A5024640253- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Epigenetics and DNA Methylation
- Childhood Cancer Survivors' Quality of Life
- Prostate Cancer Treatment and Research
- Bioinformatics and Genomic Networks
- Infant Development and Preterm Care
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Head and Neck Cancer Studies
- Behavioral Health and Interventions
- RNA Research and Splicing
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Urban Transport and Accessibility
- Genetic and phenotypic traits in livestock
- Pancreatitis Pathology and Treatment
- Prostate Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
Seattle Children's Hospital
2013-2018
Fred Hutch Cancer Center
2002-2014
Seattle University
2014
University of Washington
2003-2010
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2005-2010
Cancer Research Center
2005-2009
A multi-ethnic study demonstrates that the extrapolation of genetic disease risk models from European populations to other ethnicities is compromised more strongly by structure than environmental or global background in differential associations across ethnicities.
Although pancreatic cancer has an extremely high case fatality rate, little is known about differences in mortality by histologic types. We examined median survival and risk of for endocrine tumors two types exocrine tumors, adenocarcinomas, mucinous tumors.This analysis included 35,276 cases reported to the nine population-based registries participating Surveillance, Epidemiology, End Results program from 1973 2000. Survival among with were compared using Kaplan-Meier plots. Comparative...
Using a phenome-wide association study (PheWAS) approach, we comprehensively tested genetic variants for with phenotypes available 70,061 participants in the Population Architecture using Genomics and Epidemiology (PAGE) network. Our aim was to better characterize architecture of complex traits identify novel pleiotropic relationships. This PheWAS drew on five population-based studies representing four major racial/ethnic groups (European Americans (EA), African (AA),...
The field of phenomics has been investigating network structure among large arrays phenotypes, and genome-wide association studies (GWAS) have used to investigate the relationship between genetic variation single diseases/outcomes. A novel approach emerged combining both exploration phenotypic genotypic variation, known as phenome-wide study (PheWAS). Population Architecture using Genomics Epidemiology (PAGE) is a National Human Genome Research Institute (NHGRI)-supported collaboration four...
Abstract Objective: Several genome–wide association studies (GWAS) have demonstrated that common genetic variants contribute to obesity. However, of this complex trait focused on ancestrally European populations, despite the high prevalence obesity in some minority groups. Design and Methods: As part “Population Architecture using Genomics Epidemiology (PAGE)” Consortium, we investigated between 13 GWAS‐identified single‐nucleotide polymorphisms (SNPs) BMI 69,775 subjects, including 6,149...
The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, anthropometric trait loci includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated 5,863 African Americans; 89% all passed rigorous quality control with call rate 99.9%. Two examples illustrate value African-ancestry populations. At CELSR2/PSRC1/SORT1, we found strongest associated...
Genetic variants in intron 1 of the fat mass– and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) Europeans. However, follow-up studies African Americans (AA) shown no support for some most BMI–associated FTO single nucleotide polymorphisms (SNPs). This is likely explained by different race-specific linkage disequilibrium (LD) patterns lower correlation overall AA, which provides opportunity to fine-map this region narrow on functional variant. To...
Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction association with 20 T2D generalizes across six major racial/ethnic groups U.S. as part Population Architecture using Genomics Epidemiology Consortium (16,235 case 46,122 control subjects American, African Hispanic, East Asian, American Indian, Native Hawaiian ancestry). The percentage positive (odds ratio [OR] >1 putative allele)...
To assess the construct validity and responsiveness of Pediatric Quality Life Inventory 4.0 Generic Core Scales Infant in medical-surgical (PICU) cardiac PICU.Prospective cohort study 367 inpatients admitted either to PICU or ICU at Seattle Children's Hospital from January 2012 June 2013. Parent/caregiver child (≥ 8 yr old, developmentally appropriate, critical illness resolved) scores were obtained within 24 hours PICU/cardiac discharge subsequently 4-12 weeks following hospital discharge....
We examined the association between HNF1B variants identified in a recent genome-wide study and endometrial cancer two large case-control studies nested prospective cohorts: Multiethnic Cohort Study (MEC) Women's Health Initiative (WHI) as part of Population Architecture using Genomics Epidemiology (PAGE) study. A total 1,357 incident cases invasive 7,609 controls were included analysis (MEC: 426 cases/3,854 controls; WHI: 931cases/3,755 controls). The majority women WHI European American,...
Increasing physical activity is currently considered to be a possible prevention strategy for cancer, obesity, and cardiovascular disease, either alone or in combination with dietary changes. This paper presents results of randomized trial moderate-to-vigorous intensity exercise middle aged, sedentary women; specifically, we report changes correlates quality life functional status this intervention program both the short (three months) longer term (12 months). The group showed significant...
Evidence is limited as to whether heritable risk of obesity varies throughout adulthood. Among >34,000 European Americans, aged 18-100 years, from multiple U.S. studies in the Population Architecture using Genomics and Epidemiology (PAGE) Consortium, we examined evidence for heterogeneity associations five established variants (near FTO, GNPDA2, MTCH2, TMEM18, NEGR1) with BMI across four distinct epochs adulthood: 1) young adulthood (ages 18-25 years), 26-49 middle-age 50-69 older ≥70...
OBJECTIVES: Seattle Children’s Hospital sought to optimize the value equation for neonatal jaundice patients by creating a standard care pathway. METHODS: An evidence-based pathway management of was created. This included multidisciplinary team assembly, comprehensive literature review, creation treatment algorithm and computer order sets, formulation goals metrics, roll-out an education program end users, ongoing improvement. The implemented on May 31, 2012. Quality metrics before after...
Abstract Concurrent with increasing prostate cancer incidence and declining mortality in the United States, prevalence of obesity has been steadily. Several studies have reported that is associated increased risk high-grade mortality, it thus likely increase burden cancer. In this study, we assess potential effect on mortality. We first estimate obesity-associated relative risks low- using data from Prostate Cancer Prevention Trial. Then, National Health Nutrition Examination Survey...
<h3>Objective</h3> To identify factors associated with interruption or early discontinuation of treatment in patients receiving radiotherapy for head and neck cancer, because it is believed that such increases the risk disease relapse adversely influences survival. <h3>Design, Setting, Patients</h3> Using Surveillance, Epidemiology, End Results (SEER)–Medicare linked database, we identified Medicare beneficiaries 66 years older who were diagnosed as having local regional cancer from January...
Abstract BACKGROUND: Studies of lung cancer disparities between American Indians and Alaska Natives (AIANs) whites have yielded mixed results. To the authors' knowledge, no studies to date investigated whether race‐based differences in histology could explain survival disparities. METHODS: Data were obtained on AIANs with from 17 population‐based registries participating Surveillance, Epidemiology, End Results (SEER) program 1973 2006. Logistic regression was used determine race other...
Physical activity is associated with long-term benefits for health and tracks from early childhood into later adolescence. Limited information exists about factors influencing physical among Latino preschoolers. We aimed to identify correlates of objectively measured light-to-vigorous-intensity as a proportion wear time (% PA) in 3-5 year olds.Latino preschoolers (n = 96) were recruited Head Start centers Houston, TX, USA, 2009 2010. Sociodemographics, anthropometrics, acculturation,...