Robert Wojciechowski
A5012703227- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- melanin and skin pigmentation
- Cerebral Venous Sinus Thrombosis
- Connexins and lens biology
- Optical Imaging and Spectroscopy Techniques
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Single-cell and spatial transcriptomics
- Genetic and phenotypic traits in livestock
- Optical Systems and Laser Technology
- Visual perception and processing mechanisms
- COVID-19 and healthcare impacts
- Ubiquitin and proteasome pathways
- Neurological diseases and metabolism
- Neutropenia and Cancer Infections
- Acne and Rosacea Treatments and Effects
- Prion Diseases and Protein Misfolding
Moorfields Eye Hospital NHS Foundation Trust
2022-2024
University College London
2022-2024
MRC Epidemiology Unit
2022-2024
University of Cambridge
2022-2024
Johns Hopkins University
2014-2024
Wojskowy Instytut Medycyny Lotniczej
2023
UK Biobank
2021
National Human Genome Research Institute
2010-2020
National Institutes of Health
2009-2020
National Association of Home Builders
2020
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) major risk factor, but many patients have normal IOP. Colocalization Mendelian randomization analysis >240 POAG IOP genome-wide association study (GWAS) loci overlapping expression splicing quantitative trait (e/sQTLs) in 49 GTEx tissues retina...
Abstract Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset between genetic variants these was investigated 5200 children assessed longitudinally across ages 7–15 years, along gene-environment interactions involving major environmental risk-factors, nearwork time outdoors. Specific could be categorized...
Myopia is the most common vision disorder and leading cause of visual impairment worldwide. However, gene variants identified to date explain less than 10% variance in refractive error, leaving majority heritability unexplained ("missing heritability"). Previously, we reported that expression APLP2 was strongly associated with myopia a primate model. Here, found low-frequency near 5'-end were error prospective UK birth cohort (n = 3,819 children; top SNP rs188663068, p 5.0 × 10−4) CREAM...
1 Department of Epidemiology, Johns Hopkins Bloomberg School Public Health, Baltimore, Maryland, United States America, 2 Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Institute (NIH), 3 Twin and Genetic King’s College London Medicine, London, Kingdom
ABSTRACT Myopia is the largest cause of uncorrected visual impairments globally and its recent dramatic increase in population has made it a major public health problem. In observational studies, educational attainment been consistently reported to be correlated myopia. Nonetheless, correlation does not imply causation. Observational studies do tell us if education causes myopia or instead there are confounding factors underlying association. this work, we use two‐step least squares...
Myopia prevalence has increased in the past 20 years, with many studies linking increase to reduced time spent outdoors. A number of recent observational have shown an inverse association between vitamin D [25(OH)D] serum levels and myopia. However, such it is difficult separate effects outdoors levels. In this work we use Mendelian randomization (MR) assess if genetically determined 25(OH)D contribute degree We performed MR using results from a meta-analysis refractive error (RE)...
To investigate age-related trends in refractive, corneal, and internal astigmatism to assess the association between lens opacity an elderly Chinese population.A population-based study was conducted among 1360 inhabitants aged 65 years older Taipei, Taiwan. Participants underwent measurements of refraction, corneal dioptric power, slit lamp biomicroscopy with grading. A total 2084 eyes were included power vector analyses Cartesian (J(0)) oblique (J(45)) components astigmatism.The crude...