A5010427465- Cervical Cancer and HPV Research
- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Reproductive tract infections research
- Endometrial and Cervical Cancer Treatments
- Genital Health and Disease
- Cancer Risks and Factors
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Gut microbiota and health
- Bioinformatics and Genomic Networks
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Adolescent and Pediatric Healthcare
- Intergenerational Family Dynamics and Caregiving
- Nutritional Studies and Diet
- Dementia and Cognitive Impairment Research
- Adolescent Sexual and Reproductive Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
Karolinska Institutet
2016-2025
Karolinska Institutet Innovations (Sweden)
2022
Uppsala University
2015-2021
Instituto de Investigación Biosanitaria de Granada
2021
MRC Unit for Lifelong Health and Ageing
2021
University College London
2021
National Institute on Aging
2021
National Institutes of Health
2021
Queen Mary University of London
2021
Vitenparken
2021
Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment status, by using sequence analysis immunohistochemistry, incomplete assessors functional effects. We posited that transcriptional fingerprint is a definitive downstream indicator function. Herein, we analyzed transcript profiles 251 p53-sequenced primary breast tumors identified clinically embedded 32-gene expression signature distinguishes p53-mutant...
The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform relationship between HPV vaccination subsequent risk invasive cancer are lacking.We used nationwide Swedish demographic health registers follow an open population 1,672,983 girls women who were 10 30 years age from 2006 through 2017. We assessed association cancer, controlling for at follow-up, calendar year, county...
Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant without demonstrated value prediction.We obtained the gene profiles of 159 population-derived patients, hierarchical clustering signature associated impact therapies, defined distant metastasis or death within 5 years. Independent datasets 76 treated...
Motivation: In microarray data studies most researchers are keenly aware of the potentially high rate false positives and need to control it. One key statistical shift is move away from well-known P-value discovery (FDR). Less discussion perhaps has been spent on sensitivity or associated negative (FNR). The purpose this paper explain in simple ways why FDR for assessment necessary, elucidate determining factors and, a two-sample comparative study, discuss its via sample size at design stage.
Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological (CA). Multiple BAs have been proposed are well studied individually but not jointly. We included 845 3973 repeated from a Swedish population-based cohort examined longitudinal trajectories, correlations, mortality associations nine across 20 years follow-up. found growth functional accelerated around 70; average levels BA curves differed by sex span...
SummaryBackgroundOne or two-dose schedule for human papillomavirus (HPV) vaccination has been recommended by the World Health Organization and used in many programs. We aimed to comprehensively evaluate effectiveness of quadrivalent HPV vaccine against high-grade cervical lesions age at number doses received.MethodsThis cohort study included 2,200,495 females aged 10–35 years old who were residents Sweden between 2006 2022, with 584,676 (26.6%) receiving least one dose vaccine. Poisson...
Molecular markers and the rich biological information they contain have great potential for cancer diagnosis, prognostication therapy prediction. So far, however, not superseded routine histopathology staging criteria, partly because few studies performed on molecular subtyping had little validation limited clinical characterization.We obtained gene expression data 412 breast cancers from population-based cohorts of patients Stockholm Uppsala, Sweden. Using intrinsic set approximately 500...
In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity heart failure increased liver enzymes using a Mendelian randomization study design. Please see later in the article Editors' Summary
Objective: Both rare copy number variants (CNVs) and common single-nucleotide polymorphisms (SNPs) contribute to liability schizophrenia, but their etiological relationship has not been fully elucidated. The authors evaluated an additive model whereby risk of schizophrenia requires less contribution from SNPs in the presence a CNV, tested for interactions. Method: Genetic data 21,094 case subjects with 20,227 control Psychiatric Genomics Consortium were examined. Three classes CNVs assessed:...
Incidence of condyloma, or genital warts (GW), is the earliest possible disease outcome to measure when assessing effectiveness human papillomavirus (HPV) vaccination strategies. Efficacy trials that follow prespecified inclusion and exclusion criteria may not be fully generalizable real-life HPV programs, which target a broader segment population. We assessed GW incidence after on-demand with quadrivalent vaccine using individual-level data from entire Swedish An open cohort girls women...
