A5015767853- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Multiple and Secondary Primary Cancers
- Sympathectomy and Hyperhidrosis Treatments
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Language, Metaphor, and Cognition
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Neuroscience of respiration and sleep
- Language, Discourse, Communication Strategies
- Cardiovascular Syncope and Autonomic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Chemotherapy-related skin toxicity
- Neurological Disorders and Treatments
- Hemispheric Asymmetry in Neuroscience
- Pharmaceutical studies and practices
- Biochemical effects in animals
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuropeptides and Animal Physiology
- Psychosomatic Disorders and Their Treatments
- Advanced Neuroimaging Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Visual perception and processing mechanisms
University of Copenhagen
2016-2025
Gentofte Hospital
2023-2025
Rigshospitalet
2015-2024
Copenhagen University Hospital
2014-2024
Herlev Hospital
2024
Glostrup Hospital
2014-2023
University of Southern Denmark
2005-2022
NIHR Wellcome Trust Southampton Clinical Research Facility
2021
King's College Hospital
2021
Gyeongsang National University
2021
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide are structurally functionally closely related but show differences in migraine-inducing properties. Mechanisms responsible for the difference migraine induction unknown. Here, first time, we present a head-to-head comparison study of immediate long-lasting observations migraine-inducing, arterial, physiological biochemical responses comparing PACAP38 polypeptide. In double-blind crossover 24...
Background/Hypothesis Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim further explore the aura-inducing potential of levcromakalim. Methods a double-blind, randomized, placebo-controlled cross-over 27 adult participants aura received intravenous infusions levcromakalim saline. Headache, associated symptoms were evaluated for 24...
Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on middle meningeal artery (MMA) cerebral (MCA) using high resolution magnetic resonance angiography (MRA). Methods: In double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) 10 pmol/kg/min PACAP38 or placebo. addition, four participants following...
It is well-known that migraine attacks can be precipitated by various stimuli. More than 50% of patients with aura (MA) know at least one stimulus always or often triggers their MA attacks. The objective this study was to expose self-reported trigger factors in order assess the causal relation between and attacks.We recruited 27 who reported bright flickering light strenuous exercise would were experimentally provoked different types photo stimulation, exercise, a combination these 2...
See Schoenen (doi: 10.1093/awv402 ) for a scientific commentary on this article. Migraine with aura is prevalent in high-altitude populations suggesting an association between migraine and hypoxia. We investigated whether experimental hypoxia triggers attacks patients suffering from aura. also the metabolic vascular response to In randomized double-blind crossover study design, 15 were exposed 180 min of normobaric (capillary oxygen saturation 70–75%) or sham two separate days 14 healthy...
See Moskowitz (doi:10.1093/brain/awx099) for a scientific commentary on this article.The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed headache. It currently not understood how the related to headache phase of migraine. Animal studies suggest spreading depression, likely mechanism aura, causes disruption blood-brain barrier and noxious stimulation trigeminal afferents leading activation brainstem...
Background Functional connectivity of brain networks may be altered in migraine without aura patients. magnetic resonance imaging (fMRI) studies have demonstrated changed activity the thalamus, pons and cerebellum migraineurs. Here, we investigated thalamic, pontine cerebellar network during spontaneous attacks. Methods Seventeen patients with episodic underwent resting-state fMRI scan outside a attack. Primary endpoint was difference functional between attack headache-free days. assessed...
Abstract Migraine afflicts more than one billion individuals worldwide and is a leading cause of years lived with disability. In about third migraine aura occur in relation to headache. The common pathophysiological mechanisms underlying headache are yet be identified. Based on recent data, we hypothesized that levcromakalim, an ATP-sensitive potassium channel opener, would trigger attacks patients. randomized, double-blind, placebo-controlled, crossover study, 17 patients aged 21–59...
Triptans are contraindicated in patients with ischemic heart disease or previous myocardial infarction, and caution is advised when prescribing these drugs to vascular risk factors. However, controlled observational studies have either shown no association an apparent lower risk, possibly owing a channeling of triptans individuals at low cardiovascular outcomes, it remains unclear whether avoiding triptan treatment for meaningful.
Introduction Migraine is a complex neurological disorder that affects significant portion of the global population. As traditional pharmacological approaches often fall short in alleviating symptoms, development innovative therapies has garnered interest. This text aims to summarize current options for managing migraine and explore potential impact novel therapies.
Migraine is a multifaceted primary headache disorder. In neuroimaging of migraine, fMRI has been used to elucidate pathophysiology or monitor treatment effects. The current literature, however, highly heterogeneous regarding reported variables and methodologies. This begets lack comparability complicates synthesis results across studies. We developed framework for standardized reporting studies in migraine. Experts on migraine were identified from the literature subjected structured...
To investigate resting-state functional connectivity in the salience network (SN), sensorimotor (SMN), and default mode (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38).In a double-blind, randomized study, 24 female patients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related cause vasodilation, but only induces attacks. VIP was therefore used as active placebo....
AbstractBackground: Patients admitted with aphasia due to stroke may find it difficult access information and participate in decision-making concerning their own treatment, care, rehabilitation. An increased understanding of the importance communicative has prompted speech-language therapists direct intervention at contextual factors, including communication partner training.Aims: implementation project is described which supported conversation for adults (SCA™) was adapted use a large...
To detect and localise the Christmas spirit in human brain.Single blinded, cross cultural group study with functional magnetic resonance imaging (fMRI).Functional unit department of clinical physiology, nuclear medicine PET Denmark.10 healthy people from Copenhagen area who routinely celebrate 10 living same have no traditions.Brain activation unique to traditions during visual stimulation images a theme.Functional brain scans optimised for detection blood oxygen level dependent (BOLD)...
The integrity of the blood-brain barrier (BBB) has been questioned in migraine, but BBB permeability never investigated during spontaneous migraine attacks. In present study, attacks without aura was compared to an interictal state.Seventy-four patients suffering from were recruited participate this cross-sectional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) study. instructed report at hospital for DCE-MRI scan and outside a attack. primary end-point difference (ml/100...
Abstract The neurological disturbances of migraine aura are caused by transient cortical dysfunction due to waves spreading depolarization that disrupt neuronal signaling. effects these events on intrinsic brain connectivity during attacks have not previously been investigated. Studies spontaneous notoriously challenging their unpredictable nature and patient discomfort. We investigated 16 patients with visual in the attack‐free state using resting fMRI. applied a hypothesis‐driven...