Marija Gamulin
A5000094560- Testicular diseases and treatments
- Prostate Cancer Treatment and Research
- Genetic Associations and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Urinary and Genital Oncology Studies
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroblastoma Research and Treatments
- Effects and risks of endocrine disrupting chemicals
- Heavy Metal Exposure and Toxicity
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- Glioma Diagnosis and Treatment
- Cancer Risks and Factors
- Pharmacological Effects and Toxicity Studies
- Ovarian cancer diagnosis and treatment
University Hospital Centre Zagreb
2016-2025
University of Zagreb
2014-2025
University Medical Center Hamburg-Eppendorf
2020
Universität Hamburg
2020
Ministry of Health
2020
University of Split
2019
Klinički Bolnički Centar Split
2019
Abstract It remains elusive whether some of the associations identified in genome-wide association studies prostate cancer (PrCa) may be due to regulatory effects genetic variants on CpG sites, which further influence expression PrCa target genes. To search for sites associated with risk, here we establish models predict methylation (N = 1,595) and conduct analyses risk (79,194 cases 61,112 controls). We identify 759 showing an association, including 15 located at novel loci. Among those 42...
Atezolizumab, a humanised monoclonal antibody targeting PD-L1, is approved for locally advanced/metastatic urothelial carcinoma. SAUL evaluated atezolizumab in broader, pretreated population, including patients ineligible the pivotal IMvigor211 phase 3 trial of atezolizumab. To determine safety and efficacy an international real-world setting. Between November 2016 March 2018 (median follow-up 12.7 mo), 1004 with advanced or metastatic nonurothelial urinary tract carcinoma who experienced...
Abstract Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS 1 ) is associated with age at prostate diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS 2 , adapted OncoArray) a multi-ethnic dataset 80,491 men (49,916 cases, 30,575 controls). any aggressive (Gleason ≥ 7, stage T3-T4, PSA 10 ng/mL, or nodal/distant metastasis)...
<h3>Importance</h3> Approximately 50% of the risk for development testicular germ cell tumors (TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet been identified. It hypothesized that inherited pathogenic DNA repair gene (DRG) alterations may drive susceptibility TGCTs. <h3>Objective</h3> To systematically evaluate enrichment germline variants in cancer DRGs patients with TGCTs vs healthy controls. <h3>Design, Setting, and Participants</h3> A...
Abstract Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, international Cancer Consortium assemble 10,156 179,683 with without TGCT, respectively, for genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing total to 78, which account 44% of disease Men polygenic risk score (PRS) 95 th percentile 6.8-fold increased compared median scores. Among independent factors such as...
Abstract Background Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs a prostate polygenic hazard score (PHS) would improve associations with clinically significant multi-ancestry datasets. Methods In total, 299 previously associated were inclusion new PHS, LASSO-regularized...
We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: Croatian cohort, consisting 62 cases 30 controls, Serbian 41 61 controls. Blood/serum samples collected. Levels investigated metal(oid)s, parameters oxidative stress, prostate-specific antigen (PSA) determined collected samples. A comparison measured between 103 cancer patients 91 control men from both showed significantly higher blood SOD, GPx...
Altered folate levels may play an important role in colon carcinogenesis. The aim of this study was to investigate the association polymorphisms key folate-metabolizing genes with susceptibility sporadic cancer. Six common (two MTHFR and one each MTR, MTRR, RFC1, DHFR genes) were genotyped 300 healthy subjects cancer patients from Croatia. Obtained results indicate possible protective MTRR 66 AA (OR=0.655; 95% CI=0.441-0.973; p=0.04). Maximum-likelihood analysis haplotypes revealed a linkage...
Development of graphical/visual presentations cancer etiology caused by environmental stressors is a process that requires combining the complex biological interactions between xenobiotics in living and occupational environment with genes (gene-environment interaction) genomic non-genomic based disease specific mechanisms organisms. Traditionally, presentation causal relationships includes statistical association exposure to one xenobiotic corrected for effect potential confounders. Within...
As in disease recurrence, providing clinicians with the exact extent of at time initial diagnosis is key management and individual treatment prostate cancer (PC) patients. Intending to examine usefulness gallium- 68 PSMA-11 positron emission tomography/computed tomography ([68Ga]Ga-PSMA-11 PET/CT) determine if there a correlation between prostate-specific antigen (PSA) serum values, WHO/ISUP (World Health Organization/International Society Urological Pathology's) grade group tumor SUVmax...
Abstract: Toxic effects of the antineoplastic drug irinotecan on human blood cells at concentrations 9.0 µg/ml and 4.6 were evaluated in vitro . Using alkaline neutral comet assay significantly increased levels primary DNA damage lymphocytes detected. The induction apoptosis/necrosis, as determined by a fluorescent assay, was also notably increased. Cytogenetic outcomes treatment assessed analysis structural chromosome aberrations fluorescence situ hybridization. A higher incidence chromatid...
Aims and Background Recent publications of breast cancer classification based on gene expression profile analyses indicate that medullary carcinomas (MBC) may be considered part the basal-like carcinoma spectrum made up ER-negative, PR-negative HER-2-negative cells (“triple-negative phenotype”). On other hand, there are also data showing a proportion MBC atypical (AMBC) is ER, PR and/or HER-2 positive. Therefore, we have decided to immunohistochemically analyze PR, basal/myoepithelial...
We investigated the expression of tumor-associated antigens (TAA) cancer/testis (C/T) gene family in cervical squamous cell carcinomas. First, we focused on HeLa cancer derived line, and found that it expresses MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A12, GAGE-3/6, LAGE-1, PRAME genes, encoding defined C/T TAA. In contrast, no MAGE-A10, BAGE, GAGE-1/2, or NY-ESO-1 genes was observed. Corresponding products could also be detected by immunoblotting immunocytochemistry, taking...
Genome-wide association studies in patients with testicular germ-cell tumors (TGCT) from Great Britain and the United States have identified six susceptibility loci or near biologically plausible candidate genes. However, these not been replicated an independent European sample. We performed a genetic replication study of previously TGCT Croatian case-control sample additional analyses as concerning histological subtypes tumor staging. analyzed single-nucleotide polymorphisms [rs2900333...