A5022956629- Migraine and Headache Studies
- Thyroid Disorders and Treatments
- Trigeminal Neuralgia and Treatments
- Ophthalmology and Eye Disorders
- Psychosomatic Disorders and Their Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Functional Brain Connectivity Studies
- Body Image and Dysmorphia Studies
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Human Health and Disease
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Pain Management and Treatment
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Endometriosis Research and Treatment
- Heart Rate Variability and Autonomic Control
- Digital Innovation in Industries
- Public Relations and Crisis Communication
- Digital Marketing and Social Media
- Radiology practices and education
- Cellular transport and secretion
University Hospital Schleswig-Holstein
2014-2025
University of Lübeck
2012-2025
Clinical Research Center Kiel
2014-2025
Schmerzklinik Kiel
2012-2020
Background and purpose To screen for glucocerebrosidase ( GBA ) mutations in a Serbian Parkinson's disease (PD) population. Methods Glucocerebrosidase exons 8–11 harbouring the most common were sequenced 360 patients with PD 348 controls from Serbia. Haplotype analysis was performed N370S mutation compared German Ashkenazi Jewish carriers. Results significantly more frequent (21/360; 5.8%) vs. (5/348; 1.4%; OR = 4.25; CI, 1.58–11.40; P 0.0041). Two carried homozygous or compound heterozygous...
Background: Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to regulation of biological rhythms controlled by hypothalamus. In over 70 countries around world, time changed between daylight savings and standard twice a year due legal regulations. aim this study was investigate whether change has an influence on migraine. Methods: retrospective study, headache frequency patients with episodic or chronic at tertiary center years...
Cluster headache (CH) is a highly disabling primary disorder with complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims identify potential new targets for CH through proteome-wide mendelian randomization (PWMR). We used PWMR estimate the causal effects of plasma proteins on CH. analysis integrated...
Writing exam questions can be a valuable learning tool. We asked students to construct multiple choice for curricular exams in Internal Medicine. The the particular were chosen from pool of at least 300 student-written questions. uncorrected was accessible all students. studied influence this approach on students' habits and their test results. hypothesized that creating own could encourage discuss material.All had pass 4 7 fields Three comprised 20 questions, we applied new method one these...
Hyper-as well hypothyroidism have an effect on behavior and brain function. Moreover, during development thyroid hormones influence structure.This study aimed to demonstrate of experimentally induced hyperthyroidism gray matter in healthy adult humans.High-resolution 3D T1-weighted images were acquired 29 young subjects prior as after receiving 250 µg T4 per day for 8 weeks. Voxel-based morphometry analysis was performed using Statistical Parametric Mapping (SPM8).Laboratory testing...
Aims Disturbed levels of thyroid hormones are associated with neuropsychiatric disorders, including memory impairments. The aim this study was to evaluate effects mild induced thyrotoxicosis on working and its neural correlates. Methods Twenty-nine healthy, male subjects normal state participated in the study. Functional MRI acquired during a task (n-back task) before after ingesting 250 μg L-thyroxin per day for period eight weeks. In addition, neuropsychological tests were performed....
Tension-type headache and migraine are the second third most prevalent disorders of mankind worldwide, after dental caries. The widespread implementation smartphones enables use specific software applications (apps) for digital treatment accompaniment. In this study, app (Migräne-App) iOS Android was examined in practical patients an extensive population sample.An online survey developed analysis experiences as part accompaniment usage. It contains questions concerning sociodemographic...
Hypothyroidism is associated with memory impairments. The present study aimed to evaluate the effects of partial withdrawal levothyroxine on working tasks and brain function. Fifteen subjects under long‐term substitution as a result complete hypothyroidism participated in study. Functional magnetic resonance imaging (MRI) was performed using task (n‐back task) neuropsychological tests were before 52‐54 days after induction subclinical by reducing pretest dosage 30%. Reaction time...
Hypo‐ and hyperthyroidism have effects on brain structure function, as well cognitive processes, including memory. However, little is known about the influence of thyroid hormones perfusion relationship such changes with cognition. The present study aimed to demonstrate effect short‐term experimental in healthy volunteers assess whether changes, if present, are related performance. It that an interaction exists between cerebral oxygen consumption rate it considered neural activation...
Background The headache phenotype and neurological symptoms of the German composer Richard Wagner (1813–1883), whose music dramas count towards most frequently performed operas across world, are previously undocumented. Methods Wagner’s own descriptions his in original writings letters investigated, as well complete diary records second wife, Cosima Wagner. Results There manifold indications that suffered from a severe disorder, which fulfils likely diagnostic criteria migraine without aura...
Occipital nerve stimulation (ONS) is used to treat therapy-resistant chronic migraine. Clinical use has resulted in a wide intraindividual and interindividual variation of clinical efficacy. The aim this study was analyze potential relationship between sociodemographic variables, headache parameters, perceived sensory quality, location, as well Thirty-two subjects (21.9% male, mean age 45.77 years) suffering from migraine refractory other treatment therefore treated with ONS were included...
Abstract Thyroid hormones are modulators of cognitive functions, and changes in hormone levels affect intelligence, memory, attention executive function. Single nucleotide polymorphisms (SNPs) transporter proteins MCT8, MCT10 deiodinase 2 (DIO2) influence thyroid metabolism could therefore contribute to inter-individual variance functions. This study investigates the these SNPs using an extensive neuropsychological test battery. 656 healthy participants aged 18–39 years were genotyped for...
Abstract STUDY QUESTION Is there a difference in the use of endocrine endometriosis therapy patients with and without endometrioma? SUMMARY ANSWER Patients endometriomas received significantly less treatment (present intake 42.5%) compared to other forms 52.1%). WHAT IS KNOWN ALREADY Endocrine reduces risk recurrence therefore further surgery subsequent irreversible damage ovaries which results into reduced antral follicle counts (AFC), anti-Mullerian hormone levels (AMH), early menopause....