A5073816822- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Cancer, Lipids, and Metabolism
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Genetic and phenotypic traits in livestock
- Nutritional Studies and Diet
- Gene expression and cancer classification
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Pelvic floor disorders treatments
- Physical Activity and Health
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Glutathione Transferases and Polymorphisms
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Lipoproteins and Cardiovascular Health
- Antioxidant Activity and Oxidative Stress
- Birth, Development, and Health
University of Tennessee Health Science Center
2018-2025
Vanderbilt University Medical Center
2014-2024
Center for Cancer Research
2023-2024
Los Alamos National Laboratory
2023
Durham VA Medical Center
2022
Duke-NUS Medical School
2022
North Carolina State University
2022
North Carolina Central University
2022
UC Irvine Health
2022
University of California, Irvine
2022
Open AccessJournal of UrologyAdult Urology1 Jan 2019Toileting Behaviors Women—What is Healthy? Casey G. Kowalik, Adam Daily, Sophia Delpe, Melissa R. Kaufman, Jay Fowke, Roger Dmochowski, and W. Stuart Reynolds KowalikCasey Kowalik *Correspondence: Department Urologic Surgery, Vanderbilt University Medical Center, A1302 Center North, Nashville, Tennessee 37232 (telephone: 615-343-1317; FAX: 615-322-8990; e-mail: E-mail Address: [email protected]). , DailyAdam Daily DelpeSophia Delpe...
Abstract Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS 1 ) is associated with age at prostate diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS 2 , adapted OncoArray) a multi-ethnic dataset 80,491 men (49,916 cases, 30,575 controls). any aggressive (Gleason ≥ 7, stage T3-T4, PSA 10 ng/mL, or nodal/distant metastasis)...
A previous-day recall (PDR) may be a less error-prone alternative to traditional questionnaire-based estimates of physical activity and sedentary behavior (e.g., past year), but the validity method is not established. We evaluated an interviewer administered PDR in adolescents (12-17 yr) adults (18-71 yr).
Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between level F2-isoprostanes, a validated biomarker oxidative stress, and high grade prostatic intraepithelial neoplasia.This case-control analysis within Nashville Men's Health Study included men recruited at biopsy. Body morphometrics, health history urine were collected from more than 2,000 before F2-isoprostanes measured gas chromatography/mass spectrometry an age matched sample...
There is limited evidence demonstrating the benefits of physical activity with regard to mortality risk or harms associated sedentary behavior in black adults, so we examined relationships between these health behaviors and cause-specific a prospective study that had large proportion adults. Participants (40–79 years age) enrolled Southern Community Cohort Study 2002 2009 (n = 63,308) were prospectively followed over 6.4 years, 3,613 1,394 deaths occurred blacks whites, respectively. Black...
Abstract Objective: Several genome–wide association studies (GWAS) have demonstrated that common genetic variants contribute to obesity. However, of this complex trait focused on ancestrally European populations, despite the high prevalence obesity in some minority groups. Design and Methods: As part “Population Architecture using Genomics Epidemiology (PAGE)” Consortium, we investigated between 13 GWAS‐identified single‐nucleotide polymorphisms (SNPs) BMI 69,775 subjects, including 6,149...
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported Martinican men with early-onset prostate cancer. Given the role of variation cancer, we investigated association between X285K and cancer risk a large sample 22 361 ancestry men, including 11 688 cases. The allele present only West ancestry, an frequency that ranged from 0.40% Ghana 0.31% Nigeria to 0% Uganda South Africa, range frequencies admixed North America Europe (0-0.26%)....
Abstract BACKGROUND. Prior studies suggest that obese men have lower prostate‐specific antigen (PSA) levels than leaner men. Caucasian (CA) also may PSA African‐American (AA) men, but the relevance of body size to racial disparities in is unclear. The association between mass index (BMI) and height on percentage free (%fPSA) was investigated within AA CA without a prior prostate cancer diagnosis. METHODS. (n = 150) 149) similar socioeconomic status completed an extensive in‐person interview...
Background Ionized calcium (Ca) and magnesium (Mg) compete as essential messengers to regulate cell proliferation inflammation. We hypothesized that inadequate Mg levels, perhaps relative Ca levels (e.g. a high Ca/Mg ratio) are associated with greater prostate cancer risk. Study Design In this biomarker sub-study of the Nashville Men's Health (NMHS), we included 494 NMHS participants, consisting 98 high-grade (Gleason≥7) 100 low-grade cases, 133 intraepithelial neoplasia (PIN) 163 controls...
Obesity and physical activity have been posited as modifiable risk factors to delay lower urinary tract symptom progression. In this study we determined the independent associations of obesity with symptoms at followup among white African-American men.Male participants 40 79 years old were identified from Southern Community Cohort Study, a prospective cohort based in southeastern United States. Baseline data collection included validated questionnaire, height weight, health history other...
Established risk factors for prostate cancer have not translated to effective prevention or adjuvant care strategies. Several epidemiologic studies suggest greater body adiposity may be a modifiable factor high-grade (Gleason 7, Gleason 8-10) and mortality. However, BMI only approximates adiposity, confounded by centralized fat deposition lean mass in older men. Our objective was use bioelectric impedance analysis (BIA) measure composition determine the association between total (FM)...
BACKGROUND Follow‐through of a positive screening test is necessary to reap the potential benefits cancer screening. Racial variation in follow‐through diagnostic care may underlie proportion known disparity prostate mortality. The authors used data from arm Prostate, Lung, Colorectal, and Ovarian (PLCO) trial determine whether race associated with use follow‐up testing after initial evaluation. METHODS Men who had prostate‐specific antigen (PSA) level >4 ng/mL at any time during study...
Background BPH is a common disease associated with age and obesity. However, the biological pathways between obesity are unknown. Our objective was to investigate biomarkers of systemic prostate tissue inflammation as potential mediators association. Methods Participants included 191 men without cancer at biopsy. Trained staff measured weight, height, waist hip circumferences, body composition by bioelectric impedance analysis. Systemic estimated serum IL-6, IL-1β, IL-8, TNF-α; urinary...
BACKGROUND Benign prostatic hyperplasia (BPH) is a common, chronic progressive disease. Inflammation associated with enlargement and resistance to 5α‐reductase inhibitor (5ARI) therapy. Activation of the nuclear factor‐kappa B (NF‐κB) pathway linked both inflammation ligand‐independent prostate cancer progression. METHODS NF‐κB activation androgen receptor variant (AR‐V) expression were quantified in transition zone tissue samples from patients wide range AUASS incidental BPH treated for low...
Although men of African ancestry have a high risk prostate cancer (PCa), no genes or mutations been identified that contribute to familial clustering PCa in this population. We investigated whether the ancestry–specific variant at 8q24, rs72725854, is enriched with family history 9052 cases, 143 cases from high-risk families, and 8595 controls ancestry. found allele be significantly associated earlier age diagnosis, more aggressive disease, (32% carried vs 23% without 12% controls). For two...