Kerrin S. Small
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Dental Health and Care Utilization
- Pediatric health and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Malaria Research and Control
- Lipid metabolism and disorders
King's College London
2016-2025
St Thomas' Hospital
2011-2025
King's College - North Carolina
2024
Centre for Human Genetics
2007-2016
University of Oxford
2008-2016
Leiden University Medical Center
2015
Wellcome Sanger Institute
2007-2014
London School of Hygiene & Tropical Medicine
2010
Stanford University
2004-2007
Stanford Medicine
2007
Age-related changes in DNA methylation have been implicated cellular senescence and longevity, yet the causes functional consequences of these variants remain unclear. To elucidate role age-related epigenetic healthy ageing potential we tested for association between whole-blood patterns 172 female twins aged 32 to 80 with age phenotypes. Twin-based levels at 26,690 CpG-sites showed evidence mean genome-wide heritability 18%, which was supported by identification 1,537 QTLs cis FDR 5%. We...
Cell type composition, estimated from bulk tissue, maps the cellular specificity of genetic variants.
While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity multiple primary tissues is not yet well understood. We explore depth role cis-regulatory three human tissues: lymphoblastoid cell lines (LCL), skin, and fat. The samples (156 LCL, 160 166 fat) were derived simultaneously from a subset well-phenotyped healthy female twins MuTHER resource. discover an abundance cis-eQTLs each tissue similar to previous estimates (858 4.7%...
Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, function of variation how it regulated by genetic environmental factors. We utilized Multiple Tissue Human Expression Resource (MuTHER) generated Illumina 450K adipose methylome data from 648 twins. found that individual CpGs had low variance variability was suppressed promoters. noted highly heritable...
Abstract Background Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines 856 female twins range 39-85 years. Additionally, we investigated genotypic variants involved genotype-by-age interactions understand how genomic regulation alters Results Using a linear mixed model, differential was...
Background The association between current tobacco smoking, the risk of developing symptomatic COVID-19 and severity illness is an important information gap. Methods UK users Zoe Symptom Study app provided baseline data including demographics, anthropometrics, smoking status medical conditions, were asked to log their condition daily. Participants who reported that they did not feel physically normal then by complete a series questions, 14 potential symptoms about hospital attendance. main...