Michael Lachmann
A5019027915- Evolutionary Game Theory and Cooperation
- Evolution and Genetic Dynamics
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Behavior and Reproduction
- Plant and animal studies
- Forensic and Genetic Research
- Pleistocene-Era Hominins and Archaeology
- Experimental Behavioral Economics Studies
- Data-Driven Disease Surveillance
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Origins and Evolution of Life
- Mathematical and Theoretical Epidemiology and Ecology Models
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Chromatin Dynamics
- Game Theory and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Primate Behavior and Ecology
- Language and cultural evolution
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- COVID-19 Clinical Research Studies
Santa Fe Institute
2002-2024
University of Georgia
2024
The University of Texas at Austin
2021-2023
Northwestern University
2023
Columbia University
2021
Brandeis University
2018
Max Planck Institute for Evolutionary Anthropology
2006-2016
Google (United States)
2016
Max Planck Society
2005-2013
Helios Kliniken
2013
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence Neandertal genome composed more than 4 billion nucleotides from three individuals. Comparisons to genomes five humans different world identify number genomic regions that may have been affected by positive selection ancestral modern including genes involved metabolism cognitive skeletal development. show...
High-coverage sequencing of 79 (wild and captive) individuals representing all six non-human great ape species has identified over 88 million single nucleotide polymorphisms providing insight into genetic variation evolutionary history enabling comparison with human diversity. In an effort to provide insights variation, the authors sequence wild- captive-born from across seven subspecies. Their data analyses shed light on population structure gene flow, inbreeding, inferred dynamics...
Many waterbodies across the United States do not meet water quality standards. To help determine where and to what extent improvements should be sought, policymakers must consider costs of regulations with their monetized values. We ...Scientific knowledge related quantifying benefits for landscape-wide does current regulatory benefit–cost analysis needs in States. In this study we addressed gap by ...
The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects evolution human genome. Here we compare humans chimpanzees with respect differences in expression levels protein-coding sequences for genes active brain, heart, liver, kidney, testis. We find that patterns gene are markedly similar. In particular, there is gradation selective constraints among tissues so brain shows least between species whereas liver most. Furthermore, as...
Sequencing of the bonobo genome shows that more than three per cent human is closely related to either or chimpanzee those genomes are each other. The and our species' two closest living relatives. This paper reports sequence bonobo, last ape be sequenced. Comparative genomic analyses reveal 3% these results shed light on ancestry species might eventually help us understand genetic basis phenotypes humans share with one other species. Two African apes relatives humans: (Pan troglodytes)...
In development, timing is of the utmost importance, and developmental processes often changes as organisms evolve. human evolution, retardation, or neoteny, has been proposed a possible mechanism that contributed to rise many human-specific features, including an increase in brain size emergence cognitive traits. We analyzed mRNA expression prefrontal cortex humans, chimpanzees, rhesus macaques determine whether neotenic are present at gene level. show transcriptome dramatically remodeled...
Changes in gene expression levels determine differentiation of tissues involved development and are associated with functional decline aging. Although is tightly regulated, the transition between aging, as well regulation post-developmental changes, not understood. Here, we measured messenger RNA (mRNA), microRNA (miRNA), protein prefrontal cortex humans rhesus macaques over species' life spans. We find that few changes unique to Instead, vast majority miRNA occur aging represent reversals...
It is now possible to perform whole-genome shotgun sequencing as well capture of specific genomic regions for extinct organisms. However, targeted resequencing large parts nuclear genomes has yet be demonstrated ancient DNA. Here we show that hybridization on microarrays can successfully recover more than a megabase target from Neandertal DNA even in the presence ~99.8% microbial Using this approach, have sequenced ~14,000 protein-coding positions inferred changed human lineage since last...
Short-term probabilistic forecasts of the trajectory COVID-19 pandemic in United States have served as a visible and important communication channel between scientific modeling community both general public decision-makers. Forecasting models provide specific, quantitative, evaluable predictions that inform short-term decisions such healthcare staffing needs, school closures, allocation medical supplies. Starting April 2020, US Forecast Hub ( https://covid19forecasthub.org/ ) collected,...
