Branhamella catarrhalis tested positive respect uptake. Also, eight belonging family Enterobacteriaceae tested, those, Proteus mirabilis demonstrated most substantial uptake, 28 39 taking up more than 10% Ten Pseudomonas...
Frailty is a complex manifestation of aging and associated with increased risk mortality poor health outcomes. However, younger individuals (under 65 years) are less-studied in this respect. Also, the relationship between frailty cause-specific community settings understudied. We used 42-item Rockwood-based index (FI) Swedish Adoption/Twin Study Aging (n=1477; 623 men, 854 women; aged 29-95 analyzed its association all-cause up to 30-years follow-up. Deaths due cardiovascular disease (CVD),...
Summary Late-onset Alzheimer’s disease is a prevalent age-related polygenic that accounts for 50-70% of dementia cases 1 . caused by combination many genetic variants with small effect sizes and environmental influences. Currently, only fraction the underlying have been identified 2,3 Here we show increased sample allowed identification seven novel loci contributing to disease. We highlighted eight potentially causal genes where gene expression changes are likely explain association. Human...
Abstract Body mass index (BMI) is associated with cognitive abilities, but the nature of relationship remains largely unexplored. We aimed to investigate bidirectional from midlife through late-life, while considering sex differences and genetic predisposition higher BMI. used data 23,892 individuals European ancestry Health Retirement Study, longitudinal on BMI three established indices: mental status, episodic memory, their sum, called total cognition. To dynamic between we applied dual...
Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into would highly valuable. Environmental and lifestyle factors largely modulate risk may influence pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental affect multiple tissues of body, we hypothesized disease-associated methylation signatures are detectable in peripheral blood...
Abstract Late onset Alzheimer’s disease (AD) is the most common form of dementia with more than 35 million people affected worldwide, and no curative treatment available. AD highly heritable recent genome-wide meta-analyses have identified over 20 genomic loci associated AD, yet only explaining a small proportion genetic variance indicating that undiscovered exist. Here, we performed largest association study clinically diagnosed AD-by-proxy (71,880 cases, 383,378 controls). status based on...
frailty shows an upward trajectory with age, and higher levels increase the risk of mortality. However, it is less known whether shape trajectories differs by age at death or rate change in associated mortality.to assess population to analyse current level index (FI) i.e. most recent measurement person-specific more predictive mortality.3,689 individuals from three population-based cohorts up 15 repeated measurements Rockwood were analysed. The FI assessed stratifying sample into four...
Abstract Background/Objectives Insulin-like growth factor-binding protein (IGFBP)-1 is a marker of insulin resistance. Lower IGFBP-1 associated with increased adiposity. The aims this study were to determine whether and its ligand, IGF-I, are weight waist measurements across mid-life old age, predict survival. Subjects/Methods Swedish Adoption/Twin Study Aging (SATSA) includes extensive in-person testing same-sex twins over 30-year period. dataset for which baseline fasting ( n = 512; 251...
Abstract Background While a high body mass index (BMI) in midlife is associated with higher risk of dementia, BMI late-life may be lower risk. This study combined genetic designs longitudinal data to achieve better understanding this paradox. Methods We used from 22,156 individuals the Swedish Twin Registry (STR) and 25,698 Health Retirement Study (HRS). The STR sample had information about early adulthood through late-life, HRS age 50 late-life. Survival analysis was applied investigate...
Abstract Age is a dominant risk factor for some of the most common neurological diseases. Biological ageing encompasses interindividual variation in rate and can be calculated from clinical biomarkers or DNA methylation data amongst other approaches. Here, we tested hypothesis that biological age greater than one's chronological affects future diagnosis development abnormal signs on examination. We analysed Swedish Adoption/Twin Study Aging (SATSA): cohort with 3175 assessments 802...
Abstract Background DNA methylation-derived epigenetic clocks and frailty are well-established biological age measures capturing different aging processes. However, whether they dynamically linked to each other across chronological remains poorly understood. Methods This analysis included 1 309 repeated measurements in 524 individuals aged 50–90 years from the Swedish Adoption/Twin Study of Aging. Frailty was measured using a validated 42-item index (FI). Five were calculated, including 4...
Diabetes mellitus type 2 (T2D) is associated with accelerated biological aging and the increased risk of onset other age-related diseases. Epigenetic changes in DNA methylation levels have been found to serve as reliable biomarkers for aging. This study explores relationship between various epigenetic diabetes using longitudinal data. Data from Swedish Adoption/Twin Study Aging (SATSA) was collected 1984 2014 included 536 individuals at least one measurement. The following were employed:...