Tiago Carvalho
A5090038370- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Cell Image Analysis Techniques
- Nutritional Studies and Diet
- Neurogenesis and neuroplasticity mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Digestive system and related health
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nutrition, Genetics, and Disease
- Evolution and Genetic Dynamics
- Consumer Attitudes and Food Labeling
- Primate Behavior and Ecology
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Biochemical Analysis and Sensing Techniques
University of Trás-os-Montes and Alto Douro
2024
Universitat Pompeu Fabra
2013-2018
Institut de Biologia Evolutiva
2013-2018
Barcelona Biomedical Research Park
2017
Consejo Superior de Investigaciones Científicas
2017
High-coverage sequencing of 79 (wild and captive) individuals representing all six non-human great ape species has identified over 88 million single nucleotide polymorphisms providing insight into genetic variation evolutionary history enabling comparison with human diversity. In an effort to provide insights variation, the authors sequence wild- captive-born from across seven subspecies. Their data analyses shed light on population structure gene flow, inbreeding, inferred dynamics...
The makings of the primate brain Although nonhuman brains are similar to our own, disparity between their and cognitive abilities tells us that surface similarity is not whole story. Sousa et al. overlaid transcriptome histological analyses see what makes human different from those primates. Various differentially expressed genes, such as encoding transcription factors, could alter transcriptional programs. Others were associated with neuromodulatory systems. Furthermore, dopaminergic...
Significance The X chromosome has a different inheritance pattern from the autosomes, direct interaction and potential conflict with Y chromosome, fewer copies than autosomes. Natural selection may, therefore, act differently on chromosome. We analyze polymorphism patterns in 10 great ape species using 87 high-coverage whole genomes. find that contains megabase-sized regions are almost without variation most species. No such found suggest independent very strong selective sweeps only...
Tandem repeats (TRs) are stretches of DNA that highly variable in length and mutate rapidly. They thus an important source genetic variation. This variation is informative for population conservation genetics. It has also been associated with several pathological conditions gene expression regulation. However, genome-wide surveys TR humans closely related species have scarce due to technical difficulties derived from short-read technology. Here we explored the diversity TRs a panel 83 human...
Tandem repeats (TR) are stretches of DNA that highly variable in length and mutate rapidly, thus an important source genetic variation. This variation is informative for population conservation genetics, has also been associated with several pathological conditions gene expression regulation. However, genome-wide surveys TR have scarce due to the technical difficulties derived from short-read technology. Here, we explored diversity TRs a panel 83 human nonhuman great ape genomes, their...
Research in evolutionary biology has been progressively influenced by big data such as massive genome and transcriptome sequencing data, scalar measurements of several phenotypes on tens to thousands individuals, well from collecting worldwide environmental at an increasingly detailed scale. The handling analysis require computational skills that usually exceed the abilities most traditionally trained biologists. Here we discuss advantages, challenges considerations for organizing running...