SummaryBackgroundTo mitigate the COVID-19 pandemic, countries worldwide have enacted unprecedented movement restrictions, physical distancing measures, and face mask requirements. Until safe efficacious vaccines or antiviral drugs become widely available, viral testing remains primary mitigation measure for rapid identification isolation of infected individuals. We aimed to assess economic trade-offs expanding accelerating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across...
Scientists have grappled with reconciling biological evolution1,2 the immutable laws of Universe defined by physics. These underpin life's origin, evolution and development human culture technology, yet they do not predict emergence these phenomena. Evolutionary theory explains why some things exist others through lens selection. To comprehend how diverse, open-ended forms can emerge from physics without an inherent design blueprint, a new approach to understanding quantifying selection is...
Abstract Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, United States Centers for Disease Control Prevention (CDC) partnered with academic research lab University of Massachusetts Amherst to create US Forecast Hub. Launched in April 2020, Hub is a dataset point probabilistic incident cases, hospitalizations, deaths, cumulative deaths due county, state,...
Microarray technologies allow the identification of large numbers expression differences within and between species. Although environmental physiological stimuli are clearly responsible for changes in levels many genes, it is not known whether majority gene fixed during evolution species various tissues a caused by Darwinian selection or stochastic processes. We find following: (1) accumulate approximately linearly with time; (2) variation among individuals correlates positively divergence...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human chimpanzee individuals, the transcriptomes cerebral cortex are very similar to each other differ more between individuals than among within an individual. In contrast, cortex, caudate nucleus, cerebellum substantially from other. Between chimpanzees, 10% genes their at least one region brain. The majority these differences shared all regions. Whereas encoding proteins involved signal...
The “costly signaling” hypothesis proposes that animal signals are kept honest by appropriate signal costs. We show to the contrary, cost is unnecessary for signaling even when interests conflict. illustrate this principle constructing examples of cost-free equilibria two paradigmatic games Grafen (1990) and Godfray (1991). Our findings may explain why some use ensure honesty whereas others do not suggest empirical tests should focus on equilibrium but, rather, deviation from equilibrium....
We discuss simple models for the evolution of rates spontaneous and induced heritable phenotypic variations in a periodically fluctuating environment with cycle length between two 100 generations. For simplest case, optimal transition rate states is approximately 1/n(wherenis length). It also shown that selection under these conditions surprisingly strong. Whennis small, this means are produced by non-classical inheritance systems, including non-DNA systems. Thus, it predicted genes...
Communication and information are central concepts in evolutionary biology. In fact, it is hard to find an area of biology where these not used. However, quantifying the transferred biological interactions has been difficult. How much when first spring rainfall hits a dormant seed, or chick begs for food from its parent? One measure that commonly used such cases fitness value: by how much, on average, individual's would increase if behaved optimally with new information, compared average...
Abstract Summary: We present a tool suited for searching many short nucleotide sequences in large databases, allowing predefined number of gaps and mismatches. The commandline-driven program implements non-deterministic automata matching algorithm on keyword tree the search strings. Both queries with without ambiguity codes can be searched. Search time is perfect matches, retrieval rises exponentially edits allowed. Availability: C++ source code PatMaN distributed under GNU General Public...
Genome-wide expression, sequence and association studies typically yield large sets of gene candidates, which must then be further analysed interpreted. Information about these genes is increasingly being captured organized in ontologies, such as the Gene Ontology. Relationships between identified by experimental methods biological knowledge can made explicit used interpretation results. However, it often difficult to assess statistical significance analyses since many inter-dependent...
Abstract We propose a Bayesian model for projecting first-wave COVID-19 deaths in all 50 U.S. states. Our model’s projections are based on data derived from mobile-phone GPS traces, which allows us to estimate how social-distancing behavior is “flattening the curve” each state. In two-week look-ahead test of out-of-sample forecasting accuracy, our significantly outperforms widely used Institute Health Metrics and Evaluation (IHME), achieving 42% lower prediction error: 13.2 per day average...