Thomas Hansen
A5007978629- Genetic Associations and Epidemiology
- Migraine and Headache Studies
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Neuroscience of respiration and sleep
- Congenital heart defects research
- Bipolar Disorder and Treatment
- Trigeminal Neuralgia and Treatments
- Autism Spectrum Disorder Research
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Imaging and Diagnostics
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Neurological Disorders and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Genetic and phenotypic traits in livestock
- Receptor Mechanisms and Signaling
- Health disparities and outcomes
Rigshospitalet
2016-2025
Copenhagen University Hospital
2016-2025
Glostrup Hospital
2016-2025
Novo Nordisk Foundation
2019-2025
University of Copenhagen
2016-2025
Danish Multiple Sclerosis Center
2023-2025
Montfort Hospital
2025
Illumina (United States)
2007-2024
Mental Health Services
2015-2024
Lundbeck Foundation
2015-2024
The genetic factors underlying common disease arelargely unknown. Discovery of disease-causing genes willtransform our knowledge the contribution tohuman disease, lead to new screens, and underpinresearch into cures improved lifestyles. sequencing human genome has catalyzed efforts tosearch for by strategy associating sequence variants with measurable phenotypes. In particular, Human Genome Project follow-on tocharacterize variation have resulted in discovery millions single-nucleotide...
Celiac disease (CD) is most probably an immunological disease, precipitated in susceptible individuals by ingestion of wheat gliadin and related proteins from other cereals. The shows a strong human HLA association predominantly to the cis or trans encoded HLA-DQ(alpha 1*0501,beta 1*0201) (DQ2) heterodimer. T cell recognition presented this DQ heterodimer may thus be immunopathogenic importance CD. We therefore challenged small intestinal biopsies adult CD patients on gluten-free diet vitro...
SNP genotyping arrays have been useful for many applications that require a large number of molecular markers such as high-density genetic mapping, genome-wide association studies (GWAS), and genomic selection. We report the establishment maize array its use diversity analysis high density linkage mapping. The markers, taken from more than 800,000 SNPs, were selected to be preferentially located in genes evenly distributed across genome. was tested with set germplasm including North American...
Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families schizophrenia. We examined NRXN1, closely related NRXN2 NRXN3 genes, for copy number variants (CNVs) 2977 schizophrenia patients 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy UK) using microarray data. found 66 deletions 5 duplications including a de novo deletion: 12 2 occurred cases (0.47%) compared to 49 3...
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, particular a large number loci derived from recent genome wide association studies (GWAS). True complex disease-associated often exert modest effects, so their delineation currently requires integration diverse phenotypic data to ensure robust meta-analyses. We have designed gene-centric 50 K single nucleotide polymorphism (SNP) array assess potentially relevant...
We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific distances, along confidence intervals, been estimated for all intervals. In addition, regression-based smoothed is provided facilitates interpolation of unmapped on this map. With nearly twice as many our first-generation...
Detailed knowledge of how diversity in the sequence human genome affects phenotypic depends on a comprehensive and reliable characterization both sequences variation. Over past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome large cohorts with rich data1,2. Here we describe analysis 150,119 individuals UK Biobank3. This constitutes set high-quality variants, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% all...
Electronic patient records remain a rather unexplored, but potentially rich data source for discovering correlations between diseases. We describe general approach gathering phenotypic descriptions of patients from medical in systematic and non-cohort dependent manner. By extracting phenotype information the free-text such we demonstrate that can extend contained structured record data, use it producing fine-grained stratification disease co-occurrence statistics. The uses dictionary based...
Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples. One limitation genotyping with rare variants (e.g., minor allele frequency [MAF] <0.01) is the difficulty that automated clustering algorithms have to accurately detect and assign genotype calls. Combining intensity data from samples may increase ability call genotypes variants. Approximately 62,000 ethnically diverse eleven Cohorts for Heart Aging Research...
Abstract The Great Ordovician Biodiversification Event (GOBE) was the most rapid and sustained increase in marine Phanerozoic biodiversity. What generated this biotic response across Palaeozoic seascapes is a matter of debate; several intrinsic extrinsic drivers have been suggested. One climate, which recent years has undergone paradigm shift from text-book example an extended greenhouse to interval with transient cooling intervals – at least during Late Ordovician. Here, we show first...
Background/Hypothesis Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim further explore the aura-inducing potential of levcromakalim. Methods a double-blind, randomized, placebo-controlled cross-over 27 adult participants aura received intravenous infusions levcromakalim saline. Headache, associated symptoms were evaluated for 24...
Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with identification of regulatory microRNAs (miRNAs) as important brain development and function, miRNAs emerged candidates schizophrenia-associated genetic factors. Indeed, growing understanding properties pleiotropic effects that miRNA on molecular cellular mechanisms, suggests alterations interactions between their mRNA may contribute to phenotypic variation.We studied association...