Caroline Ran
A5049249300- Migraine and Headache Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Biochemical effects in animals
- Genetic Associations and Epidemiology
- Lysosomal Storage Disorders Research
- Cardiovascular Syncope and Autonomic Disorders
- Nuclear Receptors and Signaling
- Circadian rhythm and melatonin
- Suicide and Self-Harm Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
- Neuropeptides and Animal Physiology
- Cerebral Venous Sinus Thrombosis
- Nicotinic Acetylcholine Receptors Study
- Neurological diseases and metabolism
- Genetics and Neurodevelopmental Disorders
- Carbohydrate Chemistry and Synthesis
- Genomic variations and chromosomal abnormalities
- Thyroid Disorders and Treatments
- Autism Spectrum Disorder Research
- Psychedelics and Drug Studies
Karolinska Institutet
2016-2025
Université de Versailles Saint-Quentin-en-Yvelines
2022-2024
Guangdong Academy of Forestry
2024
Inserm
2022-2024
Centre de recherche en Epidémiologie et Santé des Populations
2022-2024
Université Paris-Saclay
2022-2024
Center for Human Genetics
2024
Paris Cardiovascular Research Center
2023
Karolinska University Hospital
2022
University of Tübingen
2022
Abstract Background As gene‐targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction the estimated number subjects with monogenic PD worldwide currently represented in literature availability clinical data trial‐ready cohorts limited. Objective The objectives to (1) establish an international cohort affected unaffected individuals PD‐linked variants;...
The causal association between the gut microbiome and development of migraine its subtypes remains unclear.The single nucleotide polymorphisms concerning were retrieved from gene-wide study (GWAS) MiBioGen consortium. summary statistics datasets migraine, with aura (MA), without (MO) obtained GWAS meta-analysis International Headache Genetics Consortium (IHGC) FinnGen Inverse variance weighting (IVW) was used as primary method, complemented by sensitivity analyses for pleiotropy increasing...
Abstract Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in prophylaxis are unknown. Leveraging large-scale summary statistics for ( N cases / controls = 59,674/316,078) BP 757,601), we find positive genetic correlations diastolic (DBP, r g 0.11, P 3.56 × 10 −06 ) systolic (SBP, 0.06, 0.01), but not pulse (PP, −0.01, 0.75). Cross-trait meta-analysis reveals 14 shared loci ≤ 5 −08 ), nine which replicate < 0.05) UK Biobank. Five...
This study was undertaken to identify susceptibility loci for cluster headache and obtain insights into relevant disease pathways.We carried out a genome-wide association study, where 852 UK 591 Swedish cases were compared with 5,614 1,134 controls, respectively. Following quality control imputation, single variant testing conducted using logistic mixed model each cohort. The 2 cohorts subsequently combined in merged analysis. Downstream analyses, such as gene-set enrichment, functional...
Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility these associations may be explained by reverse causation.To examine using two-sample Mendelian randomisation (MR) and potential for survival incidence-prevalence biases.We used summary statistics from publicly available to estimate association genetic polymorphisms behaviors, Courage-PD (7,369 cases,...
Abstract Background Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association causal or explained by reverse causation confounding. Objective The aim to examine the between genetically predicted and PD using two‐sample Mendelian randomization (MR). Methods We genotyped well‐established instrumental variable located lactase gene (rs4988235) within Courage‐PD consortium (23 studies; 9823...
Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested related migraine recent studies, but these evidence are observational essentially and cannot infer causal relationship. present study aims reveal relationship between WM using genetic data Mendelian randomization (MR).
Background The aim of this study was to investigate clinical features a cluster headache cohort in Sweden and construct test new scale for grading severity. Methods Subjects were identified by screening medical records the ICD 10 code G44.0, that is, headache. Five hundred participating research subjects filled questionnaire including personal, demographic aspects. We constructed novel cohort: Cluster Headache Severity Scale, which included number attacks per day, attack period duration....
Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated Gaucher's disease, and increased risk of Parkinson's disease (PD). We investigated the possible involvement GBA variations PD Swedish population. Three variants, E326K, N370S, L444P were screened largest Parkinson cohort reported to date; 1625 cases 2025 control individuals. found a significant with high effect size rare variant (odds ratio 8.17; 95% confidence...
Abstract Background Nearly a fifth of the world’s population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods To further elucidate these factors, we conducted genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between headache and 47 traits UK Biobank. We then tested possible causality phenotypes migraine, Mendelian randomization. In addition, attempted replication our findings in an independent...
Cluster headache is considered a male-dominated disorder, but we have previously suggested that female patients may display more severe phenotype. Studies on sex differences in cluster been conflicting; therefore, this study, with the largest validated material at present, gives insights into sex-specific characteristics of disease. The objective study was to describe patient demographics, clinical phenotype, chronobiology, triggers, treatment, and lifestyle Swedish population.Study...
Abstract The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase ( MERTK ), a cell surface receptor, was strongly associated with through genetic studies. Further, ligand galectin-3 has been found be elevated in serum patients. In this study, ligands were investigated tissue better understand their potential implication disorders. Immunohistochemistry used map...
Background: Migraine and cluster headache are two primary disorders for which conventional treatments limited. Classic psychedelic substances such as lysergic acid diethylamide (LSD) psilocybin potentially promising new treatment candidates these conditions. Aims: The aim of the present study was to investigate possible relationship between lifetime use classic psychedelics frequent bad headaches in a large British cohort sample. Methods: Using data ( N = 11,419) collected 1999–2000 part...
Cluster headache (CH) is a highly disabling primary disorder with complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims identify potential new targets for CH through proteome-wide mendelian randomization (PWMR). We used PWMR estimate the causal effects of plasma proteins on CH. analysis integrated...
Background Cluster headache is characterized by recurrent unilateral attacks of severe intensity. One the main features in a majority patients striking rhythmicity attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes transcription factor that serves as basic driving force for circadian rhythm humans and therefore particularly interesting candidate cluster headache. Methods We performed an association study on large Swedish case-control sample (449 677 controls)...
Migraine is a highly common and debilitating disorder that often affects individuals in their most productive years of life. Previous studies have identified both genetic variants brain morphometry differences associated with migraine risk. However, the relationship between has not been examined on level, causal nature association structure risk determined. Using largest available genome-wide to date, we overlap intracranial volume, as well regional volumes nine subcortical structures. We...
Cluster headache (CH) is a primary disorder which characterized by circadian timing of attacks, usually at nighttime, in around two thirds patients. Patients with CH often report sleep difficulties, though it unknown whether this cause or consequence nightly attacks.In case-control study we have assessed quality participants cluster bout respectively remission, compared to control group neurologically healthy individuals investigate the potential connection between and CH.Fifty 42 controls...
Abstract Statins are thought to have positive effects on migraine but existing data inconclusive. We aimed evaluate the causal effect of such drugs migraines using Mendelian randomization. used four types genetic instruments as proxies for HMG-CoA reductase inhibition. included expression quantitative trait loci gene and variation within or near region. Variants were associated with low-density lipoprotein cholesterol, apolipoprotein B, total cholesterol. Genome-wide association study...