Nick Patterson
A5091212930- Forensic and Genetic Research
- Genetic Associations and Epidemiology
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Archaeology and ancient environmental studies
- Genomics and Phylogenetic Studies
- Race, Genetics, and Society
- Pleistocene-Era Hominins and Archaeology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- RNA and protein synthesis mechanisms
- Evolution and Genetic Dynamics
- Epigenetics and DNA Methylation
- Yersinia bacterium, plague, ectoparasites research
- Genomic variations and chromosomal abnormalities
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Finite Group Theory Research
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- Environmental DNA in Biodiversity Studies
- Pacific and Southeast Asian Studies
- Multiple Sclerosis Research Studies
- BRCA gene mutations in cancer
- graph theory and CDMA systems
Broad Institute
2014-2023
Harvard University
2004-2023
Evolutionary Genomics (United States)
2022
Massachusetts Institute of Technology
2006-2018
Institute for Advanced Study
2017
Boston University
2012
Howard Hughes Medical Institute
2004
Multiple Sclerosis Center of Atlanta
2004
University of California, San Francisco
2004
Whitehead Institute for Biomedical Research
2003
Current methods for inferring population structure from genetic data do not provide formal significance tests differentiation. We discuss an approach to studying (principal components analysis) that was first applied by Cavalli-Sforza and colleagues. place the method on a solid statistical footing, using results modern statistics develop tests. also uncover general "phase change" phenomenon about ability detect in data, which emerges theory we use, has important implication discover data:...
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence Neandertal genome composed more than 4 billion nucleotides from three individuals. Comparisons to genomes five humans different world identify number genomic regions that may have been affected by positive selection ancestral modern including genes involved metabolism cognitive skeletal development. show...
Using DNA extracted from a finger bone found in Denisova Cave southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is group that shares common origin with Neanderthals. population was not involved putative gene flow Neanderthals into Eurasians; however, data suggest it contributed 4–6% its genetic material genomes present-day Melanesians. We designate this 'Denisovans' and may been widespread Asia during Late Pleistocene epoch. A...
One enduring question in evolutionary biology is the extent of archaic admixture genomes present-day populations. In this paper, we present a test for ancient that exploits asymmetry frequencies two nonconcordant gene trees three-population tree. This was first applied to detect interbreeding between Neandertals and modern humans. We derive analytic expectation statistic, called D which sensitive under alternative demographic scenarios. show statistic insensitive some assumptions such as...
Identifying the ancestry of chromosomal segments distinct has a wide range applications from disease mapping to learning about history. Most methods require use unlinked markers; but, using all markers genome-wide scanning arrays, it should in principle be possible infer even very small with exquisite accuracy. We describe method, HAPMIX, which employs an explicit population genetic model perform such local inference based on fine-scale variation data. show that HAPMIX outperforms other...
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, particular a large number loci derived from recent genome wide association studies (GWAS). True complex disease-associated often exert modest effects, so their delineation currently requires integration diverse phenotypic data to ensure robust meta-analyses. We have designed gene-centric 50 K single nucleotide polymorphism (SNP) array assess potentially relevant...
Significance The hunter–gatherer and pastoralist populations of southern Africa are among the culturally, linguistically, genetically most diverse human populations. However, little is known about their history. We show that all these have some ancestry closely related to Europeans Middle Easterners use this reconstruct history population movements between Eurasia, eastern Africa, Africa.
Abstract qpAdm is a statistical tool for studying the ancestry of populations with histories that involve admixture between two or more source populations. Using qpAdm, it possible to identify plausible models fit population history group interest and calculate relative proportion can be ascribed each in model. Although widely used studies human (and nonhuman) groups, relatively little has been done assess its performance. We performed simulation study behavior under various scenarios order...
More than two hundred papers have reported genome-wide data from ancient humans. While the raw for vast majority are fully publicly available testifying to commitment of paleogenomics community open data, formats both and meta-data differ. There is thus a need uniform curation centralized, version-controlled compendium that researchers can download, analyze, reference. Since 2019, we been maintaining Allen Ancient DNA Resource (AADR), which aims provide an up-to-date, curated version world’s...
Abstract The history of the British Isles and Ireland is characterized by multiple periods major cultural change, including influential transformation after end Roman rule, which precipitated shifts in language, settlement patterns material culture 1 . extent to migration from continental Europe mediated these transitions a matter long-standing debate 2–4 Here we study genome-wide ancient DNA 460 medieval northwestern Europeans—including 278 individuals England—alongside archaeological data,...