Kerrin S. Small

ORCID: 0000-0003-4566-0005
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About
Contact & Profiles
Research Areas
  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Genetic Mapping and Diversity in Plants and Animals
  • Bioinformatics and Genomic Networks
  • RNA modifications and cancer
  • Adipose Tissue and Metabolism
  • RNA Research and Splicing
  • Genetic and phenotypic traits in livestock
  • Gene expression and cancer classification
  • Nutrition, Genetics, and Disease
  • Cancer-related molecular mechanisms research
  • Genomics and Rare Diseases
  • Adipokines, Inflammation, and Metabolic Diseases
  • Diet and metabolism studies
  • Liver Disease Diagnosis and Treatment
  • Pancreatic function and diabetes
  • Cancer-related gene regulation
  • Genetic Syndromes and Imprinting
  • Dental Health and Care Utilization
  • Pediatric health and respiratory diseases
  • Metabolomics and Mass Spectrometry Studies
  • Genomic variations and chromosomal abnormalities
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Malaria Research and Control
  • Lipid metabolism and disorders

King's College London
2016-2025

St Thomas' Hospital
2011-2025

King's College - North Carolina
2024

Centre for Human Genetics
2007-2016

University of Oxford
2008-2016

Leiden University Medical Center
2015

Wellcome Sanger Institute
2007-2014

London School of Hygiene & Tropical Medicine
2010

Stanford University
2004-2007

Stanford Medicine
2007

Shane McCarthy Sayantan Das Warren W. Kretzschmar Olivier Delaneau Andrew R. Wood and 95 more Alexander Teumer Hyun Min Kang Christian Fuchsberger Petr Danecek Kevin Sharp Yang Luo Carlo Sidore Alan Kwong Nicholas J. Timpson Seppo Koskinen Scott Vrieze Laura J. Scott He Zhang Anubha Mahajan Jan H. Veldink Ulrike Peters Carlos N. Pato Cornelia M. van Duijn Christopher E. Gillies Ilaria Gandin Massimo Mezzavilla Arthur Gilly Massimiliano Cocca Michela Traglia Andrea Angius Jeffrey C. Barrett Dorrett Boomsma Kari Branham Gerome Breen Chad M. Brummett Fabio Busonero Harry Campbell Andrew T. Chan Sai Chen Emily Y. Chew Francis S. Collins Laura J. Corbin George Davey Smith George Dedoussis Marcus Dörr Aliki-Eleni Farmaki Luigi Ferrucci Lukas Forer Ross M. Fraser Stacey Gabriel Shawn Levy Leif Groop Tabitha A. Harrison Andrew T. Hattersley Oddgeir L. Holmen Kristian Hveem Matthias Kretzler James Lee Matt McGue Thomas Meitinger David Melzer Josine L. Min Karen L. Mohlke John B. Vincent Matthias Nauck Deborah A. Nickerson Aarno Palotie Michele T. Pato Nicola Pirastu Melvin G. McInnis J. Brent Richards Cinzia Sala Veikko Salomaa David Schlessinger Sebastian Schoenherr P. Eline Slagboom Kerrin S. Small Timothy D. Spector Dwight Stambolian Marcus A. Tuke Jaakko Tuomilehto Leonard H. van den Berg Wouter van Rheenen Uwe Völker Cisca Wijmenga Daniela Toniolo Eleftheria Zeggini Paolo Gasparini Matthew G. Sampson James F. Wilson Timothy M. Frayling Paul I. W. de Bakker Morris A. Swertz Steven A. McCarroll Charles Kooperberg Annelot M. Dekker David Altshuler Cristen J. Willer William G. Iacono Samuli Ripatti

10.1038/ng.3643 article EN Nature Genetics 2016-08-22

Age-related changes in DNA methylation have been implicated cellular senescence and longevity, yet the causes functional consequences of these variants remain unclear. To elucidate role age-related epigenetic healthy ageing potential we tested for association between whole-blood patterns 172 female twins aged 32 to 80 with age phenotypes. Twin-based levels at 26,690 CpG-sites showed evidence mean genome-wide heritability 18%, which was supported by identification 1,537 QTLs cis FDR 5%. We...

