Juho Wedenoja
A5041559831- Genetic Associations and Epidemiology
- Ophthalmology and Visual Impairment Studies
- Migraine and Headache Studies
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Neuroscience of respiration and sleep
- Genetics and Neurodevelopmental Disorders
- Smoking Behavior and Cessation
- Nicotinic Acetylcholine Receptors Study
- Glaucoma and retinal disorders
- Neurotransmitter Receptor Influence on Behavior
- Cognitive Abilities and Testing
- Bipolar Disorder and Treatment
- Genetic Syndromes and Imprinting
- Receptor Mechanisms and Signaling
- Traffic and Road Safety
- Autism Spectrum Disorder Research
- Personality Disorders and Psychopathology
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Fibroblast Growth Factor Research
- Reproductive System and Pregnancy
University of Helsinki
2014-2025
Helsinki University Hospital
2018-2025
Finnish Medicines Agency Fimea
2024-2025
UK Biobank
2021
Medical Research Council
2020
Broad Institute
2020
University of Bristol
2020
Central Finland Health Care District
2019
Institute for Molecular Medicine Finland
2007-2012
Finnish Institute for Health and Welfare
2012
Abstract Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset between genetic variants these was investigated 5200 children assessed longitudinally across ages 7–15 years, along gene-environment interactions involving major environmental risk-factors, nearwork time outdoors. Specific could be categorized...
It is well known that most schizophrenia patients smoke cigarettes. There are different hypotheses postulating the underlying mechanisms of this comorbidity. We used summary statistics from large meta-analyses plasma cotinine concentration (COT), Fagerström test for nicotine dependence (FTND) and to examine genetic relationship between these traits. found risk scores calculated at P-value thresholds 5 × 10(-3) larger predicted FTND cigarettes smoked per day (CPD), suggesting genes...
Abstract Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in prophylaxis are unknown. Leveraging large-scale summary statistics for ( N cases / controls = 59,674/316,078) BP 757,601), we find positive genetic correlations diastolic (DBP, r g 0.11, P 3.56 × 10 −06 ) systolic (SBP, 0.06, 0.01), but not pulse (PP, −0.01, 0.75). Cross-trait meta-analysis reveals 14 shared loci ≤ 5 −08 ), nine which replicate < 0.05) UK Biobank. Five...
Journal Article Analysis of Detailed Phenotype Profiles Reveals CHRNA5-CHRNA3-CHRNB4 Gene Cluster Association With Several Nicotine Dependence Traits Get access Ulla Broms, Ph.D., Ph.D. 1Department Public Health, Hjelt Institute, University Helsinki, Finland2Department Mental Health and Substance Abuse Services, National Institute for Welfare, Finland Search other works by this author on: Oxford Academic PubMed Google Scholar Juho Wedenoja, M.D. Finland3Department Chronic Disease Prevention,...
Abstract Background Nearly a fifth of the world’s population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods To further elucidate these factors, we conducted genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between headache and 47 traits UK Biobank. We then tested possible causality phenotypes migraine, Mendelian randomization. In addition, attempted replication our findings in an independent...
<h3>Importance</h3> Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high (HM) hyperopia. Addressing this question is fundamental understanding genetics of refractive error has clinical relevance for genotype-based prediction children at risk HM identification new therapeutic targets. <h3>Objective</h3> To assess a common set HM, LM, <h3>Design, Setting, Participants</h3> This association study assessed unrelated...
BackgroundFetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) other genes regulating maternal responses.MethodsWe assessed sex ratios regulatory HLA-G haplotypes in population cohorts series of preeclampsia stillbirth. placental mRNA expression 136 by sequencing interferon alpha (IFNα) protein immunohistochemistry.FindingsWe found underrepresentation males...
Migraine is a highly common and debilitating disorder that often affects individuals in their most productive years of life. Previous studies have identified both genetic variants brain morphometry differences associated with migraine risk. However, the relationship between has not been examined on level, causal nature association structure risk determined. Using largest available genome-wide to date, we overlap intracranial volume, as well regional volumes nine subcortical structures. We...
Adenoviruses and other viral superficial eye infections may cause long-lasting complications, including conjunctival scarring, synechiae, lacrimal system obstructions. However, their incidence is not established. Here, we set out to assess possible oculoplastic complications need for surgical procedures in patients with adenoviral conjunctivitis. This Finnish register-based retrospective study includes conjunctivitis treated at Helsinki University Hospital clinic, Finland, during outbreak...