To compare tumor characteristics and risk factors of interval breast cancers screen-detected cancers, taking mammographic density into account.Women diagnosed with invasive cancer from 2001 to 2008 in Stockholm, Sweden, data on (n = 4,091), factors, 1,957) were included. Logistic regression was used overall by highest lowest quartiles percent density.Compared nondense breasts (≤ 20% density) significantly more likely exhibit lymph node involvement (odds ratio [OR], 3.55; 95% CI, 1.74 7.13)...
Human papillomavirus (HPV) types 16/18, included in HPV vaccines, contribute to the majority of cervical cancer, and a substantial proportion intraepithelial neoplasia (CIN) grades 2/3 or worse (CIN2+/CIN3+) including adenocarcinoma situ worse. The aim this study was quantify effect quadrivalent (qHPV) vaccination on incidence CIN2+ CIN3+. A nationwide cohort girls young women resident Sweden 2006–2013 aged 13–29 ( n = 1,333,691) followed for histologically confirmed high‐grade lesions. Data...
Abstract Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiologic differences and implicating prediction. However, reports are conflicting regarding the presence of many exposures. To examine subtype across known factors, we conducted a case–control analysis 2,632 cancers 15,945 controls in Sweden. Molecular was predicted from pathology record–derived IHC markers by classifier trained on PAM50 subtyping. Multinomial logistic regression...
Abstract Polygenic risk scores (PRSs) have become an increasingly popular approach for demonstrating polygenic influences on complex traits and establishing common signals between different traits. PRSs are typically constructed using pruning thresholding (P+T), but the best choice of parameters is uncertain; thus multiple settings used chosen. Optimization can lead to inflated Type I error. Permutation procedures correct this, they be computationally intensive. Alternatively, a single...
Determining vaccine dose-level protection is essential to minimize program costs and increase mass vaccination feasibility. Currently, a 3-dose schedule recommended for both the quadrivalent bivalent human papillomavirus (HPV) vaccines. Although primary goal of HPV programs prevent cervical cancer, condyloma related types 6 11 also prevented with represents earliest measurable preventable disease outcome vaccine.To examine association between first occurrence in relation dose...
Abstract Observational studies revealed a relationship between changes in gastric mucosa and risk of esophageal squamous cell carcinoma (ESCC) which suggested possible role for microbiota ESCC carcinogenesis. In this study we aimed to compare pattern corpus with normal esophagus. Cases were included subjects early (stage I–II) dysplasia (ESD) as the cancer precursor. Control groups age sex-matched mid-esophagus esophagitis (diseased-control) histologically esophagus (healthy-control). DNA...
Meal-Q and its shorter version, MiniMeal-Q, are 2 new Web-based food frequency questionnaires. Their meal-based interactive format was designed to promote ease of use minimize answering time, desirable improvements in large epidemiological studies.We evaluated the validity energy macronutrient intake assessed with MiniMeal-Q as well reproducibility Meal-Q.Healthy volunteers aged 20-63 years recruited from Stockholm County filled out 174-item Meal-Q. The questionnaire compared 7-day weighed...
Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since are enriched in obese individuals, it has not been easy to dissect the from those other factors. We used a Mendelian randomization approach, applying set 32 genetic markers estimate causal effect blood pressure, glycemic indices, circulating lipid levels, inflammation liver disease up 67,553 individuals. All analyses were stratified by (cutoff 55 years age) The score...
Background High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in tumor associated with subsequent prognosis ICC controversial. We aim to evaluate association between and using national registers comprehensive (HPV) genotyping. Methods findings In this nationwide population-based cohort study, we identified all diagnosed Sweden during years 2002–2011 (4,254 confirmed cases), requested archival...
Frailty index (FI) is a well-established predictor of all-cause mortality, but less known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are also understudied association between FI mortality. Furthermore, population impact frailty remains understudied.We estimated predictive value taking into account factors, tested associations time-dependent. We assessed proportion deaths that attributable to increased levels frailty. analyzed...