10.1371/journal.pgen.1002629 article EN cc-by PLoS Genetics 2012-04-19
Sarah Kim-Hellmuth François Aguet Meritxell Oliva Manuel Muñoz-Aguirre Silva Kasela and 95 more Valentin Wucher Stephane E. Castel Andrew R. Hamel Ana Viñuela Amy L. Roberts Serghei Mangul Xiaoquan Wen Gao Wang Alvaro Barbeira Diego Garrido-Martín Brian B. Nadel Yuxin Zou Rodrigo Bonazzola Jie Quan Andrew Brown Ángel Martínez-Pérez José Manuel Soria Gad Getz Emmanouil T. Dermitzakis Kerrin S. Small Matthew Stephens Hualin Simon Xi Hae Kyung Im Roderic Guigó Ayellet V. Segrè Barbara E. Stranger Kristin Ardlie Tuuli Lappalainen François Aguet Shankara Anand Kristin Ardlie Stacey Gabriel Gad Getz Aaron Graubert Kane Hadley Robert E. Handsaker Katherine Huang Seva Kashin Xiao Li Daniel G. MacArthur Samuel R. Meier Jared L. Nedzel Duyen T. Nguyen Ayellet V. Segrè Ellen Todres Brunilda Balliu Alvaro Barbeira Alexis Battle Rodrigo Bonazzola Andrew Brown Christopher D. Brown Stephane E. Castel Donald F. Conrad Daniel J. Cotter Nancy J. Cox Sayantan Das Olivia M. de Goede Emmanouil T. Dermitzakis Jonah Einson Barbara E. Engelhardt Eleazar Eskin Tiffany Eulalio Nicole M. Ferraro Elise D. Flynn Laure Frésard Eric R. Gamazon Diego Garrido-Martín Nicole R. Gay Michael J. Gloudemans Roderic Guigó Andrew R. Hame Yuan He Paul Hoffman Farhad Hormozdiari Lei Hou Hae Kyung Im Brian Jo Silva Kasela Manolis Kellis Sarah Kim-Hellmuth Alan Kwong Tuuli Lappalainen Xin Li Yanyu Liang Serghei Mangul Pejman Mohammadi Stephen B. Montgomery Manuel Muñoz-Aguirre Daniel Nachun Andrew B. Nobel Meritxell Oliva YoSon Park Yongjin Park Princy Parsana Abhiram Rao

Cell type composition, estimated from bulk tissue, maps the cellular specificity of genetic variants.

10.1126/science.aaz8528 article EN Science 2020-09-10

While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity multiple primary tissues is not yet well understood. We explore depth role cis-regulatory three human tissues: lymphoblastoid cell lines (LCL), skin, and fat. The samples (156 LCL, 160 166 fat) were derived simultaneously from a subset well-phenotyped healthy female twins MuTHER resource. discover an abundance cis-eQTLs each tissue similar to previous estimates (858 4.7%...

10.1371/journal.pgen.1002003 article EN cc-by PLoS Genetics 2011-02-03

Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, function of variation how it regulated by genetic environmental factors. We utilized Multiple Tissue Human Expression Resource (MuTHER) generated Illumina 450K adipose methylome data from 648 twins. found that individual CpGs had low variance variability was suppressed promoters. noted highly heritable...

10.1016/j.ajhg.2013.10.004 article EN cc-by The American Journal of Human Genetics 2013-10-31

Abstract Background Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines 856 female twins range 39-85 years. Additionally, we investigated genotypic variants involved genotype-by-age interactions understand how genomic regulation alters Results Using a linear mixed model, differential was...

10.1186/gb-2013-14-7-r75 article EN cc-by Genome biology 2013-07-26
Pirro G. Hysi Ching‐Yu Cheng Henriët Springelkamp Stuart MacGregor Jessica N. Cooke Bailey and 86 more Robert Wojciechowski Véronique Vitart Abhishek Nag Alex W. Hewitt René Höhn Cristina Venturini Alireza Mirshahi Wishal D. Ramdas Guðmar Þorleifsson Eranga N. Vithana Chiea Chuen Khor Arni B Stefansson Jiemin Liao Jonathan L. Haines Najaf Amin Ya Xing Wang Philipp S. Wild Ayse Bilge Ozel Jun Z. Li Brian W. Fleck Tanja Zeller Sandra E. Staffieri Yik-Ying Teo Gabriel Cuéllar-Partida Xiaoyan Luo R. Rand Allingham Julia E. Richards Andrea Senft Lennart C. Karssen Yingfeng Zheng Céline Bellenguez Liang Xu Adriana I. Iglesias James F. Wilson Jae H. Kang Jin‐Moo Lee Vésteinn Jónsson Unnur Þorsteinsdóttir Dominiek D. G. Despriet Sarah Ennis Sayoko E. Moroi Nicholas G. Martin Nomdo M. Jansonius Seyhan Yazar E Shyong Tai Philippe Amouyel James Kirwan Leonieke M. E. van Koolwijk Michael A. Hauser Friðbert Jónasson Paul Leo Stephanie Loomis Rhys Fogarty Fernando Rivadeneira Lisa S. Kearns Karl J. Lackner Paulus T.V.M. de Jong Claire L. Simpson Craig E. Pennell Ben A. Oostra André G. Uitterlinden Seang‐Mei Saw Andrew Lotery Joan E. Bailey‐Wilson Albert Hofman Johannes R. Vingerling C. Maubaret Norbert Pfeiffer Roger C. W. Wolfs Hans G. Lemij Terri L. Young Louis R. Pasquale Cécile Delcourt Timothy D. Spector Caroline C. W. Klaver Kerrin S. Small Kathryn P. Burdon Kári Stéfansson Tien Yin Wong Ananth C. Viswanathan David A. Mackey Jamie E. Craig Janey L. Wiggs Cornelia M. van Duijn Christopher J. Hammond Tin Aung

10.1038/ng.3087 article EN Nature Genetics 2014-08-31

Background The association between current tobacco smoking, the risk of developing symptomatic COVID-19 and severity illness is an important information gap. Methods UK users Zoe Symptom Study app provided baseline data including demographics, anthropometrics, smoking status medical conditions, were asked to log their condition daily. Participants who reported that they did not feel physically normal then by complete a series questions, 14 potential symptoms about hospital attendance. main...

10.1136/thoraxjnl-2020-216422 article EN Thorax 2021-01-05

10.1038/s41588-021-00969-x article EN Nature Genetics 2022-01-01
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