A5080884343- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy and preeclampsia studies
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Peripheral Artery Disease Management
- Statistical Methods and Inference
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Coronary Interventions and Diagnostics
- Congenital Heart Disease Studies
- Psychotherapy Techniques and Applications
- Personality Disorders and Psychopathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood Pressure and Hypertension Studies
- Acute Ischemic Stroke Management
- Inflammatory Bowel Disease
- Airway Management and Intubation Techniques
Leiden University Medical Center
2013-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Leiden University
2007-2017
Erasmus MC
1997-2015
University College London
2015
Radboud University Nijmegen
1999-2014
Netherlands Consortium for Healthy Ageing
2014
Loyola University Medical Center
2008-2013
Erasmus University Rotterdam
2000-2010
University Medical Center
2003-2010
Aims We aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in a large European population-based study. Methods results The study is part Rotterdam study, prospective cohort among subjects aged 55 years above. at baseline was assessed 6808 participants. Incidence AF investigated during mean follow-up period 6.9 6432 persons. identified 376 prevalent 437 incident cases. Overall 5.5%, rising from 0.7% age group 55–59 17.8% those 85 overall rate 9.9/1000 person–years....
Previous studies have suggested that the use of nonsteroidal antiinflammatory drugs (NSAIDs) may help to prevent Alzheimer's disease. The results, however, been inconsistent.
Objective: To investigate the risk of AD associated with a family history dementia, female gender, low levels education, smoking, and head trauma.Background: These putative factors have been identified in cross-sectional studies. However, those studies are prone to bias due systematic differences between patients control subjects regarding survival how recalled.Methods: The authors performed pooled analysis four European population-based prospective individuals 65 years older, 528 incident...
Background Dialectical behaviour therapy (DBT) is widely considered to be a promising treatment for borderline personality disorder (BPD). However, the evidence its efficacy published thus far should regarded as preliminary. Aims To compare effectiveness of DBT with usual patients BPD and examine impact baseline severity on effectiveness. Method Fifty-eight women were randomly assigned either 12 months or in randomised controlled study. Participants recruited through clinical referrals from...
<h3>Background</h3> Increased levels of inflammatory proteins have been found in the brains and plasma samples patients with dementia. Whether are elevated before clinical onset dementia is unclear. <h3>Objective</h3> To determine whether high associated an increased risk <h3>Design Setting</h3> A case-cohort study within Rotterdam Study, a population-based prospective cohort Netherlands. <h3>Participants</h3> The source population comprises 6713 subjects who, at baseline (1990-1993), were...
<b><i>Objective:</i></b> To study the difference in risk for dementing diseases between men and women. <b><i>Background:</i></b> Previous studies suggest women have a higher dementia than men. However, these include small sample sizes, particularly older age groups, when incidence of is highest. <b><i>Methods:</i></b> Pooled analysis four population-based prospective cohort was performed. The included persons 65 years older, 528 incident cases dementia, 28,768 person-years follow-up....
We consider random effects meta-analysis where the outcome variable is occurrence of some event interest. The data structures handled are one has or more groups in each study, and group either number subjects with without event, events total duration follow-up available. Traditionally, follows summary measures approach based on estimates measure(s) corresponding standard error(s). This assumes an approximate normal within-study likelihood treats errors as known. several potential...
Vacuum‐assisted closure has become a new technique in the challenging management of contaminated, acute, and chronic wounds. Although promising clinical results have been described, scientific proof to substantiate mechanism action this therapy is scarce. In present study, we examined whether positive effect on wound healing found vacuum‐assisted closure–treated wounds could be explained by an bacterial load. Fifty‐four patients who needed open before surgical were included study. Wounds...
To assess age-, sex-, and subtype-specific incidence rates of dementia to calculate the risk dementia, authors performed a large, community-based, prospective cohort study on as part Rotterdam Study. Participants were recruited among residents suburb Rotterdam, aged 55 yearsand older. Baseline examinations took place between 1990 1993. The average follow-up was 2.1 years. Screening for followed three-stage protocol. Medical records subjects who had died or couldnot be examined in person...
Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been proposed as an inflammatory marker of cardiovascular disease. In the present study, we investigated whether Lp-PLA2 is independent predictor coronary heart disease and ischemic stroke.The Rotterdam Study a population-based follow-up study in 7983 subjects > or =55 years age. We performed case-cohort including 308 cases, 110 stroke random sample 1820 subjects. used Cox proportional-hazard models with modification standard errors based...
The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) growing. Recent case-control studies demonstrated association between the complement factor H (CFH) gene, a regulator of complement, and AMD.To assess associations CFH gene AMD general population to investigate modifying effect smoking, serum inflammatory markers, genetic variation C-reactive protein (CRP).Population-based, prospective cohort study individuals aged 55 years or older (enrollment...
Meta-analysis of receiver operating characteristic (ROC)-curve data is often done with fixed-effects models, which suffer many shortcomings. Some random-effects models have been proposed to execute a meta-analysis ROC-curve data, but these are not used in practice. Straightforward modeling techniques for multivariate needed. The 1st aim this article present practical method that addresses the drawbacks fixedeffects summary ROC (SROC) Littenberg and Moses. Sensitivities specificities analyzed...
Recent randomized trials have proven the benefit of intra-arterial treatment (IAT) with retrievable stents in acute ischemic stroke. Patients poor or absent collaterals (preexistent anastomoses to maintain blood flow case a primary vessel occlusion) may gain less clinical from IAT. In this post hoc analysis, we aimed assess whether effect IAT was modified by collateral status on baseline computed tomographic angiography Multicenter Randomized Clinical Trial Endovascular Treatment Acute...