A5007319489- Cardiac electrophysiology and arrhythmias
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Asthma and respiratory diseases
- Lipoproteins and Cardiovascular Health
- Pharmaceutical studies and practices
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Heart Failure Treatment and Management
- Drug-Induced Adverse Reactions
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Dementia and Cognitive Impairment Research
- Heart Rate Variability and Autonomic Control
- Metabolism, Diabetes, and Cancer
- Inflammatory mediators and NSAID effects
- Receptor Mechanisms and Signaling
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2024
Dutch Health Care Inspectorate
2012-2021
National University of Singapore
2020
New York University
2020
Netherlands Heart Institute
2020
Leiden University Medical Center
1995-2019
Universidade Federal de Minas Gerais
2019
Queen Mary University of London
2019
The Netherlands Cancer Institute
2019
Aims We aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in a large European population-based study. Methods results The study is part Rotterdam study, prospective cohort among subjects aged 55 years above. at baseline was assessed 6808 participants. Incidence AF investigated during mean follow-up period 6.9 6432 persons. identified 376 prevalent 437 incident cases. Overall 5.5%, rising from 0.7% age group 55–59 17.8% those 85 overall rate 9.9/1000 person–years....
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Netherlands. targets cardiovascular, neurological, ophthalmological and endocrine diseases. As 2008 about 15,000 subjects aged 45 years or over comprise cohort. findings have been presented some 600 research articles reports (see http://www.epib.nl/rotterdamstudy). This article gives reasons for its design. It also presents summary major an update objectives methods.
Since atrial fibrillation (AF) is associated with increased risks of cardiovascular and cerebrovascular complications, estimations on the number individuals AF are relevant to healthcare planning. We aimed project in Netherlands European Union from 2000 2060. Age- sex-specific prevalence estimates were obtained prospective community-based Rotterdam Study. Population projections for Union's statistics office. In age stratum 55–59 years, was 1.3% men (95% CI: 0.4–3.6%) 1.7% women 0.7–4.0%)....
Previous studies have suggested that the use of nonsteroidal antiinflammatory drugs (NSAIDs) may help to prevent Alzheimer's disease. The results, however, been inconsistent.
Background Tools for the prediction of atrial fibrillation ( AF ) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark test novel putative risk factors. Methods Results Individual‐level data 3 large cohorts in U nited S tates (Atherosclerosis Risk Communities [ ARIC ] study, Cardiovascular Health Study CHS ], Framingham Heart FHS ]), including 18 556 men women aged 46 94 years (19% A frican mericans, 81% whites) were pooled derive...
Confounding by indication is a term used when variable rise factor for disease among nonexposed persons and associated with the exposure of interest in population form which cases derive, without being an intermediate step causal pathway between disease. However, literature, confounding indicationis not always consistently. The authors found three different situations has been applied or might have but was not: as protopathic bias, severity, selection bias. It be helpful to limit use...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Netherlands. targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being expanded by persons 40 over. findings have been presented 1500 research articles reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives...
Aim Falls in the elderly are common and often serious. We studied association between multiple drug use (polypharmacy) falls elderly. Methods This was a population‐based cross‐sectional study, part of Rotterdam Study. The participants were 6928 individuals aged ≥ 55 years. prevalence previous year assessed. Medication determined with an interviewer‐administered questionnaire verification use. Polypharmacy defined as four or more drugs per day. Results strongly increased age. women than men....
The Rotterdam Study is an ongoing prospective cohort study that started in 1990 the city of Rotterdam, Netherlands. aims to unravel etiology, preclinical course, natural history and potential targets for intervention chronic diseases mid-life late-life. focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being...
Cross-sectional reports suggest that statin users are less likely to have Alzheimer disease (AD). Prospective studies provided inconsistent evidence. Moreover, it is unclear whether the association differs for lipophilic statins, those could more easily pass blood-brain barrier and hydrophilic statins.To prospectively evaluate use of statins associated with risk AD, determine associations differ statins.6992 participants prospective, population-based Rotterdam Study were followed, from...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Netherlands. targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. findings have been presented 1200 research articles reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives rationale its design. It also presents summary...
It remains unclear if inflammation itself may induce cancer, is a result of tumor growth, or combination both exists. The aim this study was to examine whether C-reactive protein (CRP) levels and CRP gene variations were associated with an altered risk colorectal, lung, breast, prostate cancer.A total 7,017 participants age > = 55 years from the Rotterdam Study eligible for analyses. Mean follow-up time 10.2 years. High-sensitivity measurements performed identify additional values 0.2 1.0...
The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines introduced a prediction model and lowered the threshold for treatment with statins to 7.5% 10-year hard atherosclerotic cardiovascular disease (ASCVD) risk. Implications new guideline's have not been addressed in non-US populations or compared previous guidelines.To determine population-wide implications ACC/AHA, Adult Treatment Panel III (ATP-III), European Society Cardiology (ESC) using cohort Dutch...